Implications of conflicting associations of the prion protein (PrP) gene with scrapie susceptibility and fitness on the persistence of scrapie

PLoS ONE

Volumn 4, Issue 11, 2009, Pages

  Doeschl Wilson, Andrea ^a   Sawalha, Rami ^a   Gubbins, Simon ^b   Villanueva, Beatriz ^a,c  

^a SCOTTISH AGRICULTURAL COLLEGE   (United Kingdom)

^b INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^c INIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; MATHEMATICAL MODEL; MORTALITY; NONHUMAN; PREVALENCE; SCRAPIE; ALGORITHM; ANIMAL; DISEASE PREDISPOSITION; GENETIC PREDISPOSITION; GENETICS; PHYSIOLOGY; PRION; SHEEP; STATISTICAL MODEL; STATISTICS; THEORETICAL MODEL;

OVIS ARIES;

ALGORITHMS; ANIMALS; DISEASE SUSCEPTIBILITY; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; MODELS, STATISTICAL; MODELS, THEORETICAL; PRIONS; SCRAPIE; SHEEP; STOCHASTIC PROCESSES;

EID: 71049127475     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007970     Document Type: Article

References (28)

1. Detwiler LA, Baylis M (2003) The epidemiology of scrapie. Rev Sci Tech Off Int Epiz 22: 121-143.
2. Goldmann W, Hunter N, Smith G, Foster JD, Hope J (1994) PrP genotype and agent effects in scrapie: change in allelic interaction with different isolates of agent in sheep, a natural host of scrapie. J Gen Virol 75: 989-995.
3. Hunter N, Goldman W, Foster JD, Cairns D, Smith G (1997a) Natural scrapie and PrP genotype: case-control studies in British sheep. Vet Rec 141: 137-140.
4. Hunter N, Cairns D, Foster JD, Smith G, Goldman W, et al. (1997b) Is scrapie solely a genetic disease? Nature 386: 137.
5. Roden JA, Nieuwhof GJ, Bishop SC, Jones DA, Haresign W, et al. (2006) Breeding programmes for TSE resistance in British sheep -I. Assessing the impact on PrP genotype frequencies. Prev Vet Med 73: 1-16.
6. Gubbins S, Roden JA (2006) Breeding programmes for TSE resistance in British sheep - II. Assessing the impact on the prevalence and incidence of scrapie. Prev Vet Med 73: 17-31.
7. Stringer SM, Hunter N, Woolhouse MEJ (1998) A mathematical model of the dynamics of scrapie in a sheep flock. Math Biosc 153: 79-98.
8. Woolhouse MEJ, Stringer SM, Matthews L, Hunter N, Anderson RM (1998) Epidemiology and control of scrapie within a flock. Proc R Soc Lond B 265: 1205-1210.
9. Woolhouse MEJ, Coen P, Matthews L, Foster J, Elsen JM, et al. (2001) A centuries-long epidemic of scrapie in British sheep? Trends Micro Biol 9(2): 67-70.
10. Sawalha RM, Brotherstone S, Conington J, Villanueva B (2007) Lambs with scrapie susceptible genotypes have higher postnatal survival. PLoS ONE 2(11): e1236. doi:10.1371/journal.pone.0001236.
11. Foster JD, Dickinson AG (1989) Age at death from natural scrapie in a flock of Suffolk sheep. Vet Rec 125: 415-417.
12. Matthews L, Coen PG, Foster JD, Hunter N, Woolhouse MEJ (2001) Population dynamics of a scrapie outbreak. Arch Virol 146: 1173-1168.
13. Lewis RM, Simm G (2000) Selection strategies in sire referencing schemes in sheep. Livest Prod Sci 67: 129-141.
14. Slate J (2005) Molecular evolution of the sheep prion protein gene. Proc R Soc B 272: 2337-2344.
15. Sawalha RM, Brotherstone S, Man WYN, Conington J, Bunger L, et al. (2007) Associations of polymorphisms of the ovine prion protein gene with growth, carcass, and computerized tomography traits in Scottish Blackface lambs. JAS 85(3): 632-640.
16. Moore RC, Boulton K, Bishop SC (2009) Associations of PrP genotype with lamb production traits in three commercial breeds of British hill sheep. Animal 3: 336-346.
17. Pritchard TC, Cahalan CM, Ap Dewi I (2008) Association between PrP gnotypes and performance traits in Welsh Maountain flock. Animal 2: 1421-1426.
18. Sweeney T, Hanrahan JP (2008) The evidence of associations between prion protein genotype and production, reproduction, and health traits in sheep. Vet Res 39(4): 28. DOI: 10.1051/vetres:2008004.
19. Gubbins S, Cook CJ, Hyder K, Boulton K, Davis C, et al. (2009) Associations between lamb survival and prion protein genotype: analysis of data for ten sheep breeds in Great Britain. BMC Vet Res 5: 3. doi:10.1186/1746-6148/5/3.
20. Lühken G, Buschmann A, Brandt H, Eiden M, Groschup MH, et al. (2007) Epidemiological and genetical differences between classical and atypical scrapie cases. Vet Res 38: 65-80.
21. Moum T, Olsaker I, Hopp P, Moldal T, Valheim M, et al. (2005) Polymorphisms at codons 141 and 154 in the ovine prion protein gene are associated with scrapie Nor98 cases. J Gen Virol 86: 231-235.
22. Hagenaars TJ, Ferguson NM, Donnelly CA, Anderson RM (2001) Persistence patterns of scrapie in a sheep flock. Epidemiol Infect 127: 157-167.
23. Hagenaars TJ, Donnelly CA, Ferguson NM, Anderson RM (2000) The transmission dynamics of the aetiological agent of scrapie in a sheep flock. Math Biosc 168: 117-135.
24. Kao RR, Gravenor MB, McLean AR (2001) Modelling the national scrapie eradication programme in the UK. Math Biosc 174: 61-76.
25. Gubbins S (2005) A modelling framework to describe the spread of scrapie between flocks in Great Britain. Prev Vet Med 67: 143-156.
26. Woolhouse MEJ, Matthews L, Coen P, Stringer SM, Foster JD, et al. (1999) Population dynamics of scrapie in a sheep flock. Proc R Soc Lond B 354: 751-756.
27. Gubbins S, Webb CR (2005) Simulation of the options for a national control programme to eradicate scrapie from Great Britain. Prev Vet Med 69: 175-187.
28. Falconer DS, Mackay TFC (1996) Introduction to quantitative genetics. 4th edn, Longman, UK.