Reduced activation in the mirror neuron system during a virtual social cognition task in euthymic bipolar disorder

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 33, Issue 8, 2009, Pages 1409-1416

  Kim, Eosu ^a   Jung, Young Chul ^a   Ku, Jeonghun ^b   Kim, Jae Jin ^a   Lee, Hyeongrae ^b   Kim, So Young ^c   Kim, Sun I ^b   Cho, Hyun Sang ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Hanyang University   (South Korea)

^c Samsumg Medical Center   (South Korea)

Author keywords

Bipolar disorder; Emotional processing; Functional MRI; Mirror neuron system; Social cognition; Virtual reality

Indexed keywords

ADULT; ANGER; ARTICLE; ASSOCIATION; BIPOLAR DISORDER; CINGULATE GYRUS; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; EMOTIONALITY; EMPATHY; FACIAL EXPRESSION; FEMALE; FRONTAL CORTEX; HAPPINESS; HUMAN; MALE; MENTAL TASK; NERVE CELL STIMULATION; NONVERBAL COMMUNICATION; PREMOTOR CORTEX; RESPONSE TIME; SOCIAL BEHAVIOR; SYMPTOM; VERBAL COMMUNICATION; VIRTUAL REALITY;

ADOLESCENT; ADULT; BIPOLAR DISORDER; BRAIN MAPPING; CEREBRAL CORTEX; COGNITION; EMOTIONS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; OXYGEN; SOCIAL BEHAVIOR; USER-COMPUTER INTERFACE; YOUNG ADULT;

EID: 71549172774     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2009.07.019     Document Type: Article

References (44)

1. Adolphs R. Social cognition and the human brain. Trends Cogn Sci 3 (1999) 469-479
2. Amodio D.M., and Frith C.D. Meeting of minds: the medial frontal cortex and social cognition. Nat Rev Neurosci 7 (2006) 268-277
3. Aleman A., and Swart M. Sex differences in neural activation to facial expressions denoting contempt and disgust. PLoS ONE 3 (2008) e3622 10.1371/journal.pone.0003622
4. Annett M. A classification of hand preference by association analysis. Br J Psychol 61 (1970) 303-321
5. Blumberg H.P., Donegan N.H., Sanislow C.A., Collins S., Lacadie C., Skudlarski P., et al. Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder. Psychopharmacology (Berl) 183 (2005) 308-313
6. Bora E., Vahip S., Gonul A.S., Akdeniz F., Alkan M., Ogut M., et al. Evidence for theory of mind deficits in euthymic patients with bipolar disorder. Acta Psychiatr Scand 112 (2005) 110-116
7. Bozikas V.P., Tonia T., Fokas K., Karavatos A., and Kosmidis M.H. Impaired emotion processing in remitted patients with bipolar disorder. J Affect Disord 91 (2006) 53-56
8. Carr L., Iacoboni M., Dubeau M.C., Mazziotta J.C., and Lenzi G.L. Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas. Proc Natl Acad Sci U S A 100 (2003) 5497-5502
9. Cox R.W. AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 29 (1996) 162-173
10. Curtis V.A., Thompson J.M., Seal M.L., Monks P.J., Lloyd A.J., Harrison L., et al. The nature of abnormal language processing in euthymic bipolar I disorder: evidence for a relationship between task demand and prefrontal function. Bipolar Disord 9 (2007) 358-369
11. Danziger N., Faillenot I., and Peyron R. Can we share a pain we never felt? Neural correlates of empathy in patients with congenital insensitivity to pain. Neuron 61 (2009) 203-212
12. Dickerson F.B., Sommerville J., Origoni A.E., Ringel N.B., and Parente F. Outpatients with schizophrenia and bipolar I disorder: do they differ in their cognitive and social functioning?. Psychiatry Res 102 (2001) 21-27
13. Dolcos F., and McCarthy G. Brain systems mediating cognitive interference by emotional distraction. J Neurosci 26 (2006) 2072-2079
14. Foland L.C., Altshuler L.L., Bookheimer S.Y., Eisenberger N., Townsend J., and Thompson P.M. Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania. Psychiatry Res 162 (2008) 27-37
15. Gallese V. Before and below 'theory of mind': embodied simulation and the neural correlates of social cognition. Philos Trans R Soc Lond B Biol Sci 362 (2007) 659-669
16. Green M.J., Cahill C.M., and Malhi G.S. The cognitive and neurophysiological basis of emotion dysregulation in bipolar disorder. J Affect Disord 103 (2007) 29-42
17. Gruber S.A., Rogowska J., and Yurgelun-Todd D.A. Decreased activation of the anterior cingulate in bipolar patients: an fMRI study. J Affect Disord 82 (2004) 191-201
18. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 23 (1960) 56-62
19. Harmer C.J., Grayson L., and Goodwin G.M. Enhanced recognition of disgust in bipolar illness. Biol Psychiatry 51 (2002) 298-304
20. Jabbi M., Swart M., and Keysers C. Empathy for positive and negative emotions in the gustatory cortex. Neuroimage 34 (2007) 1744-1753
21. Jonides J., Smith E.E., Marshuetz C., Koeppe R.A., and Reuter-Lorenz P.A. Inhibition in verbal working memory revealed by brain activation. Proc Natl Acad Sci U S A 95 (1998) 8410-8413
22. Kerr N., Dunbar R.I., and Bentall R.P. Theory of mind deficits in bipolar affective disorder. J Affect Disord 73 (2003) 253-259
23. Kim E., Ku J., Kim J.J., Lee H., Han K., Kim S.I., et al. Nonverbal social behaviors of patients with bipolar mania during interactions with virtual humans. J Nerv Ment Dis 197 (2009) 412-418
24. Ku J., Jang H.J., Kim K.U., Kim J.H., Park S.H., Lee J.H., et al. Experimental results of affective valence and arousal to avatar's facial expressions. Cyberpsychol Behav 8 (2005) 493-503
25. Lembke A., and Ketter T.A. Impaired recognition of facial emotion in mania. Am J Psychiatry 159 (2002) 302-304
26. Loomis J.M., Blascovich J.J., and Beall A.C. Immersive virtual environment technology as a basic research tool in psychology. Behav Res Meth Instrum Comput 31 (1999) 557-564
27. Malhi G.S., Lagopoulos J., Sachdev P.S., Ivanovski B., and Shnier R. An emotional Stroop functional MRI study of euthymic bipolar disorder. Bipolar Disord 7 Suppl 5 (2005) 58-69
28. Malhi G.S., Lagopoulos J., Owen A.M., Ivanovski B., Shnier R., and Sachdev P. Reduced activation to implicit affect induction in euthymic bipolar patients: an fMRI study. J Affect Disord 97 (2007) 109-122
29. Mason R.A., and Just M.A. Lexical ambiguity in sentence comprehension. Brain Res 1146 (2007) 115-127
30. Olley A.L., Malhi G.S., Bachelor J., Cahill C.M., Mitchell P.B., and Berk M. Executive functioning and theory of mind in euthymic bipolar disorder. Bipolar Disord 7 Suppl 5 (2005) 43-52
31. Olsson A., and Ochsner K.N. The role of social cognition in emotion. Trends Cogn Sci 12 (2008) 65-71
32. Park K.M., Kim J.J., Ku J., Kim S.Y., Lee H.R., Kim S.I., et al. Neural basis of attributional style in schizophrenia. Neurosci Lett 459 (2009) 35-40
33. Pavuluri M.N., O'Connor M.M., Harral E., and Sweeney J.A. Affective neural circuitry during facial emotion processing in pediatric bipolar disorder. Biol Psychiatry 62 (2007) 158-167
34. Phillips M.L., Travis M.J., Fagiolini A., and Kupfer D.J. Medication effects in neuroimaging studies of bipolar disorder. Am J Psychiatry 165 (2008) 313-320
35. Sanchez-Vives M.V., and Slater M. From presence to consciousness through virtual reality. Nat Rev Neurosci 6 (2005) 332-339
36. Saxe R. Why and how to study Theory of Mind with fMRI. Brain Res 1079 (2006) 57-65
37. Shamay-Tsoory S.G., Aharon-Peretz J., and Perry D. Two systems for empathy: a double dissociation between emotional and cognitive empathy in inferior frontal gyrus versus ventromedial prefrontal lesions. Brain 3 (2009) 617-627
38. Shamay-Tsoory S., Harari H., Szepsenwol O., and Levkovitz Y. Neuropsychological evidence of impaired cognitive empathy in euthymic bipolar disorder. J Neuropsychiatry Clin Neurosci 21 (2009) 59-67
39. Singer T., Seymour B., O'Doherty J., Kaube H., Dolan R.J., and Frith C.D. Empathy for pain involves the affective but not sensory components of pain. Science 303 (2004) 1157-1162
40. Strakowski S.M., Adler C.M., Holland S.K., Mills N., and DelBello M.P. A preliminary FMRI study of sustained attention in euthymic, unmedicated bipolar disorder. Neuropsychopharmacology 29 (2004) 1734-1740
41. Wessa M., Houenou J., Paillere-Martinot M.L., Berthoz S., Artiges E., Leboyer M., et al. Fronto-striatal overactivation in euthymic bipolar patients during an emotional go/nogo task. Am J Psychiatry 164 (2007) 638-646
42. Witmer B.G., and Singer M.J. Measuring presence in virtual environments: a presence questionnaire. Presence-Teleoper Virtual Environ 1998 (1998) 225-240
43. Young R.C., Biggs J.T., Ziegler V.E., and Meyer D.A. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 133 (1978) 429-435
44. Yurgelun-Todd D.A., Gruber S.A., Kanayama G., Killgore W.D., Baird A.A., and Young A.D. fMRI during affect discrimination in bipolar affective disorder. Bipolar Disord 2 (2000) 237-248