Comprehensive determination of 3JHNHα for unfolded proteins using 13C′-resolved spin-echo difference spectroscopy

Journal of Biomolecular NMR

Volumn 45, Issue 4, 2009, Pages 343-349

  Otten, Renee ^a   Wood, Kathleen ^a   Mulder, Frans A A ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Conformation; HNHA; IDP; IUP; J coupling

Indexed keywords

CARBON 13; NEUROLIGIN; NEUROLIGIN 3; NITROGEN; PROTON; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CORRELATION ANALYSIS; POLARIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE; SPECTROSCOPY; SPIN ECHO DIFFERENCE SPECTROSCOPY;

CARBON ISOTOPES; HUMANS; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; PROTEINS;

EID: 71049194723     PISSN: 09252738     EISSN: 15735001     Source Type: Journal    
DOI: 10.1007/s10858-009-9382-3     Document Type: Article

References (29)

1. AI Bartlett SE Radford 2009 An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms Nature Struct Mol Biol 16 6 582 588 10.1038/nsmb.1592
2. M Billeter D Neri G Otting YQ Qian K Wuthrich 1992 Precise vicinal coupling constants 3JHN-alpha in proteins from nonlinear fits of J-modulated [N-15, H-1]-COSY experiments J Biomol NMR 2 3 257 274 10.1007/BF01875320
3. DA Case C Scheurer R Bruschweiler 2000 Static and dynamic effects on vicinal scalar J couplings in proteins and peptides: a MD/DFT analysis J Am Chem Soc 122 42 10390 10397 10.1021/ja001798p (Pubitemid 30812114)
4. KA Dill D Shortle 1991 Denatures states of proteins Ann Rev Biochem 60 795 825 10.1146/annurev.bi.60.070191.004051
5. D Eliezer 2009 Biophysical characterization of intrinsically disordered proteins Curr Opin Struct Biol 19 1 23 30 10.1016/j.sbi.2008.12.004
6. H Geen R Freeman 1991 Band-selective radiofrequency pulses J Magn Reson 93 1 93 141
7. GS Harbison 1993 Interference between J-couplings and cross-relaxation in solution NMR spectroscopy: consequences for macromolecular structure determination J Am Chem Soc 115 7 3026 3027 10.1021/ja00060a081
8. LE Kay P Keifer T Saarinen 1992 Pure absorption gradient enhanced heteronuclear single quantum correlation spectroscopy with improved sensitivity J Am Chem Soc 114 26 10663 10665 10.1021/ja00052a088
9. J Kördel NJ Skelton M Akke AG Palmer WJ Chazin 1992 Backbone dynamics of calcium-loaded calbindin D9k studied by 2-dimensional proton-detected N-15 NMR-spectroscopy Biochemistry 31 20 4856 4866 10.1021/bi00135a017
10. H Kuboniwa S Grzesiek F Delaglio A Bax 1994 Measurement of HN-Halpha J-couplings in calcium-free calmodulin using new 2D and 3D water flip-back methods J Biomol NMR 4 6 871 878 10.1007/BF00398416
11. C Lendel P Damberg 2009 3D J-resolved NMR spectroscopy for unstructured polypeptides: fast measurement of (3)J(HNH-alpha) coupling constants with outstanding spectral resolution J Biomol NMR 44 1 35 42 10.1007/s10858-009-9313- 3
12. T Mittag JD Forman-Kay 2007 Atomic-level characterization of disordered protein ensembles Curr Opin Struct Biol 17 1 3 14 10.1016/j.sbi.2007.01.009 (Pubitemid 46240819)
13. Mulder FAA, Lundqvist M, Scheek RM (2009) Nuclear magnetic resonance spectroscopy applied to (intrinsically) disordered proteins. In: Uversky V, Longhi S (eds) Assessing structures and conformations of intrinsically disordered proteins. John Wiley and Sons, New Jersey
14. A Paz T Zeev-Ben-Mordehai E Sherman, et al. 2008 Biophysical characterization of the unstructured cytoplasmic domain of the human neuronal adhesion protein neuroligin 3 Biophys J 95 4 1928 1944 10.1529/biophysj.107. 126995
15. A Petit SJF Vincent C Zwahlen 2002 Cosine modulated HSQC: a rapid determination of (3)J(HNH alpha) scalar couplings in N-15-labeled proteins J Magn Reson 156 2 313 317 10.1006/jmre.2002.2538 2002JMagR.156..313P
16. M Piotto V Saudek V Sklenar 1992 Gradient-tailored excitation for single-quantum NMR-spectroscopy of aqueous solutions J Biomol NMR 2 6 661 665 10.1007/BF02192855
17. H Ponstingl G Otting 1998 Rapid measurement of scalar three-bond H-1(N)-H-1(alpha) spin coupling constants in N-15-labelled proteins J Biomol NMR 12 2 319 324 10.1023/A:1008293016073
18. A Rexroth P Schmidt S Szalma T Geppert H Schwalbe C Griesinger 1995 New principles for the determination of coupling constants that largely suppresses differential relaxation effects J Am Chem Soc 117 41 10389 10390 10.1021/ja00146a027
19. DR Shortle 1996 Structural analysis of non-native states of proteins by NMR methods Curr Opin Struct Biol 6 1 24 30 10.1016/S0959-440X(96)80091-1 (Pubitemid 26073941)
20. LA Svensson E Thulin S Forsén 1992 Proline cis-trans isomers in calbindin D9k observed by X-ray crystallography J Mol Biol 223 3 601 606 10.1016/0022-2836(92)90976-Q
21. B Vogeli JF Ying A Grishaev A Bax 2007 Limits on variations in protein backbone dynamics from precise measurements of scalar couplings J Am Chem Soc 129 30 9377 9385 10.1021/ja070324o (Pubitemid 47218806)
22. GW Vuister A Bax 1993 Quantitative J correlation-a new approach for measuring homonuclear 3-bond J(HNHalpha) couplings-constants in N-15 enriched proteins J Am Chem Soc 115 17 7772 7777 10.1021/ja00070a024
23. AC Wang A Bax 1996 Determination of the backbone dihedral angles phi in human ubiquitin from reparametrized empirical Karplus equations J Am Chem Soc 118 10 2483 2494 10.1021/ja9535524 (Pubitemid 26120929)
24. YJ Wang O Jardetzky 2002 Investigation of the neighboring residue effects on protein chemical shifts J Am Chem Soc 124 47 14075 14084 10.1021/ja026811f (Pubitemid 35386860)
25. JJ Ward JS Sodhi LJ McGuffin BF Buxton DT Jones 2004 Prediction and functional analysis of native disorder in proteins from the three kingdoms of life J Mol Biol 337 3 635 645 10.1016/j.jmb.2004.02.002 (Pubitemid 38326883)
26. Wirmer J, Schlörb C, Schwalbe H (2005) Conformation and dynamics of nonnative states of proteins studied by NMR spectroscopy. In: Buchner J, Kiefhaber T (eds) Protein folding handbook part I. Wiley-VCH, Weinheim, pp 737-808
27. DS Wishart CG Bigam A Holm RS Hodges BD Sykes 1995 H-1, C-13 and N-15 random coil NMR chemical-shifts of the common amino-acids.1. Investigations of nearest-neighbor effects J Biomol NMR 5 1 67 81 10.1007/BF00227471
28. D Yang LE Kay 1999 Improved lineshape and sensitivity in the HNCO-family of triple resonance experiments J Biomol NMR 14 3 273 276 10.1023/A: 1008381929212 (Pubitemid 29396485)
29. J Yao HJ Dyson PE Wright 1997 Chemical shift dispersion and secondary structure prediction in unfolded and partly folded proteins FEBS Lett 419 2-3 285 289 10.1016/S0014-5793(97)01474-9 (Pubitemid 28010828)