Cyclosporine abrogates de novo generation of tregs independently of IL-2 [5]

American Journal of Transplantation

Volumn 7, Issue 11, 2007, Pages 2645-

  Zuber, J ^a   Brodin Sartorius, A ^a   Thervet, E ^a   Legendre, C ^a  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; INTERLEUKIN 2; PHOSPHATASE; TRANSCRIPTION FACTOR FOXP3;

ADAPTATION; BINDING SITE; ENZYME ACTIVITY; HOMEOSTASIS; HUMAN; LETTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; TRANSCRIPTION INITIATION; TRANSPLANTATION;

ANIMALS; CYCLOSPORINE; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; MICE; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 35248829946     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2007.01970.x     Document Type: Letter

References (5)

1. Kang HG, Zhang D, Degauque N, Mariat C, Alexopoulos S, Zheng XX. Effects of cyclosporine on transplant tolerance: The role of IL-2. Am J Transplant 2007 7 : 1907 1916.
2. Vukmanovic-Stejic M, Zhang Y, Cook JE et al. Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo. J Clin Invest 2006 116 : 2423 2433.
3. Zuber J, Viguier M, Lemaitre F et al. Severe FOXP3+ and naive T lymphopenia in a non-IPEX form of autoimmune enteropathy combined with an immunodeficiency. Gastroenterology 2007 132 : 1694 1704.
4. Mantel PY, Ouaked N, Ruckert B et al. Molecular mechanisms underlying FOXP3 induction in human T cells. J Immunol 2006 176 : 3593 3602.
5. Gao W, Lu Y, El Essawy B, Oukka M, Kuchroo VK, Strom TB. Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells. Am J Transplant 2007 7 : 1722 1732.