Assessment of a mechano-regulation theory of skeletal tissue differentiation in an in vivo model of mechanically induced cartilage formation

Biomechanics and Modeling in Mechanobiology

Volumn 8, Issue 6, 2009, Pages 447-455

  Hayward, Lauren Nicole Miller ^a   Morgan, Elise F ^a  

^a Boston University   (United States)

Author keywords

Bending motion; Finite element analysis; Mechanical stimulation; Mechanobiology; Mesenchymal stem cell; Pseudarthrosis

Indexed keywords

BENDING MOTION; FINITE ELEMENT ANALYSIS; MECHANICAL STIMULATION; MECHANO-BIOLOGY; MESENCHYMAL STEM CELL;

BONE; CARTILAGE; CELL CULTURE; CELLS; COMPUTERIZED TOMOGRAPHY; FINITE ELEMENT METHOD; FLOW OF FLUIDS; FORECASTING; HISTOLOGY; LAWS AND LEGISLATION; LIGAMENTS; THREE DIMENSIONAL; TOMOGRAPHY;

SHEAR STRAIN;

ANIMAL; ARTHRITIS; ARTICLE; BIOMECHANICS; BONE; CARTILAGE; CELL DIFFERENTIATION; COMPUTER ASSISTED TOMOGRAPHY; CYTOLOGY; FEMUR FRACTURE; FINITE ELEMENT ANALYSIS; MECHANICAL STRESS; MESENCHYMAL STROMA CELL; METABOLISM; METHODOLOGY; MOTION; PATHOLOGY; PATHOPHYSIOLOGY; RAT; SHEAR STRENGTH; STATISTICAL MODEL; THREE DIMENSIONAL IMAGING;

ANIMALS; ARTHRITIS; BIOMECHANICS; BONE AND BONES; CARTILAGE; CELL DIFFERENTIATION; FEMORAL FRACTURES; FINITE ELEMENT ANALYSIS; IMAGING, THREE-DIMENSIONAL; MESENCHYMAL STROMAL CELLS; MODELS, STATISTICAL; MOTION; RATS; SHEAR STRENGTH; STRESS, MECHANICAL; TOMOGRAPHY, X-RAY COMPUTED;

EID: 71249083983     PISSN: 16177959     EISSN: 16822978     Source Type: Journal    
DOI: 10.1007/s10237-009-0148-3     Document Type: Article

References (32)

1. P Angele D Schumann M Angele B Kinner C Englert R Hente B Fuchtmeier M Nerlich C Neumann R Kujat 2004 Cyclic, mechanical compression enhances chondrogenesis of mesenchymal progenitor cells in tissue engineering scaffolds Biorheology 41 3-4 335 346
2. A Bailon-Plaza MC Vander Meulen 2003 Beneficial effects of moderate, early loading and adverse effects of delayed or excessive loading on bone healing J Biomech 36 1069 1077 10.1016/S0021-9290(03)00117-9 10.1016/S0021-9290(03)00117-9 (Pubitemid 36794102)
3. PR Blenman DR Carter GS Beaupre 1989 Role of mechanical loading in the progressive ossification of a fracture callus J Orthop Res 7 3 398 407 10.1002/jor.1100070312 10.1002/jor.1100070312 (Pubitemid 19132858)
4. DP Byrne D Lacroix JA Planell DJ Kelly PJ Prendergast 2007 Simulation of tissue differentiation in a scaffold as a function of porosity, Young's modulus and dissolution rate: application of mechanobiological models in tissue engineering Biomaterials 28 36 5544 5554 10.1016/j.biomaterials.2007.09.003 10.1016/j.biomaterials.2007.09.003 (Pubitemid 47599648)
5. DR Carter GS Beaupre NJ Giori JA Helms 1998 Mechanobiology of skeletal regeneration Clin Orthop Relat Res 355 Suppl S41 S55 10.1097/00003086-199810001- 00006 10.1097/00003086-199810001-00006
6. DR Carter PR Blenman GS Beaupre 1988 Correlations between mechanical stress history and tissue differentiation in initial fracture healing J Orthop Res 6 5 736 748 10.1002/jor.1100060517 10.1002/jor.1100060517 (Pubitemid 18218538)
7. LE Claes CA Heigele 1999 Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing J Biomech 32 3 255 266 10.1016/S0021-9290(98)00153-5 10.1016/S0021-9290(98)00153-5 (Pubitemid 29125449)
8. DM Cullinane A Fredrick SR Eisenberg D Pacicca MV Elman C Lee K Salisbury LC Gerstenfeld TA Einhorn 2002 Induction of a neoarthrosis by precisely controlled motion in an experimental mid-femoral defect J Orthop Res 20 3 579 586 10.1016/S0736-0266(01)00131-0 10.1016/S0736-0266(01)00131-0 (Pubitemid 34461018)
9. DM Cullinane KT Salisbury Y Alkhiary S Eisenberg L Gerstenfeld TA Einhorn 2003 Effects of the local mechanical environment on vertebrate tissue differentiation during repair: does repair recapitulate development? J Exp Biol 206 Pt 14 2459 2471 10.1242/jeb.00453 10.1242/jeb.00453 (Pubitemid 36914465)
10. T Davisson S Kunig A Chen R Sah A Ratcliffe 2002 Static dynamic compression modulate matrix metabolism in tissue engineered cartilage J Orthop Res 20 842 848 10.1016/S0736-0266(01)00160-7 10.1016/S0736-0266(01)00160-7 (Pubitemid 34823007)
11. T Davisson RL Sah A Ratcliffe 2002 Perfusion increases cell content and matrix synthesis in chondrocyte three-dimensional cultures Tissue Eng 8 5 807 816 10.1089/10763270260424169 10.1089/10763270260424169 (Pubitemid 35239758)
12. DR Epari WR Taylor M Heller GN Duda 2006 Mechanical conditions in the initial phase of bone healing Clin Biomech (Bristol, Avon) 21 646 655 10.1016/j.clinbiomech.2006.01.003 10.1016/j.clinbiomech.2006.01.003 (Pubitemid 43816744)
13. LC Gerstenfeld YM Alkhiary EA Krall FH Nicholls SN Stapleton JL Fitch M Bauer R Kayal DT Graves KJ Jepsen, et al. 2006 Three-dimensional reconstruction of fracture callus morphogenesis J Histochem Cytochem 54 11 1215 1228 10.1369/jhc.6A6959.2006 10.1369/jhc.6A6959.2006 (Pubitemid 44623342)
14. AE Goodship J Kenwright 1985 The influence of induced micromovement upon the healing of experimental tibial fractures J Bone Joint Surg Br 67 4 650 655
15. R Hente B Fuchtmeier U Schlegel A Ernstberger SM Perren 2004 The influence of cyclic compression and distraction on the healing of experimental tibial fractures J Orthop Res 22 709 715 10.1016/j.orthres.2003.11.007 10.1016/j.orthres.2003.11.007 (Pubitemid 38756248)
16. CT Hung RL Mauck CC Wang EG Lima GA Ateshian 2004 A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading Ann Biomed Eng 32 1 35 49 10.1023/B:ABME.0000007789.99565. 42 10.1023/B:ABME.0000007789.99565.42
17. H Isaksson O Comas CC van Donkelaar J Mediavilla W Wilson R Huiskes K Ito 2007 Bone regeneration during distraction osteogenesis: mechano-regulation by shear strain and fluid velocity J Biomech 40 9 2002 2011 10.1016/j.jbiomech. 2006.09.028 10.1016/j.jbiomech.2006.09.028 (Pubitemid 46843004)
18. H Isaksson CC van Donkelaar R Huiskes K Ito 2006 Corroboration of mechanoregulatory algorithms for tissue differentiation during fracture healing: Comparison with in vivo results J Orthop Res 24 5 898 907 10.1002/jor.20118 10.1002/jor.20118 (Pubitemid 43804924)
19. H Isaksson W Wilson CC van Donkelaar R Huiskes K Ito 2006 Comparison of biophysical stimuli for mechano-regulation of tissue differentiation during fracture healing J Biomech 39 8 1507 1516 10.1016/j.jbiomech.2005.01.037 10.1016/j.jbiomech.2005.01.037
20. DJ Kelly PJ Prendergast 2005 Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects J Biomech 38 7 1413 1422 10.1016/j.jbiomech.2004.06.026 10.1016/j.jbiomech.2004.06.026 (Pubitemid 40744898)
21. DJ Kelly PJ Prendergast 2006 Prediction of the optimal mechanical properties for a scaffold used in osteochondral defect repair Tissue Eng 12 9 2509 2519 10.1089/ten.2006.12.2509 10.1089/ten.2006.12.2509 (Pubitemid 46141274)
22. M Knippenberg MN Helder BZ Doulabi CM Semeins PIJM Wuisman J Klein-Nulend 2005 Adipose tissue-derived mesenchymal stem cells acquire bone cell-like responsiveness to fluid shear stress on osteogenic stimulation Tissue Eng 11 11/12 1780 1788 10.1089/ten.2005.11.1780 10.1089/ten.2005.11.1780 (Pubitemid 43120189)
23. D Lacroix A Chateau MP Ginebra JA Planell 2006 Micro-finite element models of bone tissue-engineering scaffolds Biomaterials 27 30 5326 5334 10.1016/j.biomaterials.2006.06.009 10.1016/j.biomaterials.2006.06.009 (Pubitemid 44096958)
24. Lacroix D, Prendergast PJ (2000) A homogenization procedure to prevent numerical instabilities in poroelastic tissue differentiation models. In: Eighth annual symposium: computational methods in orthopaedic biomechanics
25. D Lacroix PJ Prendergast 2002 A mechano-regulation model for tissue differentiation during fracture healing: analysis of gap size and loading J Biomech 35 9 1163 1171 10.1016/S0021-9290(02)00086-6 10.1016/S0021-9290(02) 00086-6 (Pubitemid 34879736)
26. RL Mauck BA Byers X Yuan RS Tuan 2007 Regulation of cartilaginous ECM gene transcription by chondrocytes and MSCs in 3D culture in response to dynamic loading Biomech Model Mechanobiol 6 113 125 10.1007/s10237-006-0042-1 10.1007/s10237-006-0042-1 (Pubitemid 44893166)
27. B McKibbin 1978 The biology of fracture healing in long bones J Bone Joint Surg Br 60-B 2 150 162
28. Perren M, Cordey J (1980) The concept of interfragmentary strain. In: Uhthoff HK(eds) Current concepts of internal fixation of fractures. Springer, Berlin, pp 63-77
29. PJ Prendergast R Huiskes K Soballe 1997 ESB Research Award 1996 Biophysical stimuli on cells during tissue differentiation at implant interfaces. J Biomech 30 6 539 548 10.1016/S0021-9290(96)00140-6 (Pubitemid 27214187)
30. RC Riddle AF Taylor DC Genetos HJ Donahue 2006 MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation Am J Physiol Cell Physiol 290 C776 C784 10.1152/ajpcell.00082.2005 10.1152/ajpcell.00082.2005
31. RL Sah YJ Kim JY Doong AJ Grodzinsky AH Plaas JD Sandy 1989 Biosynthetic response of cartilage explants to dynamic compression J Orthop Res 7 5 619 636 10.1002/jor.1100070502 10.1002/jor.1100070502
32. Salisbury KT, Einhorn TA, Gerstenfeld LC, Morgan EF (2005) Mechanobiological regulation of molecular expression and tissue differentiation during bone healing. Vail, Colorado. Compendex, pp 1530-1531