Impact of initial surgical margins and residual cancer upon re-excision on outcome of patients with localized breast cancer

American Journal of Surgery

Volumn 198, Issue 6, 2009, Pages 771-780

  Kouzminova, Natalia B ^a   Aggarwal, Sangeeta ^a   Aggarwal, Adeeti ^b   Allo, Maria D ^a   Lin, Albert Y ^a  

^a SANTA CLARA VALLEY MEDICAL CENTER   (United States)

^b Saratoga High School   (United States)

Author keywords

Breast cancer; Breast conserving surgery; Distant recurrence; FNA; Local recurrence; Positive margins; Reexcision; Residual tumor; Surgical margins

Indexed keywords

ADULT; ARTICLE; BREAST CANCER; BREAST SURGERY; CANCER CHEMOTHERAPY; CANCER LOCALIZATION; CANCER RECURRENCE; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; HUMAN; INVASIVE CARCINOMA; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL;

ADULT; BREAST NEOPLASMS; FEMALE; HUMANS; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM, RESIDUAL; REOPERATION; RETROSPECTIVE STUDIES; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 71149095263     PISSN: 00029610     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjsurg.2009.05.027     Document Type: Article

References (22)

1. Fisher B., Anderson S., Bryant J., et al. Twenty-year follow-up of randomized trial comparing total mastectomy, lumpectomy and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 347 (2002) 1233-1241
2. Veronesi U., Cascinelli, Mariani L., et al. Twenty-year follow up of a randomized study comparing breast conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 347 (2002) 1227-1232
3. Cady B., Punglia R.S., Morrow M., and Harris J.R. Local therapy and survival in breast cancer. N Engl J Med 357 (2007) 2399-2405
4. Arrigada R., Le M.G., Rochard F., Contesso G., and Institut Gustave-Roussy Breast Cancer Group. Conservative treatment versus mastectomy in early breast cancer: patterns of failure with 15 years of follow-up data. J Clin Oncol 14 (1996) 1558-1564
5. Clarke M., Collins R., Darby S., et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 366 (2005) 2087-2106
6. Mirza N.Q., Vlastos G., Meric F., et al. Predictors of locoregional recurrence among patients with early-stage breast cancer treated with breast-conserving therapy. Ann Surg Oncol 9 (2002) 256-265
7. Van Dongen J.A., Voogd A.C., Fentiman I.S., et al. Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst 92 (2000) 1143-1150
8. Jatoi I., and Proschan M.A. Randomized trials of breast-conserving therapy versus mastectomy for primary breast cancer: a pooled analysis of updated results. Am J Clin Oncol 28 (2005) 289-294
9. Gage I., Schnitt S.J., Nixon A.J., Silver B., et al. Pathologic margin involvement and the risk of recurrence in patients treated with breast-conserving therapy. Cancer 78 (1996) 1921-1928
10. Park C.C., Mitsumori M., Nixon A., et al. Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence. J Clin Oncol 18 (2000) 1668-1675
11. Smitt M.C., Nowels K.W., Zdeblick M.J., et al. The importance of the lumpectomy surgical margin status in long-term results of breast conservation. Cancer 76 (1995) 259-267
12. Vicini F.A., Kestin L., Huang R., and Martinez A. Does local recurrence affect the rate of distant metastases and survival in patients with early-stage breast carcinoma treated with breast-conserving therapy?. Cancer 97 (2003) 910-919
13. Meric F., Mirza N.Q., Vlastos G., et al. Positive surgical margins and ipsilateral breast tumor recurrence predict disease-specific survival after breast-conserving therapy. Cancer 97 (2003) 926-933
14. Jobsen J.J., Van Der Palen J., Ong F., and Meerwaldt J.H. Differences in outcome for positive margins in a large cohort of breast cancer patients treated with breast-conserving therapy. Acta Oncol 46 (2007) 172-180
15. Malik H.Z., George W.D., Mallon E.A., Harnett A.N., Macmillan R.D., and Purushotham A.D. Margin assessment by cavity shaving after breast-conserving surgery: analysis and follow-up of 543 patients. Eur J Surg Oncol 25 (1999) 464-469
16. Malik H.Z., George W.D., Mallon E.A., Harnett A.N., Macmillan R.D., and Purushotham A.D. Tumour bed positivity predicts outcome after breast-conserving surgery. Br J Surg 84 (1997) 1559-1562
17. Smitt M.C., Nowels K., Carlson R.W., and Jeffrey S.S. Predictors of reexcision findings and recurrence after breast conservation. Int J Radiat Oncol Biol Phys 57 (2003) 979-985
18. Gwin J.L., Eisenberg B.L., Hoffman J.P., Ottery F.D., Boraas M., and Solin L.J. Incidence of gross and microscopic carcinoma in specimens from patients with breast cancer after re-excision lumpectomy. Ann Surg 218 (1993) 729-734
19. Kotwall C., Ranson M., Stiles A., and Hamann M.S. Relationship between initial margin status for invasive breast cancer and residual carcinoma after re-excision. Am Surg 73 (2007) 337-343
20. Smitt M.C., and Horst K. Association of clinical and pathologic variables with lumpectomy surgical margin status after preoperative diagnosis or excisional biopsy of invasive breast cancer. Ann Surg Oncol 14 (2007) 1040-1044
21. Tartter P.I., Kaplan J., Bleiweiss I., et al. Lumpectomy margins, re-excision, and local recurrence of breast cancer. Am J Surg 179 (2000) 81-85
22. Waljee J., Hu E., and Newman Lalderman A. Predictors of re-excision among women undergoing breast conserving surgery for cancer. Ann Surg Oncol 15 (2008) 1297-1303