The acute and subchronic effects of a brain-penetrating, neurotensin-1 receptor agonist on feeding, body weight and temperature

Neuropharmacology

Volumn 58, Issue 1, 2010, Pages 195-198

  Feifel, David ^a   Goldenberg, Joseph ^a   Melendez, Gilia ^a   Shilling, Paul D ^a  

^a UCSD MEDICAL CENTER   (United States)

Author keywords

Feeding; Neurotensin; Obesity; PD149163

Indexed keywords

CENTRAL STIMULANT AGENT; LEPTIN; NEUROTENSIN RECEPTOR; PD 149163; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; BROWN NORWAY RAT; COGNITION; CONTROLLED STUDY; CORE TEMPERATURE; DRUG EFFICACY; DRUG PENETRATION; DRUG TOLERABILITY; FEEDING; FOOD INTAKE; HYPOTHERMIA; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; THERMOREGULATION; TRANQUILIZING ACTIVITY; WEIGHT REDUCTION;

ANALYSIS OF VARIANCE; ANIMALS; ANTIPSYCHOTIC AGENTS; BODY TEMPERATURE; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; EATING; MALE; MICE; MICE, OBESE; NEUROTENSIN; RATS; RECEPTORS, NEUROTENSIN; TIME FACTORS;

EID: 71549120350     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2009.07.001     Document Type: Article

References (25)

1. Azmi N., Norman C., Spicer C.H., and Bennett G.W. Effects of a neurotensin analogue (PD149163) and antagonist (SR142948A) on the scopolamine-induced deficits in a novel object discrimination task. Behav. Pharmacol. 17 (2006) 357-362
2. Beck B., Stricker-Krongrad A., Richy S., and Burlet C. Evidence that hypothalamic neurotensin signals leptin effects on feeding behavior in normal and fat-preferring rats. Biochem. Biophys. Res. Commun. 252 (1998) 634-638
3. Bissette G., Nemeroff C.B., Loosen P.T., Prange Jr. A.J., and Lipton M.A. Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensin. Nature 262 (1976) 607-609
4. Boules M., Cusack B., Zhao L., Fauq A., McCormick D.J., and Richelson E. A novel neurotensin peptide analog given extracranially decreases food intake and weight in rodents. Brain Res. 865 (2000) 35-44
5. Boules M., Fredrickson P., and Richelson E. Neurotensin agonists as an alternative to antipsychotics. Expert Opin. Investig. Drugs. 14 (2005) 359-369
6. Boules M., McMahon B., Wang R., Warrington L., Stewart J., Yerbury S., Fauq A., McCormick D., and Richelson E. Selective tolerance to the hypothermic and anticataleptic effects of a neurotensin analog that crosses the blood-brain barrier. Brain Res. 987 (2003) 39-48
7. Cooke, J.H., Patterson, M., Patel, S.R., Smith, K.L., Ghatei, M.A., Bloom, S.R., Murphy, K.G., 2009. Peripheral and Central Administration of Xenin and Neurotensin Suppress Food Intake in Rodents. Obesity (Silver Spring).
8. Feifel D., Melendez G., Murray R.J., Tina Tran D.N., Rullan M.A., and Shilling P.D. The reversal of amphetamine-induced locomotor activation by a selective neurotensin-1 receptor agonist does not exhibit tolerance. Psychopharmacology (Berl) 200 (2008) 197-203
9. Feifel D., Melendez G., Priebe K., and Shilling P.D. The effects of chronic administration of established and putative antipsychotics on natural prepulse inhibition deficits in Brattleboro rats. Behav. Brain Res. 81 (2007) 278-286
10. Feifel D., Melendez G., and Shilling P.D. A systemically administered neurotensin agonist blocks disruption of prepulse inhibition produced by a serotonin-2A agonist. Neuropsychopharmacology 28 (2003) 651-653
11. Feifel D., Melendez G., and Shilling P.D. Reversal of sensorimotor gating deficits in Brattleboro rats by acute administration of clozapine and a neurotensin agonist, but not haloperidol: a potential predictive model for novel antipsychotic effects. Neuropsychopharmacology 29 (2004) 731-738
12. Feifel D., Mexal S., Melendez G., Liu P.Y., Goldenberg J.R., and Shilling P.D. The Brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analog. Neuropsychopharmacology (2009)
13. Feifel D., Reza T.L., Wustrow D.J., and Davis M.D. Novel antipsychotic-like effects on prepulse inhibition of startle produced by a neurotensin agonist. J. Pharmacol. Exp. Ther. 288 (1999) 710-713
14. Hawkins M.F. Central nervous system neurotensin and feeding. Physiol. Behav. 36 (1986) 1-8
15. Kim E.R., Leckstrom A., and Mizuno T.M. Impaired anorectic effect of leptin in neurotensin receptor 1-deficient mice. Behav. Brain Res. 194 (2008) 66-71
16. Levine A.S., Kneip J., Grace M., and Morley J.E. Effect of centrally administered neurotensin on multiple feeding paradigms. Pharmacol. Biochem. Behav. 18 (1983) 19-23
17. Lin S., and Huang X.F. Fasting increases leptin receptor mRNA expression in lean but not obese (ob/ob) mouse brain. Neuroreport 8 (1997) 3625-3629
18. Luttinger D., King R.A., Sheppard D., Strupp J., Nemeroff C.B., and Prange Jr. A.J. The effect of neurotensin on food consumption in the rat. Eur. J. Pharmacol. 81 (1982) 499-503
19. Ohinata K., Shimano T., Yamauchi R., Sakurada S., Yanai K., and Yoshikawa M. The anorectic effect of neurotensin is mediated via a histamine H1 receptor in mice. Peptides 25 (2004) 2135-2138
20. Pelaprat D. Interactions between neurotensin receptors and G proteins. Peptides 27 (2006) 2476-2487
21. Petrie K.A., Bubser M., Casey C.D., Davis M.D., Roth B.L., and Deutch A.Y. The neurotensin agonist PD149163 increases Fos expression in the prefrontal cortex of the rat. Neuropsychopharmacology 29 (2004) 1878-1888
22. Remaury A., Vita N., Gendreau S., Jung M., Arnone M., Poncelet M., Culouscou J.M., Le Fur G., Soubrie P., Caput D., Shire D., Kopf M., and Ferrara P. Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia. Brain Res. 953 (2002) 63-72
23. Sahu A., Carraway R.E., and Wang Y.P. Evidence that neurotensin mediates the central effect of leptin on food intake in rat. Brain Res. 888 (2001) 343-347
24. Shilling P.D., and Feifel D. The neurotensin-1 receptor agonist PD149163 blocks fear-potentiated startle. Pharmacol. Biochem. Behav. 90 (2008) 748-752
25. St-Gelais F., Jomphe C., and Trudeau L.E. The role of neurotensin in central nervous system pathophysiology: what is the evidence?. J. Psychiatry Neurosci. 31 (2006) 229-245