High plasma free fatty acids decrease splanchnic glucose uptake in patients with non-insulin-dependent diabetes mellitus

Endocrine Journal

Volumn 45, Issue 2, 1998, Pages 165-173

  Tomita, Tadahiro ^a   Yamasaki, Yoshimitsu ^a   Kubota, Minoru ^b   Tohdo, Ryohei ^c   Katsura, Masaru ^c   Ikeda, Masahiko ^a   Nakahara, Itsuro ^a   Shiba, Yuichi ^a   Matsuhisa, Munehide ^a   Hori, Masatsugu ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b KWANSEI GAKUIN UNIVERSITY   (Japan)

^c OSAKA NATIONAL HOSPITAL   (Japan)

Author keywords

Free fatty acid; Insulin resistance; Peripheral glucose uptake; Splanchnic glucose uptake

Indexed keywords

INSULIN; ORAL ANTIDIABETIC AGENT;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TRANSPORT; HUMAN; HYPERINSULINEMIA; INSULIN RESISTANCE; INSULIN TREATMENT; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SPLANCHNIC BLOOD FLOW;

EID: 7144257855     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.45.165     Document Type: Article

References (40)

1. Lillioja S, Mott DM, Zawadzki JK, Young AA, Abbott WGH, Knowler WC, Bennett PH, Moll P, Bogardus C (1987) In vivo insulin action is a familial characteristic in nondiabetic Pima Indians. Diabetes 36: 1329-1335.
2. Eriksson J, Franssila-Kallunki A, Ekstrand A, Saloranta C, Widen E, Schalin C, Groop L (1989) Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. New Engl J Med 321: 337-343.
3. DeFronzo RA (1988) The triumvirate: β-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 37:667-687.
4. Turk D, Alzaid A, Dinne. n S, Nair KS, Rizza R (1995) The effects of non-insulin-dependent diabetes mellitus on the kinetics of onset of insulin action in hepatic and extrahepatic tissues. J Clin Invest 95: 755-762.
5. Revers RR, Fink R, Griffin J, Olefsky JM, Kolterman OG (1984) Influence of hyperglycemia on insulin's in vivo effect in type II diabetes. J Clin Invest 73: 664-672.
6. Garvey WT, Olefsky JM, Griffin J, Hamman RF, Kolterman OG (1985) The effect of insulin treatment on insulin secretion and insulin action in type II diabetes mellitus. Diabetes 34: 222-234.
7. Kawamori R, Morishima T, Ikeda M, Kubota MI, Kubota MA, Kishimoto M, Shiba Y, Matsuhisa M, Kodama M, Watarai T, Kamada T (1994) Effect of strict metabolic control on glucose handling by the liver and peripheral tissues in non-insulin-dependent diabetes mellitus. Diabetes Res Clin Pract 23: 155-161.
8. Boden G (1996) Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 45: 3-10.
9. Thiébaud D, DeFronzo RA, Jacot E, Golay A, Acheson K, Maeder E, Jéquier E, Felber JP (1982) Effect of long chain triglyceride infusion on glucose metabolism in man. Metabolism 31: 1128-1136.
10. Bonadonna RC, Zych K, Boni C, Ferrannini E, DeFronzo RA (1989) Time dependence of the interaction between lipid and glucose in humans. Am J Physiol 257: E49-E56.
11. Yki-Jarvinen H, Puhakainen I, Koivisto VA (1991) Effect of free fatty acids on glucose uptake and nonoxidative glycolysis across human forearm tissues in the basal state and during insulin stimulation. J Clin Endocrinol Metab 72: 1268-1277.
12. Boden G, Jadali F, White J, Liang Y, Mozzoli M, Chen X, Coleman E, Smith C (1991) Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. J Clin Invest 88: 960-966.
13. Boden G, Chen X, Ruiz J, White JV, Rossetti L (1994) Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93: 2438-2446.
14. Saloranta C, Koivisto V, Widen E, Falholt K, DeFronzo RA, Härkönen M, Groop L (1993) Contribution of muscle and liver to glucose-fatty acid cycle in humans. Am J Physiol 264: E599-E605.
15. Reaven GM, Hollenbeck C, Jeng CY, Wu MS, Chen YD (1988) Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes 37: 1020-1024.
16. Bevilacqua S, Buzzigoli G, Bonadonna R, Brandi LS, Oleggini M, Boni C, Geloni M, Ferrannini E (1990) Operation of Randle's cycle in patients with NIDDM. Diabetes 39: 383-389.
17. Boden G, Chen X (1995) Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes. J Clin Invest 96: 1261-1268.
18. Felig P, Wahren J, Hendler R (1978) Influence of maturity-onset diabetes on splanchnic glucose balance after oral glucose ingestion. Diabetes 27: 121-126.
19. Radziuk J, McDonald TJ, Rubenstein D, Dupre J (1978) Initial splanchnic extraction of ingested glucose in normal man. Metabolism 27: 657-669.
20. Ludvik B, Nolan JJ, Roberts A, Baloga J, Joyce M, Bell JM, OleFsky JM (1995) A noninvasive method to measure splanchnic glucose uptake after oral glucose administration. J Clin Invest 95: 2232-2238.
21. Sakura H, Kawamori R, Kubota M, Morishima T, Kamada T, Akanuma Y, Yazaki Y, Kadowaki T (1993) Glucokinase gene mutation and impaired glucose uptake by liver. Lancet 341: 1532-1533.
22. Shichiri M, Kawamori R, Yamasaki Y, Kamada T (1991) Clinical applications of a bedside-type artificial endocrine pancreas-development and application of the control algorithm. Artif Organs Today 1: 13-22.
23. DeFronzo RA, Gunnarsson R, Björkman O, Olsson M, Wahren J (1985) Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest 76: 149-155.
24. DeFronzo RA, Ferrannini E, Hendler R, Wahren J, Felig P (1978) Influence of hyperinsulinemia, hyperglycemia, and the route of glucose administration on splanchnic glucose exchange. Proc Natl Sci USA 75: 5173-5177.
25. Doberne L, Greenfield MS, Schulz B, Reaven GM (1981) Enhanced glucose utilization during prolonged glucose clamp studies. Diabetes 30: 829-835.
26. Matsuhisa M, Shi ZQ, Wan C, Lekas M, Rodgers CD, Giacca A, Kawamori R, Vranic M (1997) The effect of pioglitazone on hepatic glucose uptake measured with indirect and direct methods in alloxan-induced diabetic dogs. Diabetes 46: 224-231.
27. Waldhäusl W, Bratusch-Marrain P, Gasic S, Korn A, Nowtony P (1979) Insulin production rate following glucose ingestion estimated by splanchnic C-peptide output in normal man. Diabetologia 17: 221-227.
28. Kuyumjian J, Kalant N (1986) Absorption of an oral glucose load in dog. Harm Metabol Res 18: 587-589.
29. Gulliford MC, Bicknell EJ, Pover GG, Scarpello JH (1989) Intestinal glucose and amino acid absorption in healthy volunteers and noninsulin-dependent diabetic subjects. Am J Clin Nutr 49: 1247-1251.
30. Kingston WJ, Livingston JN, Moxley III RT (1985) Enhancement of insulin action after oral glucose ingestion. J Clin Invest 77: 1153-1162.
31. Boden G, Chen X, Rosner J, Barton M (1995) Effects of a 48-h fat infusion on insulin secretion and glucose utilization. Diabetes 44: 1239-1242.
32. Hennes MMI, Dua A, Kissebach AH (1997) Effects of free fatty acids and glucose on splanchnic insulin dynamics. Diabetes 46: 57-62.
33. Krusznyska YT, McCormack JG, McIntyre N (1991) Effects of glycogen stores and non-esterified fatty acid availability on insulin-stimulated glucose metabolism and tissue pyruvate dehydrogenase activity in the rat. Diabetologia 34: 205-211.
34. Kelley DE, Mokan M, Simoneau JA, Mandarino LJ (1993) Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest 92: 91-98.
35. Rennie MJ, Holloszy JO (1977) Inhibition of glucose uptake and glycogenolysis by availability of oleate in well-oxygenated perfused skeletal muscle. Biochem J 168: 161-170.
36. Zorzano A, Balon TW, Brady LJ, Rivera P, Garetto LP, Young JC, Goodman MN, Ruderman NB (1985) Effects of starvation and exercise on concentrations of citrate, hexose phosphates and glycogen in skeletal muscle and heart. Evidence for selective operation of the glucose-fatty acid cycle. Biochem J 232: 585-591.
37. Hue L, Maisin L, Rider MH (1988) Palmitate inhibits liver glycolysis. Biochem J 251: 541-545.
38. Tippett PS, Neet KE (1982) Specific inhibition of glucokinase by long chain acyl Coenzymes A below the critical micelle concentration. J Biol Chem 257: 12839-12845.
39. Piatti PM, Monti LD, Baruffaldi L, Magni F, Paroni R, Fermo I, Costa S, Santambrogio G, Nasser R, Marchi M, Galli-Kienle M, Pontiroli AE, Pozza G (1995) Effects of an acute increase in plasma triglyceride levels on glucose metabolism in man. Metabolism 44: 883-889.
40. Beylot M, Khalfallah Y, Riou JP, Cohen R, Normand S, Mornex R (1986) Effects of ketone bodies on basal and insulin-stimulated glucose utilization in man. J Clin Endocrinol Metab 63: 9-15.