Area of residual tumor beyond the muscular layer is a useful predictor of outcome in rectal cancer patients who receive preoperative chemoradiotherapy

Pathology International

Volumn 59, Issue 12, 2009, Pages 857-862

  Kojima, Motohiro ^a   Ishii, Genichiro ^a   Yamane, Yuki ^a   Nishizawa, Yuji ^a   Saito, Norio ^a   Ochiai, Atsushi ^a  

^a NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

Author keywords

Chemoradiation; Morphometry; Prognosis; Rectal cancer

Indexed keywords

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER STAGING; CLINICAL ARTICLE; DISEASE COURSE; DISEASE FREE SURVIVAL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; MORPHOMETRICS; MUSCLE TUMOR; PRIORITY JOURNAL; RECTUM CANCER; RECTUM SURGERY; TREATMENT OUTCOME; TUMOR LOCALIZATION; TUMOR RECURRENCE; TUMOR REGRESSION;

ANTINEOPLASTIC AGENTS; COMBINED MODALITY THERAPY; DIGESTIVE SYSTEM SURGICAL PROCEDURES; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM STAGING; NEOPLASM, RESIDUAL; PROGNOSIS; RADIOTHERAPY; RECTAL NEOPLASMS; TREATMENT OUTCOME;

EID: 71049150832     PISSN: 13205463     EISSN: 14401827     Source Type: Journal    
DOI: 10.1111/j.1440-1827.2009.02464.x     Document Type: Article

References (19)

1. Improved survival with preoperative radiotherapy in resectable rectal cancer. Swedish Rectal Cancer Rrial. N Engl J Med 1997 336 : 980 987.
2. Sauer R, Becker H, Hohenberger W et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med 2004 351 : 1731 1740.
3. Glimelius B, Sorbye H, Balteskard L et al. A randomized phase III multicenter trial comparing irinotecan in combination with the Nordic bolus 5-FU and folinic acid schedule or the bolus/infused de Gramont schedule (Lv5FU2) in patients with metastatic colorectal cancer. Ann Oncol 2008 19 : 909 914.
4. Kapiteijn E, Marijnen CA, Nagtegaal ID et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001 345 : 638 646. (Pubitemid 34936565)
5. Dworak O, Keilholz L, Hoffmann A. Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorectal Dis 1997 12 : 19 23.
6. Rodel C, Martus P, Papadoupolos T et al. Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer. J Clin Oncol 2005 23 : 8688 8696.
7. Wheeler JM, Warren BF, Jones AC, Mortensen NJ. Preoperative radiotherapy for rectal cancer: Implications for surgeons, pathologists and radiologists. Br J Surg 1999 86 : 1108 1120.
8. Garcia-Aguilar J, Pollack J, Lee SH et al. Accuracy of endorectal ultrasonography in preoperative staging of rectal tumors. Dis Colon Rectum 2002 45 : 10 15.
9. Kodner IJ, Shemesh EI, Fry RD et al. Preoperative irradiation for rectal cancer. Improved local control and long-term survival. Ann Surg 1989 209 : 194 199.
10. Janjan NA, Abbruzzese J, Pazdur R et al. Prognostic implications of response to preoperative infusional chemoradiation in locally advanced rectal cancer. Radiother Oncol 1999 51 : 153 160.
11. Wheeler JM, Warren BF, Mortensen NJ et al. Quantification of histologic regression of rectal cancer after irradiation: A proposal for a modified staging system. Dis Colon Rectum 2002 45 : 1051 1056.
12. Sobin LH, Wittekind C. TNM Classification of Malignant Tumors, 6th edn. New York : John Wiley and Sons, 2002.
13. Compton CC, Fielding LP, Burgart LJ et al. Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med 2000 124 : 979 994.
14. Theodoropoulos G, Wise WE, Padmanabhan A et al. T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival. Dis Colon Rectum 2002 45 : 895 903.
15. Ruo L, Tickoo S, Klimstra DS et al. Long-term prognostic significance of extent of rectal cancer response to preoperative radiation and chemotherapy. Ann Surg 2002 236 : 75 81.
16. Rullier A, Laurent C, Capdepont M et al. Lymph nodes after preoperative chemoradiotherapy for rectal carcinoma: Number, status, and impact on survival. Am J Surg Pathol 2008 32 : 45 50.
17. Kaminsky-Forrett MC, Conroy T, Luporsi E et al. Prognostic implications of downstaging following preoperative radiation therapy for operable T3-T4 rectal cancer. Int J Radiat Oncol Biol Phys 1998 42 : 935 941.
18. Berger C, de Muret A, Garaud P et al. Preoperative radiotherapy (RT) for rectal cancer: Predictive factors of tumor downstaging and residual tumor cell density (RTCD): Prognostic implications. Int J Radiat Oncol Biol Phys 1997 37 : 619 627.
19. Lim SB, Choi HS, Jeong SY et al. Optimal surgery time after preoperative chemoradiotherapy for locally advanced rectal cancers. Ann Surg 2008 248 : 243 251.