Medical application of hydrogen molecule: Recent progress

Academic Journal of Second Military Medical University

Volumn 30, Issue 10, 2009, Pages 1203-1205

  Zhang, Wei ^a   Cai, Jian Mei ^a   Kang, Zhi Min ^a   Sun, Xue Jun ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antioxidant; Hydrogen; Medical hydrogen molecule

Indexed keywords

HYDROGEN;

ANTIOXIDANT ACTIVITY; BIOLOGICAL ACTIVITY; MEDICAL RESEARCH; MOLECULE; REVIEW;

EID: 71049175442     PISSN: 0258879X     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1008.2009.01203     Document Type: Review

References (27)

1. -) in aqueous solution[J]. J Phys Chem Ref Data, 1988,17:513-886.
2. Kayar S R, Axley M J, Homer L D, Harabin A L. Hydrogen gas is not oxidized by mammalian tissues under hyperbaric conditions[J]. Undersea Hyperb Med, 1994,21:265-275.
3. Dole M, Wilson F R, Fife W P. Hyperbaric hydrogen therapy: a possible treatment for cancer[J]. Science, 1975,190:152-154.
4. Gharib B, Hanna S, Abdallahi O M, Lepidi H, Gardette B, De Reggi M. Anti-inflammatory properties of molecular hydrogen, investigation on parasite-induced liver inflammation[J]. C R Acad Sci III, 2001,324:719-724. (Pubitemid 32707449)
5. Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, et al. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals[J]. Nat Med, 2007,13:688-694. (Pubitemid 46889750)
6. Wood K C, Gladwin M T. The hydrogen highway to reperfusion therapy[J]. Nat Med, 2007,13:673-674.
7. Singhal A B, Lo E H. Advances in emerging nondrug therapies for acute stroke 2007[J]. Stroke, 2008,39:289-291.
8. Sun X J, Zhang J H. Hydrogen - an endogenous antioxidant in the body[J]. Acad J Sec Mil Med Univ, 2008,29:233-235.
9. Fukuda K I, Asoh S, Ishikawa M, Yamamoto Y, Ohsawa I, Ohta S. Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress[J]. Biochem Biophys Res Commun, 2007,361:670-674. (Pubitemid 47238041)
10. Hayashida K, Sano M, Ohsawa I, Shinmura K, Tamaki K, Kimura K, et al. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury[J]. Biochem Biophys Res Commun, 2008,373:30-35.
11. Ohsawa I, Nishimaki K, Yamagata K, Ishikawa M, Ohta S. Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice[J]. Biochem Biophys Res Commun, 2008,377:1195-1198.
12. Kajiyama S, Hasegawa G, Asano M, Hosoda H, Fukui M, Nakamura N, et al. Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance[J]. Nutr Res, 2008,28:137-143.
13. Sato Y, Kajiyama S, Amano A, Kondo Y, Sasaki T, Handa S, et al. Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice[J]. Biochem Biophys Res Commun, 2008,375:346-350.
14. Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S. Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice[J]. Neuropsychopharmacology, 2009,34:501-508.
15. Nakashima-Kamimura N, Mori T, Ohsawa I, Asoh S, Ohta S. Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice[J]. Cancer Chemother Pharmacol, 2009,64:753-761.
16. Fu Y, Ito M, Fujita Y, Ito M, Ichihara M, Masuda A, et al. Molecular hydrogen is protective against 6-hydroxydopamine -induced nigrostriatal degeneration in a rat model of Parkinson's disease[J]. Neurosci Lett, 2009,453:81-85.
17. Buchholz B M, Kaczorowski D J, Sugimoto R, Yang R, Wang Y, Billiar T R, et al. Hydrogen inhalation ameliorates oxidative stress in transplantation induced intestinal graft injury[J]. Am J Transplant, 2008,8:2015-2024.
18. Cai J, Kang Z, Liu W W, Luo X, Qiang S, Zhang J H, et al. Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model[J]. Neurosci Lett, 2008,441:167-172.
19. Cai J, Kang Z, Liu K, Liu W, Li R, Zhang J H, et al. Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model[J]. Brain Res, 2009,1256:129-137.
20. Mao Y F, Zheng X F, Cai J M, You X M, Deng X M, Zhang J H, et al. Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats[J]. Biochem Biophys Res Commun, 2009,381:602-605.
21. Zheng X, Mao Y, Cai J, Li Y, Liu W, Sun P, et al. Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats[J]. Free Radic Res, 2009,43:478-484.
22. Abraini J H, Gardette-Chauffour M C, Martinez E, Rostain J C, Lemaire C. Psychophysiological reactions in humans during an open sea dive to 500 m with a hydrogen-helium-oxygen mixture[J]. J Appl Physiol, 1994,76:1113-1138. (Pubitemid 24099948)
23. Chan P H. Role of oxidants in ischemic brain damage[J]. Stroke, 1996,27:1124-1129.
24. Liu S, Liu M, Peterson S, Miyake M, Vallyathan V, Liu K J. Hydroxyl radical formation is greater in striatal core than in penumbra in a rat model of ischemic stroke[J]. J Neurosci Res, 2003,71:882-888. (Pubitemid 36293009)
25. Nanetti L, Taffi R, Vignini A, Moroni C, Raffaelli F, Bacchetti T, et al. Reactive oxygen species plasmatic levels in ischemic stroke[J]. Mol Cell Biochem, 2007,303:19-25. (Pubitemid 47261297)
26. Olson J W, Maier R J. Molecular hydrogen as an energy source for Helicobacter pylori[J]. Science, 2002,298:1788-1790. (Pubitemid 35404122)
27. Simren M, Stotzer P O. Use and abuse of hydrogen breath tests[J]. Gut, 2006,55:297-303.