New tricyclic geldanamycin analogues from an engineered strain of Streptomyces hygroscopicus JCM4427

Tetrahedron Letters

Volumn 51, Issue 2, 2010, Pages 351-353

  Hong, Seong Su ^a   Cai, Xing Fu ^b   Hwang, Bang Yeon ^c   Lee, Hong Sub ^d   Su, Bao Ning ^e   Hong, Young Soo ^b   Lee, Dongho ^a  

^a Korea University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Chungbuk National University   (South Korea)

^d ILDONG Pharmaceutical Co   (South Korea)

^e OHIO STATE UNIVERSITY   (United States)

Author keywords

Streptomyces hygroscopicus; Tricyclic geldanamycin analogues

Indexed keywords

GELDANAMYCIN; HYDROXYL GROUP; POLYKETIDE SYNTHASE;

ADDITION REACTION; ALKYLATION; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; CHEMICAL BOND; DRUG STRUCTURE; GENE INACTIVATION; SITE DIRECTED MUTAGENESIS; STREPTOMYCES HYGROSCOPICUS;

STREPTOMYCES HYGROSCOPICUS;

EID: 71049171242     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.11.018     Document Type: Article

References (15)

1. Barginear M.F., Van Poznak C., Rosen N., Modi S., Hudis C.A., and Budman D.R. Curr. Cancer Drug Target 8 (2008) 522
2. Mahalingam D., Swords R., Carew J.S., Nawrocki S.T., Bhalla K., and Giles F.J. Br. J. Cancer 100 (2009) 1523
3. Karapanagiotou E.M., Syrigos K., and Saif M.W. Exp. Opin. Invest. Drugs 18 (2009) 161
4. Taldone T., Gozman A., Maharaj R., and Chiosis G. Curr. Opin. Pharm. 8 (2008) 370
5. Stravopodis D.J., Margaritis L.H., and Voutsinas G.E. Curr. Med. Chem. 14 (2007) 3122
6. Rascher A., Hu Z., Viswanathan N., Schirmer A., Reid R., Nierman W.C., Lewis M., and Hutchinson C.R. FEMS Microbiol. Lett. 218 (2003) 223
7. Hong Y.S., Lee D., Kim W., Jeong J.K., Kim C.G., Sohng J.K., Lee J.H., Paik S.G., and Lee J.J. J. Am. Chem. Soc. 126 (2004) 11142
8. Lee D., Lee K., Cai X.F., Dat N.T., Boovanahalli S.K., Lee M., Shin J.C., Kim W., Jeong J.K., Lee J.S., Lee C.H., Lee J.H., Hong Y.S., and Lee J.J. ChemBiochem 7 (2006) 246
9. Shin J.C., Na Z., Lee D.H., Kim W.C., Lee K., Shen Y.M., Paik S.G., Hong Y.S., and Lee J.J. J. Microbiol. Biotechnol. 18 (2008) 1101
10. Kim W., Lee D., Hong S.S., Na Z., Shin J.C., Roh S.H., Wu C.Z., Choi O., Lee K., Shen Y.M., Paik S.G., Lee J.J., and Hong Y.S. ChemBiochem 10 (2009) 1243
11. Kim W., Lee J.S., Lee D., Cai X.F., Shin J.C., Lee K., Lee C.H., Ryu S., Paik S.G., Lee J.J., and Hong Y.S. ChemBiochem 8 (2007) 1491
12. 13C NMR data, see Table 1.
13. 13C NMR data, see Table 1.
14. Hu Z., Liu Y., Tian Z.Q., Ma W., Starks C.M., Regentin R., Licari P., Myles D.C., and Hutchinson C.R. J. Antibiot. 57 (2004) 421
15. Lee K., Ryu J.S., Jin Y., Kim W., Kaur N., Chung S.J., Jeon Y.J., Park J.T., Bang J.S., Lee H.S., Kim T.Y., Lee J.J., and Hong Y.S. Org. Biomol. Chem. 6 (2008) 340