Characterization of genomic alterations in hepatoblastomas: A role for gains on chromosomes 8q and 20 as predictors of poor outcome

American Journal of Pathology

Volumn 157, Issue 2, 2000, Pages 571-578

  Weber, Ruthild G ^a   Pietsch, Torsten ^b   Von Schweinitz, Dietrich ^c   Lichter, Peter ^d  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF BONN   (Germany)

^d UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL LINE; CHILD; CHROMOSOME 20; CHROMOSOME 2Q; CHROMOSOME 8Q; CLINICAL ARTICLE; FEMALE; GENE AMPLIFICATION; GENE MUTATION; HEPATOBLASTOMA; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; INFANT; MALE; PRIORITY JOURNAL; PROGNOSIS;

EID: 0033900096     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64567-1     Document Type: Article

References (54)

1. Cancer incidence, survival, and mortality for children younger than age 15 years
2. Hepatoblastoma and hepatocarcinoma in infancy and childhood. Report of 47 cases
3. Primary hepatic tumors of childhood
4. Hepatitis B virus. The major etiology of hepatocellular carcinoma
5. Risk of cancer during the first four years of life in children from the Beckwith-Wiedemann syndrome registry
6. Risk of hepatoblastoma in familial adenomatous polyposis
7. Loss of heterozygosity in three embryonal tumors suggests a common pathogenetic mechanism
8. Loss of maternal alleles on chromosome arm 11p in hepatoblastoma
9. Somatic mutations of the APC gene in sporadic hepatoblastomas
10. Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the section-catenin gene
11. Hepatoblastoma characterized by trisomy 20 and double minutes
12. Consistent cytogenetic aberrations in hepatoblastoma: A common pathway of genetic alterations in embryonal liver and skeletal muscle malignancies?
13. Trisomy 2 and 20 in two hepatoblastomas
14. Chromosome aberrations in an alpha-fetoprotein-producing hepatoblastoma
15. Trisomy 2 as the sole chromosomal abnormality in a hepatoblastoma
16. Trisomy 2, trisomy 20, and del(17p) as sole chromosomal abnormalities in three cases of hepatoblastoma
17. Significance of extra copies of chromosome 20 and the long arm of chromosome 2 in hepatoblastoma
18. Cytogenetic abnormalities and clonal evolution in an adult hepatoblastoma
19. The first recurring chromosome translocation in hepatoblastoma: Der(4)t(1;4)(q12;q34)
20. Fluorescence in situ hybridization reveals trisomy 2q by insertion into 9p in hepatoblastoma
21. Cytogenetic analysis of hepatoblastoma: Hypothesis of cytogenetic evolution in such tumors and results of a multicentric study
22. Karyotypic analyses of hepatoblastoma. Report of two cases and review of the literature suggesting chromosomal loci responsible for the pathogenesis of this disease
23. Characterization of the continuous cell line HepT1 derived from a human hepatoblastoma
24. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors
25. Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization
26. Loss of heterozygosity on chromosome 1 in human hepatoblastoma
27. Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma
28. Efficiency and toxicity of ifosfamide, cisplatin and doxorubicin in the treatment of childhood hepatoblastoma
29. Delection of chromosomal aberrations by means of molecular cytogenetics: Painting of chromosomes and chromosomal subregions and comparative genomic hybridization
30. Quantitative analysis of comparative genomic hybridization
31. Minimal size of deletions detected by comparative genomic hybridization
32. Detection of amplified genomic sequences by reverse chromosome painting using genomic tumor DNA as probe
33. Computer image analysis of comparative genomic hybridization
34. Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors
35. Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: Toward a genetic model of meningioma progression
36. Comparative genomic hybridization analysis of hepatoblastomas: Additional evidence for a genetic link with Wilms tumor and rhabdomyosarcoma
37. Comparative genomic hybridization analysis of hepatoblastomas
38. Genetic changes in inherited and sporadic ovarian carcinomas by comparative genomic hybridization: Extensive similarity except for a difference at chromosome 2q24-q32
39. Chromosomal analysis of sixteen human rhabdomyosarcomas
40. Chromosome 2 abnormalities (+Der 2) in two cases of childhood rhabdomyosarcoma
41. Gains, losses, and amplification of genomic material in rhabdomyosarcoma analyzed by comparative genomic hybridization
42. Comparative genomic hybridization analysis of Wilms tumors
43. Comparative genomic hybridization and its application to Wilms' tumorigenesis
44. Genetic analysis of ovarian germ cell tumors by comparative genomic hybridization
45. Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis
46. Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization
47. Molecular genetics of Wiedemann-Beckwith syndrome
48. Retrospective study on amplification of N-myc and c-myc genes in pediatric solid tumors and its association with prognosis and tumor differentiation
49. Oncogene amplification and expression in pediatric solid tumors
50. Hepatoblastoma in families with polyposis coli
51. Hepatoblastoma and APC gene mutation in familial adenomatous polyposis
52. Identification of a 1-cM region of common deletion on 4q35 associated with progression of hepatocellular carcinoma
53. Prognostic factors and staging systems in childhood hepatoblastoma