Fetal hypoxemia on a molecular level: Adaptive changes in the hypothalamic-pituitary-adrenal (HPA) axis and the lungs

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 110, Issue SUPPL., 2003, Pages

  Braems, Geert ^a,b  

^a Zentrum f Frauenheilkunde/G   (Germany)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Fexus; Hypothalamic pituitary adrenal axis; Hypoxemia; Hypoxia; Intra uterine; Lung

Indexed keywords

ANDROSTENEDIONE; CORTICOTROPIN; CORTICOTROPIN RECEPTOR; HYDROCORTISONE; MESSENGER RNA; PROOPIOMELANOCORTIN; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN C; SURFACTANT PROTEIN A;

ADRENAL GLAND; ANDROSTENEDIONE BLOOD LEVEL; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL PH; CONFERENCE PAPER; CORTICOTROPIN BLOOD LEVEL; ENZYME ACTIVITY; FETUS DEVELOPMENT; FETUS HYPOXIA; FETUS LUNG; FETUS LUNG MATURATION; GESTATIONAL AGE; HORMONE ACTION; HORMONE SYNTHESIS; HYDROCORTISONE BLOOD LEVEL; HYPOPHYSIS; HYPOPHYSIS INTERMEDIATE LOBE; HYPOPHYSIS PARS DISTALIS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; SHEEP; STEROIDOGENESIS; UPREGULATION;

EID: 0042836797     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-2115(03)00174-X     Document Type: Conference Paper

References (6)

1. Barker DJP, 1994. Mothers, babies and disease in later life. BMJ Publishing Group.
2. Braems G.A., Matthews S.G., Challis J.R.G. Differential regulation of pro-opiomelanocortin messenger ribonucleic acid in the pars distalis and pars intermedia of the pituitary gland after prolonged hypoxemia in fetal sheep. Endocrinology. 137:1996;2731-2738.
3. Braems G.A., Han V.K.M., Challis J.R.G. Gestational age-dependent changes in the levels of mRNAs encoding cortisol biosynthetic enzymes and IGF-II in the adrenal gland of fetal sheep during prolonged hypoxemia. J. Endocrinol. 159:1998;257-264.
4. Braems G.A., Yao L.J., Inchley K., Possmayer F. Ovine surfactant protein cDNAs: use in studies op fetal lung growth and maturation after prolonged hypoxemia. Am. J. Physiol. (Lung Cell Mol Physiol). 278:2001;754-764.
5. Fraser M., Matthews S.G., Braems G., Jeffray T., Challis J.R.G. Developmental regulation of preproenkephalin (PENK) gene expression in the adrenal gland of the ovine fetus and newborn lamb: effects of hypoxemia and exogenous cortisol infusion. J. Endocrinol. 155:1997;143-149.
6. Fraser M., Braems G.A., Challis J.R.G. Developmental regulation of corticotrophin receptor (ACTH-R) gene expression in the adrenal gland of the ovine fetus and newborn lamb: effects of hypoxia during late pregnancy. J. Endocrinol. 169:2001;1-10.