Molecular basis of reduced pyridoxine 5′-phosphate oxidase catalytic activity in neonatal epileptic encephalopathy disorder

Journal of Biological Chemistry

Volumn 284, Issue 45, 2009, Pages 30949-30956

  Musayev, Faik N ^a   Di Salvo, Martino L ^b   Saavedra, Mario A ^a   Contestabile, Roberto ^b   Ghatge, Mohini S ^a   Haynes, Alexina ^c   Schrich, Verne ^a   Safo, Martin K ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c VIRGINIA UNION UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AMINO ACID METABOLISM; CATALYTIC ACTIVITY; COFACTORS; HYDROGEN-BOND INTERACTIONS; MOLECULAR BASIS; OXIDASE ACTIVITY; PATHOPHYSIOLOGICAL; STRAND STRUCTURE; SUBSTRATE BINDING; VITAMIN B-6; WILD-TYPE ENZYMES;

AMINES; AMINO ACIDS; BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; CATALYST ACTIVITY; CRYSTAL STRUCTURE; ELECTROCHEMICAL SENSORS; ENZYMES; ORGANIC ACIDS; PEDIATRICS;

VITAMINS;

ARGININE; HISTIDINE; PYRIDOXAMINE PHOSPHATE OXIDASE; SERINE; SODIUM CHLORIDE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN DISEASE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME MECHANISM; ENZYME SUBSTRATE; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; HYDROGEN BOND; MISSENSE MUTATION; NEONATAL EPILEPTIC ENCEPHALOPATHY; NEWBORN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FOLDING; WILD TYPE;

BINDING SITES; CATALYSIS; CRYSTALLIZATION; EPILEPSY, BENIGN NEONATAL; FLAVIN MONONUCLEOTIDE; HUMANS; KINETICS; MOLECULAR CONFORMATION; MUTATION, MISSENSE; PROTEIN BINDING; PYRIDOXAL PHOSPHATE; PYRIDOXAMINEPHOSPHATE OXIDASE; SUBSTRATE SPECIFICITY;

EID: 71449085791     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.038372     Document Type: Article

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