Establishment and characterization of a cancer cell line derived from an aggressive childhood liver tumor

Pediatric Blood and Cancer

Volumn 53, Issue 6, 2009, Pages 1040-1047

  Chen, Tina T L ^a   Rakheja, Dinesh ^b   Hung, Jaclyn Y ^c   Hornsby, Peter J ^d   Tabaczewski, Piotr ^a   Malogolowkin, Marcio ^e   Feusner, James ^f   Miskevich, Frank ^g   Schultz, Roger ^b   Tomlinson, Gail E ^a,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d Mays Cancer Center at UT Health San Antonio   (United States)

^e CHILDREN S HOSPITAL LOS ANGELES   (United States)

^f CHILDREN S HOSPITAL OAKLAND   (United States)

^g TEXAS A AND M UNIVERSITY COMMERCE   (United States)

Author keywords

catenin; Alpha fetoprotein; Childhood hepatoblastoma; NOTCH2; Transitional liver cell tumor

Indexed keywords

AGAR; ALPHA FETOPROTEIN; APC PROTEIN; BETA CATENIN; CISPLATIN; FLUOROURACIL; NOTCH2 RECEPTOR; NUCLEOTIDE; PROTEIN; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MYH; PROTEINASE ACTIVATED RECEPTOR 1; UNCLASSIFIED DRUG; VINCRISTINE;

ALLELE; ANEUPLOIDY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER TISSUE; CARCINOGENESIS; CARCINOGENICITY; CASE REPORT; CAUCASIAN; CELL STRAIN HEP293TT; CHILD; CHILDHOOD CANCER; CHROMOSOME 11P; CHROMOSOME ABERRATION; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; CYTOGENETICS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE DELETION; GENE MUTATION; GENOME ANALYSIS; GENOTYPE; HEPATOBLASTOMA; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE DEFICIENCY; IMMUNOHISTOCHEMISTRY; KARYOTYPE; KIDNEY CAPSULE; LIVER DEVELOPMENT; MOLECULAR GENETICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRESCHOOL CHILD; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; SOLID TUMOR;

CELL LINE, TUMOR; CHILD; COMPARATIVE GENOMIC HYBRIDIZATION; CYTOGENETICS; GENOTYPE; HEPATOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MALE;

EID: 71049122435     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.22187     Document Type: Article

References (30)

1. Ross JA, Gurney JG. Hepatoblastoma incidence in the United States from 1973 to 1992. Med Pediatr Oncol 1998;30:141-142.
2. Oda H, Imai Y, Nakatsuru Y, et al. Somatic mutations of the APC gene in sporadic hepatoblastomas. Cancer Res 1996;56:3320-3323. (Pubitemid 26242983)
3. Kurahashi H, Takami K, Oue T, et al. Biallelic inactivation of the APC gene in hepatoblastoma. Cancer Res 1995;55:5007-5011.
4. Koch A, Denkhaus D, Albrecht S, et al. Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene. Cancer Res 1999;59:269-273. (Pubitemid 29048850)
5. Giardiello FM, Petersen GM, Brensinger JD, et al. Hepatoblastoma and APC gene mutation in familial adenomatous polyposis. Gut 1996;39:867-869. (Pubitemid 27049093)
6. Aretz S, Koch A, Uhlhaas S, et al. Should children at risk for familial adenomatous polyposis be screened for hepatoblastoma and children with apparently sporadic hepatoblastoma be screened for APC germline mutations? Pediatr Blood Cancer 2006;47:811-818.
7. Hirschman BA, Pollock BH, Tomlinson GE. The spectrum of APC mutations in children with hepatoblastoma from familial adenomatous polyposis kindreds. J Pediatr 2005;147:263-266. (Pubitemid 41207846)
8. Curia MC, Zuckermann M, De Lellis L, et al. Sporadic childhood hepatoblastomas show activation of beta-catenin, mismatch repair defects and p53 mutations. Mod Pathol 2008;21:7-14.
9. Fukuzawa R, Hata J, Hayashi Y, et al. Beckwith-Wiedemann syndrome-associated hepatoblastoma: Wnt signal activation occurs later in tumorigenesis in patients with 11p15.5 uniparental disomy. Pediatr Dev Pathol 2003;6:299-306. (Pubitemid 37174831)
10. Hamada Y, Takada K, Fukunaga S, et al. Hepatoblastoma associated with Beckwith-Wiedemann syndrome and hemihypertrophy. Pediatr Surg Int 2003;19:112-114. (Pubitemid 36717315)
11. Little MH, Thomson DB, Hayward NK, et al. Loss of alleles on the short arm of chromosome 11 in a hepatoblastoma from a child with Beckwith-Wiedemann syndrome. Hum Genet 1988;79:186-189. (Pubitemid 18179546)
12. Kubota M, Yagi M, Kanada S, et al. Effect of postoperative chemotherapy on the serum alpha-fetoprotein level in hepatoblastoma. J Pediatr Surg 2004;39:1775-1778. (Pubitemid 40017713)
13. Sayar D, Yaniv I, Goshen Y, et al. Treatment of alpha-fetoprotein secreting hepatoblastoma by response of serum alpha-fetoprotein levels: A new concept. Pediatr Hematol Oncol 2001;18:509-518. (Pubitemid 33108273)
14. Van Tornout JM, Buckley JD, Quinn JJ, et al. Timing and magnitude of decline in alpha-fetoprotein levels in treated children with unresectable or metastatic hepatoblastoma are predictors of outcome: A report from the Children's Cancer Group. J Clin Oncol 1997;15:1190-1197.
15. Sato M, Vaughan MB, Girard L, et al. Multiple oncogenic changes (K-RAS(V12), p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells. Cancer Res 2006;66:2116-2128. (Pubitemid 43294921)
16. Sun B, Chen M, Hawks CL, et al. The minimal set of genetic alterations required for conversion of primary human fibroblasts to cancer cells in the subrenal capsule assay. Neoplasia 2005;7:585-593. (Pubitemid 40967759)
17. Lins AM, Micka KA, Sprecher CJ, et al. Development and population study of an eight-locus short tandem repeat (STR) multiplex system. J Forensic Sci 1998;43:1168-1180. (Pubitemid 28554814)
18. Selzer RR, Richmond TA, Pofahl NJ, et al. Analysis of chromosome breakpoints in neuroblastoma at sub-kilobase resolution using fine-tiling oligonucleotide array CGH. Genes Chromosomes Cancer 2005;44:305-319.
19. Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: Cell fate control and signal integration in development. Science 1999; 284:770-776. (Pubitemid 29291335)
20. Tomlinson GE, Douglass EC, Pollock BH, et al. Cytogenetic evaluation of a large series of hepatoblastomas: Numerical abnormalities with recurring aberrations involving 1q12-q21. Genes Chromosomes Cancer 2005;44:177-184.
21. Fuchs J, Schmidt D, Pietsch T, et al. Successful transplantation of human hepatoblastoma into immunodeficient mice. J Pediatr Surg 1996;31:1241-1246. (Pubitemid 26313780)
22. Aden DP, Fogel A, Plotkin S, et al. Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. Nature 1979;282:615-616. (Pubitemid 10213918)
23. Pietsch T, Fonatsch C, Albrecht S, et al. Characterization of the continuous cell line HepT1 derived from a human hepatoblastoma. Lab Invest 1996;74:809-818. (Pubitemid 26117140)
24. Weber RG, Pietsch T, von Schweinitz D, et al. Characterization of genomic alterations in hepatoblastomas. A role for gains on chromosomes 8q and 20 as predictors of poor outcome. Am J Pathol 2000;157:571-578. (Pubitemid 30627562)
25. Doi I. Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma. Gann 1976;67:1-10.
26. Scheil S, Hagen S, Bruderlein S, et al. Two novel in vitro human hepatoblastoma models, HepU1 and HepU2, are highly characteristic of fetal-embryonal differentiation in hepatoblastoma. Int J Cancer 2003;105:347-352. (Pubitemid 36570047)
27. Lozier J, McCright B, Gridley T. Notch signaling regulates bile duct morphogenesis in mice. PLoS ONE 2008;3:e1851. (Pubitemid 351936463)
28. Loomes KM, Taichman DB, Glover CL, et al. Characterization of Notch receptor expression in the developing mammalian heart and liver. Am J Med Genet 2002;112:181-189. (Pubitemid 35332184)
29. Prokurat A, Kluge P, Kosciesza A, et al. Transitional liver cell tumors (TLCT) in older children and adolescents: Anovel group of aggressive hepatic tumors expressing beta-catenin. Med Pediatr Oncol 2002;39:510-518.
30. Yamaoka H, Ohtsu K, Sueda T, et al. Diagnostic and prognostic impact of beta-catenin alterations in pediatric liver tumors. Oncol Rep 2006;15:551-556.