Regulation of plasma LDL: The apoB paradigm

Clinical Science

Volumn 118, Issue 5, 2010, Pages 333-339

  Sniderman, Allan D ^a   De Graaf, Jacqueline ^b   Couture, Patrick ^c   Williams, Ken ^d   Kiss, Robert S ^a   Watts, Gerald F ^e  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c UNIVERSITÉ LAVAL   (Canada)

^d KenAnCo Biostatistics   (United States)

^e UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Apolipoprotein B; Cholesterol; Endoplasmic reticulum; Hepatocyte; Low density lipoprotein; Plasma

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; ABC TRANSPORTER A1; ACYL COENZYME A; APOLIPOPROTEIN B; LIVER X RECEPTOR ALPHA; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN; VERY LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ARTICLE; CHOLESTEROL SYNTHESIS; FIBROBLAST; HOMOZYGOSITY; HUMAN; HYPERCHOLESTEROLEMIA; IN VIVO STUDY; LIPOPROTEIN BLOOD LEVEL; LIVER CELL; PRIORITY JOURNAL; UPREGULATION;

APOLIPOPROTEINS B; CHOLESTEROL; HEPATOCYTES; HOMEOSTASIS; HUMANS; LIPOPROTEINS, LDL; MODELS, BIOLOGICAL; RECEPTORS, LDL; SIGNAL TRANSDUCTION;

EID: 71449092611     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20090402     Document Type: Article

References (22)

1. Brown, M. S. and Goldstein, J. L. (1986) A receptor-mediated pathway for cholesterol homeostasis. Science 232, 34-47
2. Fisher, W. R., Zech, L. A. and Stacpoole, P. W. (1994) ApoB metabolism in familial hypercholesterolemia. Inconsistencies with the LDL receptor paradigm. Arterioscler. Thromb. Vasc. Biol. 14, 501-510
3. Thompson, G. R., Naoumova, R. P. andWatts, G. F. (1996) Role of cholesterol in regulating apolipoprotein B secretion by the liver. J. Lipid Res. 37, 439-447
4. Cummings,M.H., Watts, G. F.,Umpleby,M., Hennessy, T. R., Quiney, J. R. and Sönksen, P. H. (1995) Increased hepatic secretion of very-low-density-lipoprotein apolipoprotein B-100 in heterozygous familial hypercholesterolaemia: a stable isotope study. Atherosclerosis 113, 79-89
5. Sniderman, A. D., Zhang, X. and Cianflone, K. (1999) Governance of the concentration of plasma LDL: a reevaluation of the LDL receptor paradigm. Atherosclerosis 148, 215-229
6. Sniderman, A. D. and Cianflone, K. (1993) Substrate delivery as a determinant of hepatic apoB secretion. Arterioscler. Thromb. Vasc. Biol. 13, 629-636
7. Goldstein, J. L. and Brown, M. S. (2009) The LDL receptor. Arterioscler. Thromb. Vasc. Biol. 29, 431-438
8. Brown, M. S. and Goldstein, J. L. (2009) Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. J. Lipid Res. 50, (Suppl.) 15-27
9. Bilheimer, D. W., Stone, N. J. and Grundy, S. M. (1979) Metabolic studies in familial hypercholesterolemia: evidence for a gene-dosage effect in vivo. J. Clin. Invest. 64, 524-533
10. Dietschy, J. M., Turley, S. D. and Spady, D. K. (1993) Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J. Lipid Res. 34, 1637-1659
11. Teng, B., Sniderman, A. D., Soutar, A. K. and Thompson, G. R. (1986) Metabolic basis of hyperapobetalipoproteinemia. Turnover of apolipoprotein B in low density lipoprotein and its precursors and subfractions compared with normal and familial hypercholesterolemia. J. Clin. Invest. 77, 663-672
12. Millar, J. S., Maugeais, C., Ikewaki, K., Kolansky, D. M., Barrett, P. H. R., Budreck, E. C., Boston, R. C., Tada, N., Mochizuki, S. and Defesche, J. C. (2005) Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production. Arterioscler. Thromb. Vasc. Biol. 25, 560-565
13. Zulewski, H., Ninnis, R., Miserez, A. R., Baumstark, M.W. and Keller, U. (1998) VLDL and IDL apolipoprotein B-100 kinetics in familial hypercholesterolemia due to impaired LDL receptor function or to defective apolipoprotein B-100. J. Lipid Res. 39, 380-387
14. Tremblay, A. J., Lamarche, B., Ruel, I. L., Hogue, J. C., Bergeron, J., Gagne, C. and Couture, P. (2004) Increased production of VLDL apoB-100 in subjects with famililial hypercholesterolemia carrying the same null LDL receptor gene mutation. J. Lipid Res. 45, 866-872
15. Kesanieimi, Y. A. and Grundy, S. M. (1982) The significance of low density lipoprotein production in the regulation of plasma cholesterol level in man. J. Clin. Invest. 70, 13-22
16. Grundy, S. M., Vega, G. L. and Bilheimer, D.W. (1985) Kinetic mechanisms determining variability in low density lipoprotein levels and rise with age. Arteriosclerosis 5, 623-630
17. Havekes, L. M., deWit, E. C.M. and Princen, H.M. (1987) Cellular free cholesterol in Hep G2 cells is only partially available for down-regulation of low-density-lipoprotein receptor activity. Biochem. J. 247, 739-746
18. Havekes, L. M., Verboom, H., de Wit, E. C. M., Yap, S. H. and Princen, H. M. (1986) Regulation of low density lipoprotein receptor activity in primary culture of human hepatocytes by serum lipoproteins. Hepatology 6, 1356-1360
19. Meddings, J. B. and Dietschy, J. M. (1986) Regulation of plasma levels of low-density lipoprotein cholesterol: interpretation of data on low-density lipoprotein turnover in man. Circulation 74, 805-814
20. Lange, Y., Ory, D. S., Ye, J., Lanier, M. H., Hsu, F. F. and Steck, T. L. (2008) Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductases. J. Biol. Chem. 283, 1445-1455
21. Zelcer, N., Hong, C., Boyadjian, R. and Tontonoz, P. (2009) LXR regulates cholesterol uptake through idol-dependent ubiquitination of the LDL receptor. Science 325, 100-104
22. Davidson, M. H. (2009) Novel nonstatin strategies to lower low-density lipoprotein cholesterol. Curr. Atheroscler. Rep. 11, 67-70