High doses of inhaled corticosteroids during the first trimester of pregnancy and congenital malformations

Journal of Allergy and Clinical Immunology

Volumn 124, Issue 6, 2009, Pages

  Blais, Lucie ^a,b,c   Beauchesne, Marie France ^a,b,c   Lemière, Catherine ^a,b   Elftouh, Naoual ^b  

^a UNIVERSITÉ DE MONTRÉAL   (Canada)

^b HÔPITAL DU SACRÉ COEUR DE MONTRÉAL   (Canada)

^c NONE

Author keywords

Asthma; cohort study; congenital malformations; inhaled corticosteroids; pregnancy

Indexed keywords

BECLOMETASONE DIPROPIONATE; BUDESONIDE; CORTICOSTEROID; FLUNISOLIDE; FLUTICASONE PROPIONATE; TRIAMCINOLONE ACETONIDE;

ARTICLE; ASTHMA; CANADA; COHORT ANALYSIS; CONGENITAL MALFORMATION; DOSE RESPONSE; DRUG MEGADOSE; DRUG SAFETY; FIRST TRIMESTER PREGNANCY; HUMAN; MAJOR CLINICAL STUDY; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RISK ASSESSMENT;

EID: 71249084655     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2009.09.025     Document Type: Article

References (43)

1. NAEPP expert panel report. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. J Allergy Clin Immunol 115 (2005) 34-46
2. Olesen C., Steffensen F.H., Nielsen G.L., de Jong-van den Berg O.J., and Sorensen H.T. Drug use in first pregnancy and lactation: a population-based survey among Danish women. The EUROMAP group. Eur J Clin Pharmacol 55 (1999) 139-144
3. Breton M.C., Martel M.J., Vilain A., and Blais L. Inhaled corticosteroids during pregnancy: a review of methodologic issues. Respir Med 102 (2008) 862-875
4. Alexander S., Dodds L., and Armson B.A. Perinatal outcomes in women with asthma during pregnancy. Obstet Gynecol 92 (1998) 435-440
5. Bakhireva L.N., Jones K.L., Schatz M., Johnson D., and Chambers C.D. Asthma medication use in pregnancy and fetal growth. J Allergy Clin Immunol 116 (2005) 503-509
6. Blais L., Beauchesne M.F., Rey E., Malo J.L., and Forget A. Use of inhaled corticosteroids during the first trimester of pregnancy and the risk of congenital malformations among women with asthma. Thorax 62 (2007) 320-328
7. Dombrowski M.P., Brown C.L., and Berry S.M. Preliminary experience with triamcinolone acetonide during pregnancy. J Matern Fetal Med 5 (1996) 310-313
8. Dombrowski M.P., Schatz M., Wise R., Thom E.A., Landon M., Mabie W., et al. Randomized trial of inhaled beclomethasone dipropionate versus theophylline for moderate asthma during pregnancy. Am J Obstet Gynecol 190 (2004) 737-744
9. Kallen B., Rydhstroem H., and Aberg A. Congenital malformations after the use of inhaled budesonide in early pregnancy. Obstet Gynecol 93 (1999) 392-395
10. Kallen B.A., and Otterblad O.P. Maternal drug use in early pregnancy and infant cardiovascular defect. Reprod Toxicol 17 (2003) 255-261
11. Namazy J., Schatz M., Long L., Lipkowitz M., Lillie M.A., Voss M., et al. Use of inhaled steroids by pregnant asthmatic women does not reduce intrauterine growth. J Allergy Clin Immunol 113 (2004) 427-432
12. Olesen C., Thrane N., Nielsen G.L., Sorensen H.T., and Olsen J. A population-based prescription study of asthma drugs during pregnancy: changing the intensity of asthma therapy and perinatal outcomes. Respiration 68 (2001) 256-261
13. Perlow J.H., Montgomery D., Morgan M.A., Towers C.V., and Porto M. Severity of asthma and perinatal outcome. Am J Obstet Gynecol 167 4 pt 1 (1992) 963-967
14. Schatz M., Zeiger R.S., Harden K., Hoffman C.C., Chilingar L., and Petitti D. The safety of asthma and allergy medications during pregnancy. J Allergy Clin Immunol 100 (1997) 301-306
15. Schatz M., Dombrowski M.P., Wise R., Momirova V., Landon M., Mabie W., et al. The relationship of asthma medication use to perinatal outcomes. J Allergy Clin Immunol 113 (2004) 1040-1045
16. Silverman M., Sheffer A., Diaz P.V., Lindmark B., Radner F., Broddene M., et al. Outcome of pregnancy in a randomized controlled study of patients with asthma exposed to budesonide. Ann Allergy Asthma Immunol 95 (2005) 566-570
17. Kallen B., and Otterblad O.P. Use of anti-asthmatic drugs during pregnancy, 3: congenital malformations in the infants. Eur J Clin Pharmacol 63 (2007) 383-388
18. Éricson A, Kallen B. Use of drugs during pregnancy-unique Swedish registration method that can be improved. Information from the Swedish Medical Products Agency, editor. 1-8. 1999.
19. Régie de l'assurance maladie du Québec. Statistiques annuelles. 1-1-2006. Available at: http://www.ramq.gouv.qc.ca. Accessed October 2009.
20. Blais L., and Beauchesne M.F. Use of inhaled corticosteroids following discharge from an emergency department for an acute exacerbation of asthma. Thorax 59 (2004) 943-947
21. Marceau C., Lemiere C., Berbiche D., Perreault S., and Blais L. Persistence, adherence, and effectiveness of combination therapy among adult patients with asthma. J Allergy Clin Immunol 118 (2006) 574-581
22. Martel M.J., Rey E., Beauchesne M.F., Perreault S., Lefebvre G., Forget A., et al. Use of inhaled corticosteroids during pregnancy and risk of pregnancy induced hypertension: nested case-control study. BMJ 330 (2005) 230
23. Martel M.J., Rey E., Beauchesne M.F., Perreault S., Forget A., Maghni K., et al. Use of short-acting beta2-agonists during pregnancy and the risk of pregnancy-induced hypertension. J Allergy Clin Immunol 119 (2007) 576-582
24. Blais L., Lemiere C., Menzies D., and Berbiche D. Validity of asthma diagnoses recorded in the Medical Services database of Quebec. Pharmacoepidemiol Drug Saf 15 (2006) 245-252
25. Tamblyn R., Lavoie G., Petrella L., and Monette J. The use of prescription claims databases in pharmacoepidemiological research: the accuracy and comprehensiveness of the prescription claims database in Quebec. J Clin Epidemiol 48 (1995) 999-1009
26. Vilain A., Otis S., Forget A., and Blais L. Agreement between administrative databases and medical charts for pregnancy-related variables among asthmatic women. Pharmacoepidemiol Drug Saf 17 (2008) 345-353
27. Heinonen O., Slone D., and Shapiro S. Birth defects and drugs in pregnancy (1977), Publishing Sciences Group, Inc, Littleton
28. Lemiere C., Bai T., Balter M., Bayliff C., Becker A., Boulet L.P., et al. Adult Asthma Consensus Guidelines Update 2003. Can Respir J 11 suppl A (2004) 9A-18A
29. Koren G., Pastuszak A., and Ito S. Drugs in pregnancy. N Engl J Med 338 (1998) 1128-1137
30. Firoozi F., Lemiere C., Beauchesne M.F., Forget A., and Blais L. Development and validation of database indexes of asthma severity and control. Thorax 62 (2007) 581-587
31. Zeger S.L., Liang K.Y., and Albert P.S. Models for longitudinal data: a generalized estimating equation approach. Biometrics 44 (1988) 1049-1060
32. Greenland S. Modeling and variable selection in epidemiologic analysis. Am J Public Health 79 (1989) 340-349
33. National Institute of Health. Expert Panel Report 3: guidelines for the diagnosis and management of asthma (2007), National Asthma Education and Prevention Program, National Heart, Lung, and Blood Institute (NHLBI); US Department of Health and Human Services NIH publication number 08-5846
34. Carmichael S.L., and Shaw G.M. Maternal corticosteroid use and risk of selected congenital anomalies. Am J Med Genet 86 (1999) 242-244
35. Park-Wyllie L., Mazzotta P., Pastuszak A., Moretti M.E., Beique L., Hunnisett L., et al. Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratology 62 (2000) 385-392
36. Rodriguez-Pinilla E., and Martinez-Frias M.L. Corticosteroids during pregnancy and oral clefts: a case-control study. Teratology 58 (1998) 2-5
37. Bateman E.D., Boushey H.A., Bousquet J., Busse W.W., Clark T.J., Pauwels R.A., et al. Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study. Am J Respir Crit Care Med 170 (2004) 836-844
38. Rabe K.F., Atienza T., Magyar P., Larsson P., Jorup C., and Lalloo U.G. Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: a randomised controlled, double-blind study. Lancet 368 (2006) 744-753
39. Blais L., and Forget A. Asthma exacerbations during the first trimester of pregnancy and the risk of congenital malformations among asthmatic women. J Allergy Clin Immunol 121 (2008) 1379-1384
40. Braems G. Fetal hypoxemia on a molecular level: adaptive changes in the hypothalamic-pituitary-adrenal (HPA) axis and the lungs. Eur J Obstet Gynecol Reprod Biol 110 suppl 1 (2003) S63-S69
41. Cousins L. Fetal oxygenation, assessment of fetal well-being, and obstetric management of the pregnant patient with asthma. J Allergy Clin Immunol 103 2 pt 2 (1999) S343-S349
42. Guy E.S., Kirumaki A., and Hanania N.A. Acute asthma in pregnancy. Crit Care Clin 20 (2004) 731-745 x
43. Danielsson B.R., Skold A.C., Johansson A., Dillner B., and Blomgren B. Teratogenicity by the hERG potassium channel blocking drug almokalant: use of hypoxia marker gives evidence for a hypoxia-related mechanism mediated via embryonic arrhythmia. Toxicol Appl Pharmacol 193 (2003) 168-176