Treatment with sirolimus ameliorates tacrolimus-induced autoimmune cytopenias after solid organ transplant

Pediatric Blood and Cancer

Volumn 53, Issue 6, 2009, Pages 1114-1116

  Teachey, David T ^a   Jubelirer, Tracey ^a   Baluarte, H Jorge ^a   Wade, Amanda ^a   Manno, Catherine S ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Immune cytopenias; mTOR; Signal transduction therapeutics

Indexed keywords

CORTICOSTEROID; CYCLOSPORIN; DILTIAZEM; HEMOGLOBIN; IMMUNOGLOBULIN G; LACTATE DEHYDROGENASE; METHYLPREDNISOLONE; PREDNISONE; RAPAMYCIN; TACROLIMUS;

ADOLESCENT; ALLOGRAFT; ANEMIA; ARTICLE; AUTOIMMUNE HEMOLYTIC ANEMIA; AUTOIMMUNITY; CASE REPORT; CYTOPENIA; DIZZINESS; DRUG DOSE REDUCTION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; DYSPNEA; EYE JAUNDICE; FATIGUE; HEART PALPITATION; HEMOGLOBIN BLOOD LEVEL; HUMAN; IMMUNE DEFICIENCY; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; ORGAN TRANSPLANTATION; PALLOR; PRIORITY JOURNAL; RETICULOCYTE COUNT; SORE THROAT; SPHEROCYTOSIS; SPLENOMEGALY; T LYMPHOCYTE; WEAKNESS;

ADOLESCENT; AUTOIMMUNE DISEASES; HEART TRANSPLANTATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LIVER TRANSPLANTATION; MALE; ORGAN TRANSPLANTATION; PANCYTOPENIA; SIROLIMUS; TACROLIMUS;

EID: 71049153778     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.22183     Document Type: Article

References (13)

1. Tubman VN, Smoot L, Heeney MM. Acquired immune cytopenias post-cardiac transplantation respond to rituximab. Pediatr Blood Cancer 2007;48:339-344. (Pubitemid 46238527)
2. Valent P, Lechner K. Diagnosis and treatment of autoimmune haemolytic anaemias in adults: A clinical review. Wien Klin Wochenschr 2008;120:136-151.
3. Chen FE, Owen I, Savage D, et al. Late onset haemolysis and red cell autoimmunisation after allogeneic bone marrow transplant. Bone Marrow Transplant 1997;19:491-495. (Pubitemid 27102017)
4. Teachey DT, Felix CA. Development of cold agglutinin autoimmune hemolytic anemia during treatment for pediatric acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2005;27:397-399. (Pubitemid 41077031)
5. Brusko TM, Putnam AL, Bluestone JA. Human regulatory T cells: Role in autoimmune disease and therapeutic opportunities. Immunol Rev 2008;223:371-390. (Pubitemid 351986182)
6. Zuber J, Brodin-Sartorius A, Thervet E, et al. Cyclosporine abrogates de novo generation of Tregs independently of IL-2. Am J Transplant 2007;7:2645 (author reply 2646).
7. Noris M, Casiraghi F, Todeschini M, et al. Regulatory T cells and T cell depletion: Role of immunosuppressive drugs. JAm Soc Nephrol 2007;18:1007-1018. (Pubitemid 46434518)
8. Demirkiran A, Hendrikx TK, Baan CC, et al. Impact of immunosuppressive drugs onCD4+ CD25+ FOXP3+ regulatory T cells: Does in vitro evidence translate to the clinical setting? Transplantation 2008;85:783-789.
9. Teachey DT, Greiner R, Seif AE, et al. Treatment with sirolimus results in complete responses in patients with autoimmune lymphoproliferative syndrome. Br J Haematol 2009;145:101-106.
10. Ramos-Barron A, Pinera-Haces C, Gomez-Alamillo C, et al. Prevention of murine lupus disease in (NZBxNZW)F1 mice by sirolimus treatment. Lupus 2007;16:775-781. (Pubitemid 350069789)
11. Baldo P, Cecco S, Giacomin E, et al. mTOR pathway and mTOR inhibitors as agents for cancer therapy. Curr Cancer Drug Targets 2008;8:647-665.
12. Flechner SM, Kobashigawa J, Klintmalm G. Calcineurin inhibitorsparing regimens in solid organ transplantation: Focus on improving renal function and nephrotoxicity. Clin Transplant 2008;22:1-15. (Pubitemid 351149996)
13. Raj K, Narayanan S, Augustson B, et al. Rituximab is effective in the management of refractory autoimmune cytopenias occurring after allogeneic stem cell transplantation. Bone MarrowTransplant 2005;35:299-301. (Pubitemid 40268303)