Natural lysophospholipids reduce Mycobacterium tuberculosis-induced cytotoxicity and induce anti-mycobacterial activity by a phagolysosome maturation-dependent mechanism in A549 type II alveolar epithelial cells

Immunology

Volumn 129, Issue 1, 2010, Pages 125-132

  Greco, Emanuela ^a   Santucci, Marilina B ^a   Sali, Michela ^b   De Angelis, Francesca R ^a   Papi, Massimiliano ^b   De Spirito, Marco ^b   Delogu, Giovanni ^b   Colizzi, Vittorio ^a   Fraziano, Maurizio ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

Author keywords

Alveolar epithelial cells; Dissemination; Lysophospholipid; Primary infection; Tuberculosis

Indexed keywords

CALCIUM ION; LYSOPHOSPHATIDIC ACID; LYSOPHOSPHOLIPID; PHOSPHOLIPASE D; SPHINGOSINE 1 PHOSPHATE;

ARTICLE; BACTERIAL TRANSLOCATION; BACTERICIDAL ACTIVITY; CELL MATURATION; CELL PROTECTION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; HOST PATHOGEN INTERACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR KILLING; LUNG ALVEOLUS EPITHELIUM; MACROPHAGE; MICROBIAL ACTIVITY; MICROENVIRONMENT; MOLECULAR MECHANICS; MOLECULAR MODEL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHAGOLYSOSOME; PRIORITY JOURNAL;

APOPTOSIS; CELL LINE; CYTOPROTECTION; DISEASE TRANSMISSION, INFECTIOUS; EPITHELIAL CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; LYSOPHOSPHOLIPIDS; MACROPHAGES, ALVEOLAR; MYCOBACTERIUM TUBERCULOSIS; PHAGOSOMES; PHOSPHOLIPASE D; PULMONARY ALVEOLI; SPHINGOSINE; TUBERCULOSIS;

EID: 71649089075     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2009.03145.x     Document Type: Article

References (29)

1. World Health Organization. Fact Sheet No. 104. Geneva: World Health Organization, 2006.
2. Flynn JL. Immunology of tuberculosis and implications in vaccine development. Tuberculosis (Edinb) 2004 84: 93 101.
3. Bermudez LE, Goodman J. Mycobacterium tuberculosis invades and replicates within type II alveolar cells. Infect Immun 1996 64: 1400 1406.
4. Kaufmann SH. How can Immunology contribute to the control of tuberculosis? Nat Rev Immunol 2001 1: 20 30.
5. Hernández-Pando R, Jeyanathan M, Mengistu G, Aguilar D, Orozco H, Harboe M, Rook GA, Bjune G. Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection. Lancet 2000 356: 2133 2138.
6. Ellner J, Hirsch C, Whalen C. Correlates of protective immunity to Mycobacterium tuberculosis in humans. Clin Infect Dis 2000 30: S279 82.
7. van Crevel R, Ottenhof T, van der Meer J. Innate immunity to Mycobacterium tuberculosis. Adv Exp Med Biol 2003 531: 294 309.
8. Bals R, Hiemstra PS. Innate immunity in the lung: how epithelial cells fight against respiratory pathogens. Eur Respir J 2004 23: 327 333.
9. Zhang P, Summer WR, Bagby GJ, Nelson S. Innate immunity and pulmonary host defense. Immunol Rev 2000 173: 39 51.
10. Anes E, Kuhnel MP, Bos E, Moniz-Pereira J, Habermann A, Griffiths G. Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria. Nat Cell Biol 2003 5: 793 802.
11. Gutierrez MG, Gonzalez AP, Anes E, Griffiths G. Role of lipids in killing mycobacteria by macrophages: evidence for NF-kB-dependent and-independent killing induced by different lipids. Cell Microbiol 2009 11: 406 420.
12. Ishii I, Fukushima N, Ye X, Chun J. Lysophospholipid receptors: signalling and biology. Annu Rev Biochem 2004 73: 321 354.
13. Garg SK, Volpe E, Palmieri G et al. Sphingosine 1-phosphate induces antimicrobial activity both in vitro and in vivo. J Infect Dis 2004 189: 2129 2138.
14. Garg SK, Valente E, Greco E et al. Lysophosphatidic acid enhances antimycobacterial activity both in vitro and ex vivo. Clin Immunol 2006 121: 23 8.
15. 2+-dependent Phospholipase D leading to phagolysosome maturation and mycobacteriocidal activity in monocytes. Biochem Biophys Res Commun 2006 347: 963 969.
16. Danelishvili L, McGarvey J, Li YJ, Bermudez LE. Mycobacterium tuberculosis infection causes different levels of apoptosis and necrosis in human macrophages and alveolar epithelial cells. Cell Microbiol 2003 5: 649 660.
17. Russell DG. TB comes to a sticky beginning. Nat Med 2001 7: 894 895.
18. Roy S, Sharma S, Sharma M, Aggarwal R, Bose M. Induction of nitric oxide release from the human alveolar epithelial cell line A549: an in vitro correlate of innate immune response to Mycobacterium tuberculosis. Immunology 2004 112: 471 480.
19. +) signaling by Mycobacterium tuberculosis is associated with reduced phagosome-lysosome fusion and increased survival within human macrophages. J Exp Med 2000 191: 287 302.
20. Auricchio G, Garg SK, Martino A et al. Role of macrophage phospholipase D in natural and CpG-induced antimycobacterial activity. Cell Microbiol 2003 5: 913 920.
21. 7-dependent process inducing bacterial death by phagosome-lysosome fusion. J Immunol 2001 167: 3300 3307.
22. Menozzi FD, Reddy VM, Cayet D, Raze D, Debrie AS. Dehouck MP. Mycobacterium tuberculosis heparin binding haemagglutinin adhesion (HBHA) triggers receptor mediated transcytosis without altering the integrity of tight junction. Microbes Infect 2005 8: 1 9.
23. + T cells. Am J Physiol Lung Cell Mol Physiol 2005 289: 274 279.
24. Radeff-Huang J, Seasholtz TM, Matteo RG, Brown JH. G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival. J Cell Biochem 2004 92: 949 966.
25. McDonough KA, Kress Y. Cytotoxicity for lung epithelial cells is a virulence-associated phenotype of Mycobacterium tuberculosis. Infect Immun 1995 63: 4802 4811.
26. Kusner DJ, Adams J. ATP-induced killing of virulent Mycobacterium tuberculosis within human macrophages requires phospholipase D. J Immunol 2000 164: 379 388.
27. Balasubramanian V, Wiegeshaus EH, Taylor BT, Smith DW. Pathogenesis of tuberculosis: pathway to apical localization. Tuber Lung Dis 1994 75: 168 178.
28. Manabe C, Bishai WR. Latent Mycobacterium tuberculosis persistence, patience, and winning by waiting. Nat Med 2000 6: 1327 1329.
29. Mander A, Langton-Hewer S, Bernhard W, Warner JO, Postle AD. Altered phospholipid composition and aggregate structure of lung surfactant is associated with impaired lung function in young children with respiratory infections. Am J Respir Cell Mol Biol 2002 27: 714 721.