Steady-state pharmacokinetics and tolerability of orally administered fampridine sustained-Release 10-mg tablets in patients with multiple sclerosis: A 2-week, open-label, follow-up study

Clinical Therapeutics

Volumn 31, Issue 10, 2009, Pages 2215-2223

  Vollmer, Timothy ^a   Blight, Andrew R ^b   Henney III, Herbert R ^b  

^a UNIVERSITY OF COLORADO   (United States)

^b ACORDA THERAPEUTICS INC   (United States)

Author keywords

4 aminopyridine; fampridine SR; immediate release fampridine; multiple sclerosis; pharmacokinetics; sustained release

Indexed keywords

4 AMINOPYRIDINE;

ADULT; AGE DISTRIBUTION; AMNESIA; ANOREXIA; AREA UNDER THE CURVE; ARTHRALGIA; ARTICLE; ASTHENIA; ATAXIA; BODY WEIGHT; CAUCASIAN; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DOSE ESCALATION; DRUG DOSE TITRATION; DRUG HALF LIFE; DRUG INDUCED HEADACHE; DRUG TOLERABILITY; ECG ABNORMALITY; EDEMA; EVENING DOSAGE; FEMALE; FOLLOW UP; GAIT; HEART PALPITATION; HUMAN; INFECTION; INJECTION SITE PAIN; INSOMNIA; LABORATORY TEST; MALE; MAXIMUM PLASMA CONCENTRATION; METABOLIC DISORDER; MORNING DOSAGE; MOUTH ULCER; MULTICENTER STUDY; MULTIPLE DRUG DOSE; MULTIPLE SCLEROSIS; MUSCLE HYPERTONIA; NAUSEA; NERVOUSNESS; NUTRITIONAL DISORDER; OPEN STUDY; PAIN; PARESTHESIA; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PHYSICAL EXAMINATION; QRS COMPLEX; QT INTERVAL; QT PROLONGATION; SEX RATIO; SIDE EFFECT; SINGLE DRUG DOSE; STEADY STATE; SUSTAINED RELEASE PREPARATION; TIME TO MAXIMUM PLASMA CONCENTRATION; TREMOR; URINARY FREQUENCY; URINE RETENTION; VITAL SIGN; VOMITING;

4-AMINOPYRIDINE; AGED; AREA UNDER CURVE; BODY WEIGHT; DELAYED-ACTION PREPARATIONS; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HALF-LIFE; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; POTASSIUM CHANNEL BLOCKERS;

EID: 71549172199     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/j.clinthera.2009.10.007     Document Type: Article

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