Enzyme-assisted kinetic resolution of novel 2-naphthol Mannich bases

Journal of Molecular Catalysis B: Enzymatic

Volumn 62, Issue 1, 2010, Pages 46-53

  Mukherjee, Chandrani ^a   MacLean, Erin D ^a   Cameron, T Stanley ^b   Jha, Amitabh ^a  

^a ACADIA UNIVERSITY   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

2 Naphthol Mannich bases; Biotransformations; Enzyme assisted kinetic resolution; Novozyme 435 ; SERMs; Transesterification; X ray crystallography

Indexed keywords

2-NAPHTHOL MANNICH BASES; 2-NAPHTHOLS; AROMATIC ALDEHYDE; CHEMO-AND REGIOSELECTIVITIES; ENANTIOSELECTIVE; KINETIC RESOLUTION; LIPASE B FROM CANDIDA ANTARCTICA; MANNICH REACTIONS; NOVOZYME 435; RACEMIC MIXTURES; SELECTIVE ESTROGEN RECEPTOR MODULATORS;

ACETYLATION; ALDEHYDES; ENZYMES; MINERALOGY; OPTICAL ROTATION; PHENOLS; SELF ASSEMBLY; STEREOCHEMISTRY;

X RAY CRYSTALLOGRAPHY;

1 [(3,4 DICHLOROPHENYL)(2 HYDROXYNAPHTHALEN 1 YL)METHYL]PIPERIDIN 4 OL; 1 [(3,4 DICHLOROPHENYL)(2 HYDROXYNAPHTHALEN 1 YL)METHYL]PIPERIDIN 4 YL ACETIC ACID; 1 [(4 CHLOROPHENYL)(2 HYDROXYNAPHTHALEN 1 YL)METHYL]PIPERIDIN 4 OL; 1 [(4 CHLOROPHENYL)(2 HYDROXYNAPHTHALEN 1 YL)METHYL]PIPERIDIN 4 YL ACETIC ACID; 1 [(4 FLUOROPHENYL)(2 HYDROXYNAPHTHALEN 1 YL)METHYL]PIPERIDIN 4 OL; 1 [(4 FLUOROPHENYL)(2 HYDROXYNAPHTHALEN 1 YL)METHYL]PIPERIDIN 4 YL ACETIC ACID; 1 [(BENZO[D][1,3]DIOXOL 5 YL)(2 HYDROXYNAPHTHALEN 1 YL)METHYL]PIPERIDIN 4 OL; 1 [(BENZO[D][1,3]DIOXOL 5 YL)(2 HYDROXYNAPHTHALEN 1 YL)METHYL]PIPERIDIN 4 YL ACETIC ACID; 1 [2 (HYDROXYNAPHTHALEN 1 YL)(3,4 DIMETHOXYPHENYL)METHYL]PIPERIDIN 4 OL; 1 [2 (HYDROXYNAPHTHALEN 1 YL)(3,4 DIMETHOXYPHENYL)METHYL]PIPERIDIN 4 YL ACETIC ACID; 1 [2 (HYDROXYNAPHTHALEN 1 YL)(4 METHOXYPHENYL)METHYL]PIPERIDIN 4 OL; 1 [2 (HYDROXYNAPHTHALEN 1 YL)(4 METHOXYPHENYL)METHYL]PIPERIDIN 4 YL ACETIC ACID; 1 [2 (HYDROXYNAPHTHALEN 1 YL)(4 TOLYL)METHYL]PIPERIDIN 4 OL; 1 [2 (HYDROXYNAPHTHALEN 1 YL)(4 TOLYL)METHYL]PIPERIDIN 4 YL ACETIC ACID; 1 [2 (HYDROXYNAPHTHALEN 1 YL)(PHENYL)METHYL]PIPERIDIN 4 OL; 1 [2 (HYDROXYNAPHTHALEN 1 YL)(PHENYL)METHYL]PIPERIDIN 4 YL ACETIC ACID; 1 [2 (HYDROXYNAPHTHALEN 1 YL)(PYRIDIN 2 YL)METHYL]PIPERIDIN 4 OL; 1 [2 (HYDROXYNAPHTHALEN 1 YL)(PYRIDIN 2 YL)METHYL]PIPERIDIN 4 YL ACETIC ACID; 1 [2 (HYDROXYNAPHTHALEN 1 YL)(PYRIDIN 4 YL)METHYL]PIPERIDIN 4 OL; 1 [2 (HYDROXYNAPHTHALEN 1 YL)(PYRIDIN 4 YL)METHYL]PIPERIDIN 4 YL ACETIC ACID; 1 [2 (HYDROXYNAPHTHALEN 1 YL)ARYLMETHYL]PIPERIDIN 4 YL ACETIC ACID; MANNICH BASE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; BIOTRANSFORMATION; CHIRALITY; DRUG DESIGN; DRUG STRUCTURE; ENANTIOSELECTIVITY; ENZYME KINETICS; STRUCTURE ANALYSIS; TRANSESTERIFICATION; X RAY CRYSTALLOGRAPHY;

CANDIDA ANTARCTICA;

EID: 71549152835     PISSN: 13811177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcatb.2009.09.001     Document Type: Article

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