Hydroxycitric acid lactone and its salts: Preparation and appetite suppression studies

Food Chemistry

Volumn 120, Issue 1, 2010, Pages 235-239

  Venkateswara Rao, G ^a   Karunakara, A C ^a   Santhosh Babu, R R ^a   Ranjit, D ^a   Chandrasekara Reddy, G ^a  

^a JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

Appetite suppression; Hydroxycitric acid lactone; In vivo studies; Weight reduction

Indexed keywords

ANOREXIGENIC AGENT; HYDROXYCITRIC ACID; HYDROXYCITRIC ACID LACTONE; HYDROXYCITRIC ACID TRISODIUM SALT; INORGANIC SALT; LACTONE; METAL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FOOD INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; RAT; ROOM TEMPERATURE; WEIGHT GAIN; WEIGHT REDUCTION;

ANIMALIA; RATTUS;

EID: 71549155937     PISSN: 03088146     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.foodchem.2009.10.014     Document Type: Article

References (18)

1. Balasubramanyam, K., Chandrasekar, B., Romados, C. S., Subba Rao, P. V. (2000). Soluble double salt of group IA and IIA of (-) hydroxycitric acid, process of preparing and other food products without effecting their flavor and properties. US Patent 6395296, 2000. Chemical Abstracts, 134, 28742.
2. Conte A.A. The effects, of (-) Hydroxycitrate and chromium (GTF) on obesity. Journal of the American College of Nutrition 13 (1994) 535
3. Hayamizu K., Ishii Y., Kaneko I., Shen M., Okuhara Y., Shigematsu N., et al. Effects of Garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: A double-blind, randomized, placebo-controlled trial. Current Therapeutic Research 64 (2003) 551-567
4. Heymsfield S.B., Allison D.B., Vaselli J.R., Pietrobelli A., Greenfield D., and Nunez C. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: A randomized controlled trail. Journal of American Medical Association 280 (1998) 1596-1600
5. Hobbs L.S. (-)-Hydroxycitrate (HCA) the new diet pill (1994), Pragmatic Press, Irvine, Calif pp. 161-174
6. Krishnamurthy, N., Ravindranath, B., Sathyagalam, R. (1988). Isolation of (-) hydroxycitric acid from Garcinia rind. Indian Patent # 160753, 1988. Chemical Abstracts, 108, 203575.
7. Lewis Y.S. Preparation of soluble tripotassium salt of (-) hydroxyctric acid. Methods in Enzymology 13 (1967) 613
8. Lewis Y.S., and Neelakantan S. (-) Hydroxycitric acid: The principal acid in the fruit of Garcinia cambogia. Phytochemistry 54 (1965) 610-625
9. Lowenstein J.M. Effect of (-)-hydroxycitrate on fatty acid synthesis by rat liver in vivo. Journal of Biological Chemistry 246 (1971) 629-632
10. Nageswara Rao R., and Sakeriak K.K. Lipid-lowering and antiobesity effect of (-)-hydroxycitric acid. Nutrition Research 8 (1988) 209-212
11. Saito M., Ueno M., Ogino S., Kubo K., Nagata J., and Takeuchi M. High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food and Chemical Toxicology 43 (2005) 411-419
12. Sudarshan M., Srijita B.M., Venkateswara Rao G., Chandrasekara Reddy G., and Guru Row T.N. Garcinia Lactone. Acta Crystallographica E63 (2007) 3869
13. Sullivan A.C., Triscari J., Hamilton J.G., and Neal Miller O. The influence of (-)-hydroxycitrate upon the accumulation of lipid in the rat: Appetite. Lipids 9 (1973) 129-134
14. Sullivan A.C., Triscari J., and Neal Miller O. The influence of (-)-hydroxycitrate on in vivo rates of hepatic glycogenesis:lipogenesis and cholesterol-genesis. Federation Proceedings 33 (1974) 656
15. Thom E. (-) Hydroxycitrate in the treatment of obesity. International Journal of Obesity 20 (1996) 48
16. Venkateswara Rao, G., Karunakara, A. C., Manoj, M. N., Kush, A. K., Chandrasekara Reddy, G. (2008). High purity (-) hydroxycitric acid metal salt derivatives and method of preparation of the same. WO 2008099413, 2008. Chemical Abstracts, 148, 262854.
17. Watson J.A., Fang M., and Lowenstein J.M. Tricarballylate and hydroxycitrate:substrate and inhibitor of ATP:citrate oxaloacetate lyase. Archives of Biochemistry and Biophysics 35 (1969) 209-217
18. Watson J.A., and Lowenstein J.M. Citrate and the conversion of carbohydrate into fat. Journal of Biological Chemistry 245 (1970) 5993-6002