Human rRNA gene clusters are recombinational hotspots in cancer

Cancer Research

Volumn 69, Issue 23, 2009, Pages 9096-9104

  Stults, Dawn M ^a,b   Killen, Michael W ^b   Williamson, Erica P ^a   Hourigan, Jon S ^a,b,c   Vargas, H David ^a,b,c   Arnold, Susanne M ^b,c   Moscow, Jeffrey A ^b,c   Pierce, Andrew J ^a,b,c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; RIBOSOME DNA; RIBOSOME RNA;

ADULT; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; B CELL LEUKEMIA; BLOOD; CANCER DIAGNOSIS; CANCER RADIOTHERAPY; CANCER SURGERY; CHILD; CHILDHOOD LEUKEMIA; CLINICAL TRIAL; COLORECTAL CANCER; DIAGNOSTIC VALUE; DISEASE COURSE; DNA DETERMINATION; GENE CLUSTER; GENE FREQUENCY; GENE REARRANGEMENT; GENETIC RECOMBINATION; GENOME; GENOMIC INSTABILITY; GENOMICS; HUMAN; KARYOTYPE; LUNG CANCER; MALE; MULTICENTER STUDY; NEOPLASM; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; SOLID TUMOR; TUMOR LOCALIZATION;

ADENOCARCINOMA; ADULT; CARCINOMA, SQUAMOUS CELL; CHILD; COLORECTAL NEOPLASMS; DNA, RIBOSOMAL; GENES, RRNA; GENOMIC INSTABILITY; HUMANS; LEUKEMIA; LUNG NEOPLASMS; MULTIGENE FAMILY; RECOMBINATION, GENETIC;

EID: 71549154379     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-2680     Document Type: Article

References (24)

1. Worton RG, Sutherland J, Sylvester JE, et al. Human ribosomal RNA genes: orientation of the tandem array and conservation of the 5′ end. Science 1988;239:64-68 (Pubitemid 18029498)
2. Gonzalez IL, Sylvester JE. Complete sequence of the 43-kb human ribosomal DNA repeat: analysis of the intergenic spacer. Genomics 1995;27:320-328
3. Stults DM, Killen MW, Pierce HH, Pierce AJ. Genomic architecture and inheritance of human ribosomal RNA gene clusters. Genome Res 2008;18:13-18
4. Reliene R, Bishop AJ, Schiestl RH. Involvement of homologous recombination in carcinogenesis. Adv Genet 2007;58:67-87.
5. Killen MW, Stults DM, Adachi N, Hanakahi L, Pierce AJ. Loss of Bloom syndrome protein destabilizes human gene cluster architecture. Hum Mol Genet 2009;18:3417-3428
6. NCI. Ataxia Telangiectasia: Fact Sheet. National Cancer Institute; 2009, Available from: http://www.cancer.gov/cancertopics/factsheet/ataxiaqa.
7. German J. Bloom's syndrome. XX. The first 100 cancers. Cancer Genet Cytogenet 1997;93:100-106
8. ACS. Cancer facts and figures 2009. American Cancer Society; 2009, Available from: http://www.cancer.org/downloads/STT/500809web.pdf.
9. DeMarini DM. Genotoxicity of tobacco smoke and tobacco smoke condensate: a review. Mutat Res 2004;567:447-474 (Pubitemid 39574548)
10. Hopkin JM. Sister chromatid exchange induction by cigarette smoke. Basic Life Sci 1984;29 Pt B:927-937
11. Hopkins JM, Evans HJ. Cigarette smoke-induced DNA damage and lung cancer risks. Nature 1980;283:388-390
12. Wilson DMIII, Thompson LH. Molecular mechanisms of sister-chromatid exchange. Mutat Res 2007;616:11-23.
13. Johnson RD, Jasin M. Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells. EMBO J 2000;19:3398-3407 (Pubitemid 30428217)
14. Richardson C, Jasin M. Coupled homologous and nonhomologous repair of a double-strand break preserves genomic integrity in mammalian cells. Mol Cell Biol 2000;20:9068-9075 (Pubitemid 32245935)
15. Saviozzi S, Ceppi P, Novello S, et al. Non-small cell lung cancer exhibits transcript overexpression of genes associated with homologous recombination and DNA replication pathways. Cancer Res 2009;69:3390-3396
16. Ding L, Getz G, Wheeler DA, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008;455:1069-1075
17. Moscow JA, Cowan KH. Biology of Cancer. In: Goldman L, Ausiello D, editors. Cecil Medicine. 23rd ed. Philadelphia (PA): Saunders Elsevier; 2008, p. 1345-1348
18. Melamed MR, Adams LR, Traganos F, Zimring A, Kamentsky LA. Acridine orange metachromasia for characterization of leukocytes in leukemia, lymphoma, and other neoplasms. Cancer 1972;29:1361-1368
19. Lu Y, Chang Q, Zhang Y, et al. Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3. Cell Cycle 2009;8.
20. Shaw CJ, Lupski JR. Implications of human genome architecture for rearrangement-based disorders: the genomic basis of disease. Hum Mol Genet 2004;13 Spec No 1:R57-64.
21. Grigorova M, Lyman RC, Caldas C, Edwards PA. Chromosome abnormalities in 10 lung cancer cell lines of the NCI-H series analyzed with spectral karyotyping. Cancer Genet Cytogenet 2005;162:1-9. (Pubitemid 41278464)
22. Warburton PE, Hasson D, Guillem F, Lescale C, Jin X, Abrusan G. Analysis of the largest tandemly repeated DNA families in the human genome. BMC Genomics 2008;9:533.
23. LICR. CTdatabase. Ludwig Institute for Cancer Research; 2009, Available from: http://www.cta.lncc.br/.
24. Wiese C, Pierce AJ, Gauny SS, Jasin M, Kronenberg A. Gene conversion is strongly induced in human cells by double-strand breaks and is modulated by the expression of BCL-x(L). Cancer Res 2002;62:1279-1283