Modified radical hysterectomy versus extrafascial hysterectomy in the treatment of stage i endometrial cancer: Results from the ILIADE randomized study

Annals of Surgical Oncology

Volumn 16, Issue 12, 2009, Pages 3431-3441

  Signorelli, Mauro ^a   Lissoni, Andrea Alberto ^a   Cormio, Gennaro ^b   Katsaros, Dionyssios ^c   Pellegrino, Antonio ^a   Selvaggi, Luigi ^b   Ghezzi, Fabio ^d   Scambia, Giovanni ^e   Zola, Paolo ^f   Grassi, Roberto ^g   Milani, Rodolfo ^a   Giannice, Raffaella ^h   Caspani, Giovanna ⁱ   Mangioni, Costantino ^a   Floriani, Irene ^j   Rulli, Eliana ^j   Fossati, Roldano ^j  

^a SAN GERARDO HOSPITAL   (Italy)

^b UNIVERSITY OF BARI   (Italy)

^c POLITECNICO DI TORINO   (Italy)

^d UNIVERSITY OF INSUBRIA   (Italy)

^e FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

^f MAURIZIANO HOSPITAL   (Italy)

^g TREVIGLIO HOSPITAL   (Italy)

^h HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

ⁱ A MANZONI HOSPITAL   (Italy)

^j MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALGORITHM; ARTICLE; CANCER RADIOTHERAPY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; EARLY CANCER; ENDOMETRIUM CANCER; FEMALE; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; OPERATION DURATION; OUTCOME ASSESSMENT; OVERALL SURVIVAL; POSTOPERATIVE CARE; PROGNOSIS; RADICAL HYSTERECTOMY; RANDOMIZED CONTROLLED TRIAL; RECURRENCE RISK; RECURRENT CANCER; SURGICAL TECHNIQUE; TREATMENT PLANNING;

ADENOCARCINOMA, CLEAR CELL; ADENOCARCINOMA, MUCINOUS; ADOLESCENT; ADULT; AGED; CARCINOMA, ADENOSQUAMOUS; CYSTADENOCARCINOMA, SEROUS; ENDOMETRIAL NEOPLASMS; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYSTERECTOMY; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; SURVIVAL RATE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 71549121973     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-009-0736-6     Document Type: Article

References (36)

1. A Jemal R Siegel E Ward, et al. 2008 Cancer statistics, 2008 CA Cancer J Clin 58 71 76 10.3322/CA.2007.0010 18287387
2. J Aalders V Abeler P Kolstad M Onsrud 1980 Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma Obstet Gynaecol 56 419 427 1:STN:280:DyaL3M%2FjtFChsQ%3D%3D
3. CL Creutzberg WL van Putten PC Koper, et al. 2000 Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma Lancet 355 9213 1404 1411 10.1016/S0140-6736(00)02139-5 1:STN:280:DC%2BD3c3ltVWlsQ%3D%3D 10791524
4. HM Keys JA Roberts VL Brunetto Gynecologic Oncology Group, et al. 2004 A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study Gynecol Oncol 92 744 751 10.1016/j.ygyno.2003.11.048 14984936 (Pubitemid 38251372)
5. The ASTEC/EN.5 Writing Committee on behalf of the ASTEC/EN.5 Study Group 2009 Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis Lancet 373 9658 137 146 10.1016/S0140-6736(08)61767-5
6. A Mariani SC Dowdy GL Keeney, et al. 2005 Predictors of vaginal relapse in stage I endometrial cancer Gynecol Oncol 97 820 827 10.1016/j.ygyno.2005.03. 008 15894363 (Pubitemid 40824652)
7. P Elliott D Green A Coates, et al. 1994 The efficacy of postoperative vaginal irradiation in preventing vaginal recurrence in endometrial cancer Int J Gynecol Cancer 4 84 93 10.1046/j.1525-1438.1994.04020084.x 11578390 (Pubitemid 24179776)
8. KM Alektiar A McKee E Venkatraman, et al. 2002 Intravaginal high-dose-rate brachytherapy for Stage IB (FIGO Grade 1, 2) endometrial cancer Int J Radiat Oncol Biol Phys 53 707 713 12062616
9. CL Creutzberg WL van Putten CC Wárlám-Rodenhuis, et al. 2004 Postoperative Radiation Therapy in Endometrial Carcinoma Trial. Outcome of high-risk stage IC, grade 3, compared with stage I endometrial carcinoma patients: the Postoperative Radiation Therapy in Endometrial Carcinoma Trial J Clin Oncol 22 1234 1241 10.1200/JCO.2004.08.159 15051771 (Pubitemid 41079837)
10. AN Scholten WL van Putten H Beerman PORTEC Study Group, et al. 2005 Postoperative radiotherapy for Stage 1 endometrial carcinoma: long-term outcome of the randomized PORTEC trial with central pathology review Int J Radiat Oncol Biol Phys 63 834 838 15927414
11. CL Creutzberg WL van Putten PC Koper PORTEC Study Group, et al. 2001 The postoperative radiation therapy in endometrial carcinoma. The morbidity of treatment for patients with Stage I endometrial cancer: results from a randomized trial Int J Radiat Oncol Biol Phys 51 1246 1255 1:STN:280: DC%2BD3Mnot1yntA%3D%3D 11728684
12. TY Ng LC Perrin JL Nicklin R Cheuk AJ Crandon 2000 Local recurrence in high-risk node-negative stage I endometrial carcinoma treated with postoperative vaginal vault brachytherapy Gynecol Oncol 79 490 494 10.1006/gyno.2000.6005 1:STN:280:DC%2BD3M%2Fnt1CqsA%3D%3D 11104626
13. M Chadha PJ Nanavati P Liu J Fanning A Jacobs 1999 Patterns of failure in endometrial carcinoma stage IB grade 3 and IC patients treated with postoperative vaginal vault brachytherapy (review) Gynecol Oncol 75 103 107 10.1006/gyno.1999.5526 1:STN:280:DyaK1MvjsVSqsg%3D%3D 10502434 (Pubitemid 29477810)
14. NS Horowitz WA Peters 3rd MR Smith, et al. 2002 Adjuvant high dose rate vaginal brachytherapy as treatment of stage I and II endometrial carcinoma Obstet Gynecol 99 235 240 10.1016/S0029-7844(01)01672-6 11814503 (Pubitemid 34113995)
15. B Röper ST Astner A Heydemann-Obradovic, et al. 2007 Ten-year data on 138 patients with endometrial carcinoma and postoperative vaginal brachytherapy alone: no need for external-beam radiotherapy in low and intermediate risk patients Gynecol Oncol 107 541 548 10.1016/j.ygyno.2007.08.055 17884152 (Pubitemid 350167465)
16. S Jolly C Vargas T Kumar, et al. 2005 Vaginal brachytherapy alone: an alternative to adjuvant whole pelvis radiation for early stage endometrial cancer Gynecol Oncol 97 887 892 10.1016/j.ygyno.2005.02.021 15943991 (Pubitemid 40824661)
17. PV Rittenberg RJ Lotocki MS Heywood KD Jones GV Krepart 2003 High-risk surgical stage 1 endometrial cancer: outcomes with vault brachytherapy alone Gynecol Oncol 89 288 294 10.1016/S0090-8258(03)00085-4 12713993 (Pubitemid 36457878)
18. Vaginal brachytherapy versus external beam pelvic radiotherapy for high-intermediate risk endometrial cancer: results of the randomized PORTEC-2 trial (abstract LBA5503). Paper presented at: 2008 ASCO Annual Meeting, Chicago, IL.
19. KM Greven RM Lanciano SH Herbert PE Hogan 1991 Analysis of complications in patients with endometrial carcinoma receiving adjuvant irradiation Int J Radiat Oncol Biol Phys 21 919 923 1:STN:280:DyaK38%2FhtFSntQ%3D%3D 1917620
20. JM Anderson B Stea AV Hallum E Rogoff J Childers 2000 High-dose-rate postoperative vaginal cuff irradiation alone for stage IB and IC endometrial cancer Int J Radiat Oncol Biol Phys 46 417 425 10.1016/S0360-3016(99)00427-7 1:STN:280:DC%2BD3c7isV2ltw%3D%3D 10661349 (Pubitemid 30067792)
21. MS Piver FN Rutledge JP Smith 1974 Five classes of extended hysterectomy of women with cervical cancer Obstet Gynecol 44 265 270 1:STN:280: DyaE2M%2FhslOgtQ%3D%3D 4417035
22. F Landoni A Maneo A Colombo, et al. 1997 Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancer Lancet 350 9077 535 540 10.1016/S0140-6736(97)02250-2 1:STN:280:DyaK2svjtVKltQ%3D%3D 9284774 (Pubitemid 27348428)
23. CT Javert RG Douglas 1956 Treatment of endometrial adenocarcinoma; a study of 381 cases at the New York Hospital; a preliminary report Am J Roentgenol Radium Ther Nucl Med 75 508 514 1:STN:280:DyaG28%2FksVymsQ%3D%3D 13292599
24. FN Rutledge 1974 The role of radical hysterectomy in adenocarcinoma of the endometrium Gynecol Oncol 2 331 347 10.1016/0090-8258(74)90024-9 1:STN:280:DyaE2M7jtF2qsg%3D%3D 4218187
25. J Pagel JE Bock 1984 Endometrial cancer. A review Dan Med Bull 31 333 345 1:STN:280:DyaL2M%2Fgt12itQ%3D%3D 6383739
26. E Sartori A Gadducci F Landoni, et al. 2001 Clinical behavior of 203 stage II endometrial cancer cases: the impact of primary surgical approach and of adjuvant radiation therapy Int J Gynecol Cancer 11 430 437 10.1046/j.1525-1438.2001.01061.x 1:STN:280:DC%2BD387nvFyktQ%3D%3D 11906545 (Pubitemid 34024800)
27. DE Cohn EM Woeste S Cacchio, et al. 2007 Clinical and pathologic correlates in surgical stage II endometrial carcinoma Obstet Gynecol 109 1062 1067 17470583
28. GH Eltabbakh AD Moore 1999 Survival of women with surgical stage II endometrial cancer Gynecol Oncol 74 80 85 10.1006/gyno.1999.5454 1:STN:280:DyaK1MzjtlOmug%3D%3D 10385555 (Pubitemid 29331171)
29. T Maggino C Romagnolo P Zola, et al. 1995 An analysis of approaches to the treatment of endometrial cancer in Western Europe: a CTF study Eur J Cancer. 31 1993 1997 10.1016/0959-8049(95)00316-9 (Pubitemid 26023089)
30. PB Panici S Basile F Maneschi, et al. 2008 Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial J Natl Cancer Inst 100 1707 1716 10.1093/jnci/djn397
31. WK Huh JM Straughn Jr A Mariani, et al. 2007 Salvage of isolated vaginal recurrences in women with surgical stage I endometrial cancer: a multiinstitutional experience Int J Gynecol Cancer 17 886 889 10.1111/j.1525-1438.2007.00858.x 1:STN:280:DC%2BD2svhsFGhsg%3D%3D 17309665 (Pubitemid 47063322)
32. CL Creutzberg WL van Putten PC Koper PORTEC Study Group, et al. 2003 Survival after relapse in patients with endometrial cancer: results from a randomized trial Gynecol Oncol 89 201 209 10.1016/S0090-8258(03)00126-4 12713981 (Pubitemid 36457866)
33. H Arndt-Miercke A Martin V Briese, et al. 2008 Transection of vaginal cuff is an independent prognostic factor in stage I endometrial cancer Eur J Surg Oncol 34 241 246 1:STN:280:DC%2BD1c%2FltVCqtQ%3D%3D 17822868
34. F Landoni A Maneo G Cormio, et al. 2001 Class II versus class III radical hysterectomy in stage Ib-IIa cervical cancer: a prospective randomized study Gynecol Oncol 80 3 12 10.1006/gyno.2000.6010 1:STN:280:DC%2BD3M7gtFensw%3D%3D 11136561 (Pubitemid 32062080)
35. F Raspagliesi A Ditto R Fontanelli, et al. 2006 Type II versus type III nerve-sparing radical hysterectomy: comparison of lower urinary tract dysfunctions Gynecol Oncol 102 256 262 10.1016/j.ygyno.2005.12.014 16445968 (Pubitemid 44041639)
36. P Zola T Maggino M Sacco, et al. 2000 Prospective multicenter study on urologic complications after radical surgery with or without radiotherapy in the treatment of stage IB-IIA cervical cancer Int J Gynecol Cancer 10 59 66 10.1046/j.1525-1438.2000.99074.x 11240652 (Pubitemid 30219479)