In vitro biological evaluation of biguanides and dihydrotriazines against Brugia malayi and folate reversal studies

Acta Tropica

Volumn 113, Issue 1, 2010, Pages 48-51

  Bag, Seema ^a   Tawari, Nilesh R ^a   Sharma, Richa ^b   Goswami, Kalyan ^b   Reddy, M V R ^b   Degani, Mariam S ^a  

^a INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b MAHATMA GANDHI INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Antifilarial; Biguanides; Brugia malayi; DHFR inhibitors; Dihydrotriazines

Indexed keywords

A1 01; A1 02; A1 03; A1 04; A2 01; A2 02; A2 03; A2 04; ANTIFILARIAL AGENT; ANTIINFECTIVE AGENT; ANTIMALARIAL AGENT; B1 01; B1 02; B1 03; B1 04; B1 05; B1 06; B1 07; B2 01; BIGUANIDE DERIVATIVE; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; DIHYDROTRIAZINE DERIVATIVE; FOLIC ACID; FOLIC ACID ANTAGONIST; FOLINIC ACID; PYRIMETHAMINE; TRIAZINE DERIVATIVE; TRIMETHOPRIM; UNCLASSIFIED DRUG; UNINDEXED DRUG;

DISEASE; DRUG; ENZYME; PARASITE CONTROL; PROTOZOAN;

ANTIMICROBIAL THERAPY; ARTICLE; BRUGIA MALAYI; BRUGIAN FILARIASIS; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; IN VITRO STUDY; METAZOON; MICROFILARIA; NONHUMAN; PROTOZOON;

ANIMALS; BIGUANIDES; BRUGIA MALAYI; FILARIASIS; FILARICIDES; FOLIC ACID ANTAGONISTS; PYRIMETHAMINE; TETRAHYDROFOLATE DEHYDROGENASE; TRIAZINES; TRIMETHOPRIM;

BRUGIA MALAYI; METAZOA; PROTOZOA;

EID: 71549124678     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actatropica.2009.09.004     Document Type: Article

References (14)

1. Ash L.R., and Riley J.M. Development of subperiodic Brugia malayi in the jird, Meriones unguiculatus, with notes on infections in other rodents. J. Parasitol. 56 (1970) 969-973
2. Blaney J.M., Hansch C., Silipo C., and Vittoria A. Structure-activity relationships of dihydrofolate reductase inhibitors. Chem. Rev. 84 (1984) 333-407
3. Bag, S., Tawari, N.R., Degani, M.S., Queener, S.F., Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms. J. Enzym. Inhib. Med. Chem., in press.
4. Chandrasekhar R., Rao U.R., Rajasekhariah G.R., and Subrahmanyam D. Isolation of microfilariae from blood on iso-osmotic percoll gradients. Indian J. Med. Res. 79 (1984) 497-501
5. Gangjee A., Kurup S., and Namjoshi O. Dihydrofolate reductase as target for chemotherapy in parasites. Curr. Pharm. Des. 13 (2007) 609-639 references therein
6. Gupta S., and Srivastava A.K. Biochemical targets in filarial worms for selective antifilarial drug design. Acta Parasitol. 50 (2005) 1-18
7. Heidi S.L. Investigating development of infective stage larvae of filarial nematodes. Front. Biosci. 5 (2000) E95-E102
8. Kinyanjui S.M., Mberu E.K., Winstanley P.A., Jacobus D.P., and Watkins W.M. The antimalarial triazine WR99210 and the prodrug PS-15: folate reversal of in vitro activity against Plasmodium falciparum and a non-antifolate mode of action of the prodrug. Am. J. Trop. Med. Hyg. 60 (1999) 943-947
9. Navarro-Perán E., Cabezas-Herrera J., García-Cánovas F., Durrant M.C., Thorneley R.N.F., and Rodríguez-López N.J. The antifolate activity of tea catechins. Cancer Res. 65 (2005) 2059-2064
10. Sahare K.N., Anandharaman V., Meshram V.G., Meshram S.U., Reddy M.V.R., Tumane P.M., and Goswami K. Antimicrofilarial activity of methanolic extract of Vitex negundo and Aegle marmelos and their phytochemical analysis. Indian J. Exp. Biol. 46 (2008) 128-131
11. Sanger I., Lammler G., and Kimmig P. Filarial infection of Mastomys natelansis and their relevance for experimental chemotherapy. Acta Trop. 38 (1981) 277-288
12. Sharma R.D., Janardhanan, Abhilash S., Gajalakshmi D., Reddy V.R., and Goswami K. Direct microscopy: an alternative tool for assessment of viability of microfilariae. Internet J. Parasitic Dis. (2008) 3
13. Subrahmanyam D. Problems in filariasis: current approaches in development of antifilarials. In: Dunsmore J.D. (Ed). Tropical Parasitoses and Parasitic Zoonoses, Proceedings of the 10th International Conference of World Association for the Advancement of Veterinary Parasitology. Perth, Australia (1983) 107-123
14. Tripathi R.P., Katiyar D., Dwivedi N., Singh B.K., and Pandey J. Recent developments in search of antifilarial agents. Curr. Med. Chem. 13 (2006) 3319-3334