Spread of blaCTX-M-14 is driven mainly by IncK plasmids disseminated among Escherichia coli phylogroups A, B1, and D in Spain

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 12, 2009, Pages 5204-5212

  Valverde, Aránzazu ^a,b   Cantón, Rafael ^a,b,c   Garcillán Barcia, M Pilar ^d   Novais, Ângela ^a,b   Galán, Juan Carlos ^a,b,c   Alvarado, Andrés ^d   De La Cruz, Fernando ^d   Baquero, Fernando ^a,b,c   Coque, Teresa M ^a,b,c  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

^b CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^c CSIC   (Spain)

^d University of Cantabria   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL RNA; BETA LACTAMASE; BETA LACTAMASE CTX M 14; NUCLEASE S1; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENETICS; BACTERIUM ISOLATE; CLONE; DNA HYBRIDIZATION; ESCHERICHIA COLI; GENE SEQUENCE; GENETIC VARIABILITY; HOSPITAL PATIENT; HUMAN; MAJOR CLINICAL STUDY; MULTILOCUS SEQUENCE TYPING; NUCLEOTIDE SEQUENCE; PHYLOGENY; PLASMID; POLYMERASE CHAIN REACTION; POPULATION GENETICS; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RNA INTERFERENCE; SPAIN; URINARY TRACT INFECTION;

AMINO ACID SEQUENCE; BETA-LACTAMASES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HUMANS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; PHYLOGENY; PLASMIDS; POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; SPAIN;

EID: 71249128722     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01706-08     Document Type: Article

References (58)

1. Alvarado, A., M. P. Garcillán-Barcia, and F. de la Cruz. 2008. A PCR-based method for classification of conjugative plasmids based on relaxase sequences, p. 134. In Proceedings of the International Plasmid Biology Conference. International Plasmid Biology Society, Gdansk, Poland.
2. a.Araki, Y., M. Inoue, and S. Mitsuhashi. 1983. Incompatibility group K plasmids in bacteria isolated from a urinary tract infection. Microbiol. Immunol. 27:1-5.
3. CTX-M-14 gene. Antimicrob. Agents Chemother. 51:3017-3019.
4. Baquero, F. 2004. From pieces to patterns: evolutionary engineering in bacterial pathogens. Nat. Rev. Microbiol. 2:510-518.
5. CTX-Ms. Emerg. Infect. Dis. 14:423-428.
6. Bou, G., M. Cartelle, M. Tomas, D. Canle, F. Molina, R. Moure, J. M. Eiros, and A. Guerrero. 2002. Identification and broad dissemination of the CTX-M-14 beta-lactamase in different Escherichia coli strains in the northwest area of Spain. J. Clin. Microbiol. 40:4030-4036.
7. Cagnacci, S., L. Gualco, E. Debbia, G. C. Schito, and A. Marchese. 2008. European emergence of ciprofloxacin-resistant Escherichia coli clonal groups O25:H4-ST 131 and O15:K52:H1 causing community-acquired uncomplicated cystitis. J. Clin. Microbiol. 46:2605-2612.
8. Cantón, R., and T. M. Coque. 2006. The CTX-M beta-lactamase pandemic. Curr. Opin. Microbiol. 9:466-475.
9. Carattoli, A., A. Bertini, L. Villa, V. Falbo, K. L. Hopkins, and E. J. Threlfall. 2005. Identification of plasmids by PCR-based replicon typing. J. Microbiol. Methods 63:219-228. (Pubitemid 41597366)
10. CTX-M among Enterobacteriaceae in U.S. medical centers: molecular evaluation from the MYSTIC Program (2007). Microb. Drug Resist. 14:211-216.
11. Clermont, O., S. Bonacorsi, and E. Bingen. 2000. Rapid and simple determination of the Escherichia coli phylogenetic group. Appl. Environ. Microbiol. 66:4555-4558.
12. Clinical and Laboratory Standards Institute. 2006. Performance standards for antimicrobial susceptibility testing. Clinical and Laboratory Standards Institute, Wayne, PA.
13. Coque, T. M., F. Baquero, and R. Cantón. 2008. Increasing prevalence of ESBL-producing Enterobacteriaceae in Europe. Euro. Surveill. 13:19044. (Erratum, 13:19051.)
14. Couturier M., F. Bex, P. L. Bergquist, and W. K. Maas. 1988. Identification and classification of bacterial plasmids. Microbiol. Rev. 52:375-395.
15. del Solar, G., R. Giraldo, M. J. Ruiz-Echevarría, M. Espinosa, and R. Díaz-Orejas. 1998. Replication and control of circular bacterial plasmids. Microbiol. Mol. Biol. Rev. 62:434-464.
16. ESBL and surrounding genes in Spanish clinical isolates of Escherichia coli and Klebsiella pneumoniae. J. Antimicrob. Chemother. 63:60-66.
17. Dudley, E. G., C. Abe, J. M. Ghigo, P. Latour-Lambert, J. C. Hormazabal, and J. P. Nataro. 2006. An IncI1 plasmid contributes to the adherence of the atypical enteroaggregative Escherichia coli strain C1096 to cultured cells and abiotic surfaces. Infect. Immun. 74:2102-2114.
18. CTX-M genes. J. Antimicrob. Chemother. 57:14-23.
19. Escobar-Páramo, P., O. Clermont, A. B. Blanc-Potard, H. Bui, C. Le Bouguenec, and E. Denamur. 2004. A specific genetic background is required for acquisition and expression of virulence factors in Escherichia coli. Mol. Biol. Evol. 21:1085-1094. (Pubitemid 38658217)
20. Garcillán-Barcia, M. P., M. V. Francia, and F. de la Cruz. 2009. The diversity of conjugative relaxases and its application in plasmid classification. FEMS Microbiol. Rev. 33:657-687.
21. Gordon, D. M., O. Clermont, H. Tolley, and E. Denamur. 2008. Assigning Escherichia coli strains to phylogenetic groups: multi-locus sequence typing versus the PCR triplex method. Environ. Microbiol. 10:2484-2496.
22. - R factors giving chloramphenicol resistance. Nature 234:220-221.
23. Hernández, J. R., L. Martínez-Martínez, R. Cantón, T. M. Coque, and A. Pascual. 2005. Nationwide study of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases in Spain. Antimicrob. Agents Chemother. 49:2122-2125.
24. Ho, P. L., W. W. Poon, S. L. Loke, M. S. Leung, K. H. Chow, R. C. Wong, K. S. Yip, E. L. Lai, and K. W. Tsang. 2007. Community emergence of CTX-M type extended-spectrum beta-lactamases among urinary Escherichia coli from women. J. Antimicrob. Chemother. 60:140-144.
25. Jaureguy, F., L. Landraud, V. Passet, L. Diancourt, E. Frapy, G. Guigon, E. Carbonnelle, O. Lortholary, O. Clermont, E. Denamur, B. Picard, X. Nassif, and S. Brisse. 2009. Phylogenetic and genomic diversity of human bacteremic Escherichia coli strains. BMC Genomics 9:560.
26. Kiratisin, P., A. Apisarnthanarak, C. Laesripa, and P. Saifon. 2008. Molecular characterization and epidemiology of extended-spectrumbeta- lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. Antimicrob. Agents Chemother. 52:2818-2824.
27. Ko, K. S., M. Y. Lee, J. H. Song, H. Lee, D. S. Jung, S. I. Jung, S. W. Kim, H. H. Chang, J. S. Yeom, Y. S. Kim, H. K. Ki, D. R. Chung, K. T. Kwon, K. R. Peck, and N. Y. Lee. 2008. Prevalence and characterization of extended-spectrum beta-lactamase-producing Enterobacteriaceae isolated in Korean hospitals. Diagn. Microbiol. Infect. Dis. 61:453-459.
28. Kumar, S., K. Tamura, and M. Nei. 2004. MEGA3: integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief. Bioinform. 5:150-163.
29. Lau, S. H., S. Reddy, J. Cheesbrough, F. J. Bolton, G. Willshaw, T. Cheasty, A. J. Fox, and M. Upton. 2008. Major uropathogenic Escherichia coli strain isolated in the northwest of England identified by multilocus sequence typing. J. Clin. Microbiol. 46:1076-1080.
30. Leflon-Guibout, V., J. Blanco, K. Amaqdouf, A. Mora, L. Guize, and M. H. Nicolas-Chanoine. 2008. Absence of CTX-M enzymes but high prevalence of clones, including clone ST131, among fecal Escherichia coli isolates from healthy subjects living in the area of Paris, France. J. Clin. Microbiol. 46: 3900-3905.
31. Lescat M., A. Calteau, C. Hoede, V. Barbe, M. Touchon, E. Rocha, O. Tenaillon, C. Médigue, J. R. Johnson, and E. Denamur. 2009. A module located at a chromosomal integration hot spot is responsible for the multidrug resistance of a reference strain from Escherichia coli clonal group A. Antimicrob. Agents Chemother. 53:2283-2288.
32. Liebana, E., M. Batchelor, K. L. Hopkins, F. A. Clifton-Hadley, C. J. Teale, A. Foster, L. Barker, E. J. Threlfall, and R. H. Davies. 2006. Longitudinal farm study of extended-spectrum beta-lactamase-mediated resistance. J. Clin. Microbiol. 44:1630-1634.
33. Liu, W., L. Chen, H. Li, H. Duan, Y. Zhang, X. Liang, X. Li, M. Zou, L. Xu, and P. M. Hawkey. 2009. Novel CTX-M β-lactamase genotype distribution and spread into multiple species of Enterobacteriaceae in Changsha, southern China. J. Antimicrob. Chemother. 63:895-900.
34. Ma, L., C. J. Lin, J. H. Chen, C. P. Fung, F. Y. Chang, Y. K. Lai, J. C. Lin, L. K. Siu, and the Taiwan Surveillance of Antimicrobial Resistance Project. 2009. Widespread dissemination of aminoglycoside resistance genes armA and rmtB in Klebsiella pneumoniae isolates in Taiwan producing CTX-M-type extended-spectrum beta-lactamases. Antimicrob. Agents Chemother. 53:104-111.
35. Marcade, G., C. Deschamps, A. Boyd, V. Gautier, B. Picard, C. Branger, E. Denamur, and G. Arlet. 2009. Replicon typing of plasmids in Escherichia coli producing extended-spectrum beta-lactamases. J. Antimicrob. Chemother. 63:67-71.
36. Martinez, J. L., and F. Baquero. 2002. Interactions among strategies associated with bacterial infection: pathogenicity, epidemicity, and antibiotic resistance. Clin. Microbiol. Rev. 15:647-679.
37. Mendonca, N., J. Leitao, V. Manageiro, E. Ferreira, and M. Canica. 2007. Spread of extended-spectrum beta-lactamase CTX-M-producing Escherichia coli clinical isolates in community and nosocomial environments in Portugal. Antimicrob. Agents Chemother. 51:1946-1955.
38. Minarini, L. A., I. L. Camargo, A. Pitondo-Silva, and A. L. Darini. 2007. Multilocus sequence typing of uropathogenic ESBL-producing Escherichia coli isolated in a Brazilian community. Curr. Microbiol. 55:524-529.
39. Mulvey, M. R., E. Bryce, D. Boyd, M. Ofner-Agostini, S. Christianson, A. E. Simor, and S. Paton. 2004. Ambler class A extended-spectrum beta-lactamase- producing Escherichia coli and Klebsiella spp. in Canadian hospitals. Antimicrob. Agents Chemother. 48:1204-1214.
40. Navarro, F., R. J. Mesa, E. Miro, L. Gomez, B. Mirelis, and P. Coll. 2007. Evidence for convergent evolution of CTX-M-14 ESBL in Escherichia coli and its prevalence. FEMS Microbiol. Lett. 273:120-123.
41. Novais, A., R. Canton, R. Moreira, L. Peixe, F. Baquero, and T. M. Coque. 2007. Emergence and dissemination of Enterobacteriaceae isolates producing CTX-M-1-like enzymes in Spain are associated with IncFII (CTX-M-15) and broad-host-range (CTX-M-1, -3, and -32) plasmids. Antimicrob. Agents Chemother. 51:796-799.
42. CTX-M-9 are linked to class 1 integrons containing CR1 associated with defective transposon derivatives from Tn402 located in early antibiotic resistance plasmids of IncHI2, IncP1-alpha, and IncFI groups. Antimicrob. Agents Chemother. 50:2741-2750.
43. Osborn, A. M., F. M. da Silva Tatley, L. M. Steyn, R. W. Pickup, and J. R. Saunders. 2000. Mosaic plasmids and mosaic replicons: evolutionary lessons from the analysis of genetic diversity in IncFII-related replicons. Microbiology 146:2267-2275.
44. Oshima, K., H. Toh, Y. Ogura, H. Sasamoto, H. Morita, S. H. Park, T. Ooka, S. Iyoda, T. D. Taylor, T. Hayashi, K. Itoh, and M. Hattori. 2008. Complete genome sequence and comparative analysis of the wild-type commensal Escherichia coli strain SE11 isolated from a healthy adult. DNA Res. 15:375-386.
45. Oteo, J., K. Diestra, C. Juan, V. Bautista, A. Novais, M. Pérez-Vázquez, B. Moyá, E. Miró, T. M. Coque, A. Oliver, R. Cantón, F. Navarro, and J. Campos. Extended-spectrum beta-lactamase-producing Escherichia coli in Spain belong to a large variety of multilocus sequence typing types, including ST10 complex/A, ST23 complex/A and ST131/B2. Int. J. Antimicrob. Agents 34:173-176.
46. Pai, H., E. H. Choi, H. J. Lee, J. Y. Hong, and G. A. Jacoby. 2001. Identification of CTX-M-14 extended-spectrum beta-lactamase in clinical isolates of Shigella sonnei, Escherichia coli, and Klebsiella pneumoniae in Korea. J. Clin. Microbiol. 39:3747-3749.
47. Pitout, J. D., D. B. Gregson, D. L. Church, S. Elsayed, and K. B. Laupland. 2005. Community-wide outbreaks of clonally related CTX-M-14 beta-lactamase- producing Escherichia coli strains in the Calgary health region. J. Clin. Microbiol. 43:2844-2849.
48. Pitout, J. D., K. B. Laupland, D. L. Church, M. L. Menard, and J. R. Johnson. 2005. Virulence factors of Escherichia coli isolates that produce CTX-M-type extended-spectrum beta-lactamases. Antimicrob. Agents Chemother. 49:4667-4670.
49. Rodríguez-Baño, J., M. D. Navarro, L. Romero, L. Martinez-Martinez, M. A. Muniain, E. J. Perea, R. Perez-Cano, and A. Pascual. 2004. Epidemiology and clinical features of infections caused by extended-spectrum beta-lactamase-producing Escherichia coli in nonhospitalized patients. J. Clin. Microbiol. 42:1089-1094.
50. Suzuki, S., N. Shibata, K. Yamane, J.-I. Wachino, K. Ito, and Y. Arakawa. 2009. Change in the prevalence of extended-spectrum-β-lactamase-producing Escherichia coli in Japan by clonal spread. J. Antimicrob. Chemother. 63:72-79.
51. Tartof, S. Y., O. D. Solberg, A. R. Manges, and L. W. Riley. 2005. Analysis of a uropathogenic Escherichia coli clonal group by multilocus sequence typing. J. Clin. Microbiol. 43:5860-5864.
52. Tschäpe, H., and E. Tietze. 1980. Genetic and molecular characterization of R plasmids incompatible with R387 (IncK). J. Gen. Microbiol. 118:515-521. (Pubitemid 10013009)
53. Turner, S. M., R. R. Chaudhuri, Z. D. Jiang, H. DuPont, C. Gyles, C. W. Penn, M. J. Pallen, and I. R. Henderson. 2006. Phylogenetic comparisons reveal multiple acquisitions of the toxin genes by enterotoxigenic Escherichia coli strains of different evolutionary lineages. J. Clin. Microbiol. 44:4528-4536.
54. Valverde, A., T. M. Coque, M. P. Sánchez-Moreno, A. Rollán, F. Baquero, and R. Cantón. 2004. Dramatic increase in prevalence of fecal carriage of extended-spectrum beta-lactamase-producing Enterobacteriaceae during nonoutbreak situations in Spain. J. Clin. Microbiol. 42:4769-4775.
55. Valverde, A., F. Grill, T. M. Coque, V. Pintado, F. Baquero, R. Cantón, and J. Cobo. 2008. High rate of intestinal colonization with extended-spectrum-beta- lactamase-producing organisms in household contacts of infected community patients. J. Clin. Microbiol. 46:2796-2799.
56. a.Valverde, A., R. Cantón, P. Hawkey, J. D. Pitout, P. Nordmann, L. Peixe, F. Baguero, and T. M. Coque. 2009. International dissemination of extended-spectrum beta-lactamase CTX-M-14 in Enterobacteriaceae isolates is mainly associated with the spread of IncK and IncF plasmids. In 19th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). Clin. Microbiol. Infect. 15(Suppl.):S67, O305.
57. Wirth, T., D. Falush, R. Lan, F. Colles, P. Mensa, L. H. Wieler, H. Karch, P. R. Reeves, M. C. Maiden, H. Ochman, and M. Achtman. 2006. Sex and virulence in Escherichia coli: an evolutionary perspective. Mol. Microbiol. 60:1136-1151.
58. Woodford, N., M. E. Ward, M. E. Kaufmann, J. Turton, E. J. Fagan, D. James, A. P. Johnson, R. Pike, M. Warner, T. Cheasty, A. Pearson, S. Harry, J. B. Leach, A. Loughrey, J. A. Lowes, R. E. Warren, and D. M. Livermore. 2004. Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum beta-lactamases in the UK. J. Antimicrob. Chemother. 54:735-743.