Characterization of a rat model of moderate chronic renal failurefocus on hematological, biochemical, and cardio-renal profiles

Renal Failure

Volumn 31, Issue 9, 2009, Pages 833-842

  Garrido, P ^a   Reis, F ^a,b   Costa, E ^b,c   Teixeira Lemos, E ^a   Parada, B ^a,d   Alves, R ^a,d   Piloto, N ^a   Sereno, J ^a   Figueiredo, A ^a,d   Pinto, R ^e   Carvalho, L ^f   Rocha Pereira, P ^b,g   Belo, L ^b,h   Santos Silva, A ^b,h   Teixeira, F ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c CBQF CENTRO DE BIOTECNOLOGIA E QUÍMICA FINA LABORATÓRIO ASSOCIADO   (Portugal)

^d CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^e UNIVERSITY OF LISBON   (Portugal)

^f UNIVERSITY OF COIMBRA   (Portugal)

^g UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^h UNIVERSITY OF PORTO   (Portugal)

Author keywords

Cardio renal characterization; Inflammation; Moderate renal failure; Oxidative stress; Sympathetic activity

Indexed keywords

ADRENERGIC SYSTEM; ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; BLOOD EXAMINATION; CHEMICAL ANALYSIS; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; DYSLIPIDEMIA; HEMATOLOGIC DISEASE; HISTOPATHOLOGY; HYPERTENSION; INFLAMMATORY INFILTRATE; IRON METABOLISM; KIDNEY FUNCTION; KIDNEY HYPERTROPHY; LIPID BLOOD LEVEL; MALE; NONHUMAN; OXIDATIVE STRESS; PARTIAL NEPHRECTOMY; PRIORITY JOURNAL; RAT; SYMPATHETIC TONE;

ANIMALS; CARDIOVASCULAR DISEASES; DISEASE MODELS, ANIMAL; INFLAMMATION; KIDNEY FAILURE, CHRONIC; MALE; NEPHRECTOMY; OXIDATIVE STRESS; RATS; RATS, WISTAR; SYMPATHETIC NERVOUS SYSTEM;

EID: 71049184825     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.3109/08860220903151435     Document Type: Article

References (31)

1. Parmar MS. Chronic renal disease. BMJ. 2002;325:85-90.
2. Kerr PG. Renal anemia: Recent developments, innovative approaches and future directions for improved management. Nephrology (Carlton). 2006;11:542-548.
3. Stenvinkel P. Anaemia and inflammation: What are the implications for the nephrologists? Nephrol Dial Transplant. 2003;18:viii17-viii22.
4. Costa E, Pereira BJ, Rocha-Pereira P, et al. Role of prohepcidin, inflammatory markers and iron status in resistance to rhEPO therapy in hemodialysis patients. Am J Nephrol. 2008;28:677-683.
5. Koomans HA, Blankestijn PJ, Joles JA. Sympathetic hyperactivity in chronic renal failure: A wake-up call. J Am Soc Nephrol. 2004;15:524-537.
6. Bakris GL. Protecting renal function in the hypertensive patient: Clinical guidelines. Am J Hypertens. 2005;18:112S-119S.
7. Liu ZC, Chow KM, Chang TM. Evaluation of two protocols of uremic rat model: Partial nephrectomy and infarction. Ren Fail. 2003;25:935-943.
8. Ofstad J, Horvei G, Kvam FI, et al. Glomerular hemodynamics in progressive renal disease. Kidney Int. 1992;36:S8-S14.
9. Fine L. The biology of renal hypertrophy. Kidney Int. 1986;29:619-634.
10. Gretz N, Waldherr R, Strauch M. The remnant kidney model. In: Gretz N, Strauch M (eds.). Experimental and genetic rat models of chronic renal failure. Basel: Karger; 1993:1-28.
11. Hostetter TH, Olson JL, Rennke HG, et al. Hyperfiltration in remnants nephrons: A potentially adverse response to renal ablation. J Am Soc Nephrol. 2001;12:1315-1325.
12. Toblli JE, Cao G, Rivas C, Kulaksiz H. Heart and iron deficiency anaemia in rats with renal insufficiency: The role of hepcidin. Nephrology (Carlton). 2008;13:636-645.
13. Reis F, Rocha L, Ponte L, et al. Effect of preventive and regressive isosorbide 5-mononitrate treatment on catecholamine levels in plasma, platelets, adrenals, left ventricle and aorta in cyclosporin A-induced hypertensive rats. Life Sci. 2005;77:2514-2528.
14. Estepa V, Ródenas S, Martín MC. Optimización de un método para la determinación de la peroxidación lipídica en suero humano. Anal Real Acad Farm. 2001;67:1-17.
15. Benzie IFF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of ''antioxidant power'': The FRAP assay. Anal Biochem. 1996;239:70-76.
16. Remuzzi G, Ruggenenti P, Perico N. Chronic renal diseases: Renoprotective benefits of renin-angiotensin system inhibition. Ann Intern Med. 2002;136:604-615.
17. Schnaper HW, Jandeska S, Runyan CE, Hubchak SC, Basu RK, Curley JF, Smith RD, Hayashida T. TGF-beta signal transduction in chronic kidney disease. Front. Biosci. 2009;14: 2448-2465.
18. Hörl WH. Iron therapy for renal anemia: How much needed, how much harmful? Pediatr Nephrol. 2007;22:480-489.
19. Brugnara C. Iron deficiency and erythropoiesis: New diagnostic approaches. Clin Chem. 2003;49:1573-1578.
20. Oschry Y, Eisenberg S. Rat plasma lipoproteins: Re-evaluation of a lipoprotein system in an animal devoid of cholesteryl ester transfer activity. J Lipid Res. 1982;23:1099-1106.
21. Tsimihodimos V, Dounousi E, Siamopoulos KC. Dyslipidemia in chronic kidney disease: An approach to pathogenesis and treatment. Am J Nephrol. 2008;28:958-973.
22. Johnson DW, Armstrong K, Campbell SB, et al. Metabolic syndrome in severe chronic kidney disease: Prevalence, predictors, prognostic significance and effects of risk factor modification. Nephrology (Carlton). 2007;12:391-398.
23. Chan CM. Hyperlipidemia in chronic renal disease. Ann Acad Med Singapore. 2005;35:31-35.
24. Silverberg D, Wexler D, Blum M, et al. The cardio-renal anaemia syndrome: Does it exist? Nephrol Dial Transplant. 2003;18:viii7-viii12.
25. Wexler D, Silverberg D, Blum M, et al. Anaemia as a contributor to morbidity and mortality in congestive heart failure. Nephrol Dial Transplant. 2005;20:vii11-vii15.
26. Ritz E, Koomans HA. New insights into mechanisms of blood pressure regulation in patients with uremia. Nephrol Dial Transplant. 1996;11:52-59.
27. Campese VM. Neurogenic factors and hypertension in chronic renal failure. J Nephrol. 1997;10:184-187.
28. Malyszko J, Malyszko JS, Pawlak D, et al. Homeostasis, platelet function and serotonin in acute and chronic renal failure. Thromb Res. 1996;83:351-361.
29. Hojs R, Hojs-Fabjan T, Balon BP. Atherosclerosis in patients with end-stage renal failure prior to initiation of hemodialysis. Ren Fail. 2003;25:247-254.
30. Martín-Mateo MC, Sánchez-Portugal M, Iglesias S, De Paula A, Bustamante J. Oxidative stress in chronic renal failure. Ren Fail. 1999;21:155-167.
31. Manning RD Jr, Tian N, Meng S. Oxidative stress and antioxidant treatment in hypertension and the associated renal damage. Am J Nephrol. 2005;25: 311-317.