Sustained first remission in an adolescent with hepatosplenic T-cell lymphoma treated with T-cell leukemia induction, nucleoside analog-based consolidation, and early hematopoietic stem cell transplant

Pediatric Blood and Cancer

Volumn 53, Issue 6, 2009, Pages 1127-1129

  Schafer, Eric ^a   Chen, Allen ^a   Arceci, Robert J ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Delta gamma lymphoma; GVHD; Hepatosplenic T cell lymphoma; Nucleoside analog; Transplant

Indexed keywords

ASPARAGINASE MACROGOL; CD2 ANTIGEN; CD3 ANTIGEN; CD45 ANTIGEN; CD56 ANTIGEN; CD7 ANTIGEN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; CYTARABINE; DAUNORUBICIN; FLUDARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN; LEVOTHYROXINE; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NUCLEOSIDE ANALOG; PREDNISONE; RAPAMYCIN; VINCRISTINE;

ADOLESCENT; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANEMIA; ARTICLE; BONE MARROW BIOPSY; BRAIN DISEASE; CANCER REGRESSION; CASE REPORT; CHILDHOOD CANCER; CHROMOSOME ANALYSIS; DRUG DOSE REDUCTION; DRUG PULSE THERAPY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ERYTHROCYTE TRANSFUSION; ERYTHRODERMA; FEMALE; FEVER; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GASTROINTESTINAL TOXICITY; GRAFT VERSUS HOST REACTION; HEMATURIA; HEPATOMEGALY; HEPATOSPLENIC T CELL LYMPHOMA; HUMAN; HYPOTHYROIDISM; IMMUNOPHENOTYPING; PREMATURE OVARIAN FAILURE; PRIORITY JOURNAL; SPLENOMEGALY; SYNCOPE; T CELL LYMPHOMA; ULTRAVIOLET B RADIATION; VIRUS ENCEPHALITIS; WHOLE BODY RADIATION;

ADOLESCENT; ANTINEOPLASTIC AGENTS; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LEUKEMIA, T-CELL; LIVER NEOPLASMS; LYMPHOMA, T-CELL; NUCLEOSIDES; REMISSION INDUCTION; SPLENIC NEOPLASMS; TREATMENT OUTCOME;

EID: 71049191087     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.22129     Document Type: Article

References (19)

1. Belhadj K, Reyes F, Farcet JP, et al. Hepatosplenic gamma delta T-cell lymphoma is a rare clinicopathologic entity with poor outcome: Report on a series of 21 patients. Blood 2003;102:4261-4269. (Pubitemid 37494082)
2. Weidmann E. Hepatosplenic T cell lymphoma. A review on 45 cases since the first report describing the disease as a distinct lymphoma entity in 1990. Leukemia 2000;14:991-997.
3. Beetz S, Wesch D, Marischen L, et al. Innate immune functions of human gamma delta T cells. Immunobiology 2008;213:173-182.
4. Casetti R, Martino A. The plasticity of gamma delta T cells: Innate immunity, antigen presentation and new immunotherapy. Cell Mol Immunol 2008;5:161-170.
5. Xiong N, Raulet DH. Development and selection of gamma delta T cells. Immunol Rev 2007;215:15-31. (Pubitemid 46212227)
6. Gaulard P, Belhadj K, Reyes F. Gamma delta T-cell lymphomas. Semin Hematol 2003;40:233-243.
7. Jaffe ES, Harris NL, Stein H, et al. Classification of lymphoid neoplasms: The microscope as a tool for disease discovery. Blood 2008;112:4384-4399.
8. Toro JR, Liewehr DJ, Pabby N, et al. Gamma-delta T-cell phenotype is associated with significantly decreased survival in cutaneous T-cell lymphoma. Blood 2003;101:3407-3412. (Pubitemid 36857921)
9. Farcet JP, Gaulard P, Marolleau JP, et al. Hepatosplenic T-cell lymphoma: Sinusal/sinusoidal localization of malignant cells expressing the T-cell receptor gamma delta. Blood 1990;75: 2213-2219. (Pubitemid 20181173)
10. He S, Roberts A, Ritchie D, et al. Graft-versus-lymphoma effect in progressive hepatosplenic gamma/delta T-cell lymphoma. Leuk Lymphoma 2007;48:1448-1450. (Pubitemid 47079380)
11. Mittal S, Milner BJ, Johnston PW, et al. A case of hepatosplenic gamma-delta T-cell lymphoma with a transient response to fludarabine and alemtuzumab. Eur J Haematol 2006;76:531-534.
12. Jaeger G, Bauer F, Brezinschek R, et al. Hepatosplenic gamma delta T-cell lymphoma successfully treated with a combination of alemtuzumab and cladribine. Ann Oncol 2008;19:1025-1026. (Pubitemid 351627329)
13. Sallah S, Smith SV, Lony LC, et al. Gamma/delta T-cell hepatosplenic lymphoma: Review of the literature, diagnosis by flow cytometry and concomitant autoimmune hemolytic anemia. Ann Hematol 1997;74:139-142. (Pubitemid 27182326)
14. Yao M, Tien HF, Lin MT, et al. Clinical and hematological characteristics of hepatosplenic T gamma/delta lymphoma with isochromosome for long arm of chromosome 7. Leuk Lymphoma 1996;22:495-500. (Pubitemid 26341016)
15. Tey SK, Marlton PV, Hawley CM, et al. Post-transplant hepatosplenic T-cell lymphoma successfully treated with Hyper- CVAD regimen. Am J Hematol 2008;83:330-333.
16. Sakai R, Fujisawa S, Fujimaki K, et al. Long-term remission in a patient with hepatosplenic gamma delta T cell lymphoma after cord blood stem cell transplantation following autologous peripheral blood stem cell transplantation. Bone Marrow Transplant 2006;37: 537-538.
17. Domm JA, Thompson M, Kuttesch JF, et al. Allogeneic bone marrowtransplantation for chemotherapy-refractory hepatosplenic gamma delta T-cell lymphoma: Case report and review of the literature. J Pediatr Hematol Oncol 2005;27:607-610. (Pubitemid 41697349)
18. Ooi J, Iseki T, Adachi D, et al. Successful allogeneic bone marrow transplantation for hepatosplenic gammadelta T cell lymphoma. Haematologica 2001;86:E25.
19. Le Gouill S, Milpied N, Buzyn A, et al. Graft-versus-lymphoma effect for aggressive T-cell lymphomas in adults: A study by the Societe Francaise de Greffe de Moelle et de Therapie Cellulaire. J Clin Oncol 2008;26:2264-2271.