The Pneumocystis meiotic PCRan1p kinase exhibits unique temperature-regulated activity

American Journal of Respiratory Cell and Molecular Biology

Volumn 41, Issue 6, 2009, Pages 714-721

  Burgess, Joshua W ^a,b   Kottom, Theodore J ^a,b   Villegas, Leah R ^a,b   Lamont, Jeffrey D ^a,b   Baden, Elizabeth M ^b   Ramirez Alvarado, Marina ^b   Limper, Andrew H ^a,b  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

Kinase; Meiosis; Pneumocystis; Temperature

Indexed keywords

FUNGAL PROTEIN; METAL ION; PAT1 KINASE; PCRAN1 KINASE; PHOSPHOTRANSFERASE; PROTEIN PCCBK1; PROTEIN PCSTE20; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; ENZYME ACTIVITY; ESCHERICHIA COLI; EX VIVO STUDY; FLUORESCENCE SPECTROSCOPY; IN VITRO STUDY; MEIOSIS; NONHUMAN; PH; PNEUMOCYSTIS CARINII; PNEUMONIA; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SACCHAROMYCES CEREVISIAE; TEMPERATURE;

BASE SEQUENCE; CIRCULAR DICHROISM; DNA PRIMERS; FUNGAL PROTEINS; MEIOSIS; PNEUMOCYSTIS CARINII; PROTEIN DENATURATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SPECIES SPECIFICITY; SPECTROMETRY, FLUORESCENCE; TEMPERATURE;

ESCHERICHIA COLI; MAMMALIA; PNEUMOCYSTIS; PNEUMOCYSTIS CARINII; SACCHAROMYCES CEREVISIAE;

EID: 70949107672     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2008-0098OC     Document Type: Article

References (29)

1. Limper AH, Offord KP, Smith TF, Martin WJ II. Pneumocystis carinii pneumonia: differences in lung parasite number and inflammation in patients with and without AIDS. Am Rev Respir Dis 1989;140:1204-1209.
2. Thomas CF Jr, Limper AH. Current insights into the biology and pathogenesis of Pneumocystis pneumonia. Nat Rev Microbiol 2007;5:298-308. (Pubitemid 46443606)
3. Wakefield AE, Lindley AR, Ambrose HE, Denis CM, Miller RF. Limited asymptomatic carriage of Pneumocystis jiroveci in human immunodeficiency virus-infected patients. J Infect Dis 2003;187:901-908.
4. Larsen HH, von Linstow ML, Lundgren B, Hogh B, Westh H, Lundgren JD. Primary Pneumocystis infection in infants hospitalized with acute respiratory tract infection. Emerg Infect Dis 2007;13:66-72. (Pubitemid 46057839)
5. Morris A, Beard CB, Huang L. Update on the epidemiology and transmission of Pneumocystis carinii. Microbes Infect 2002;4:95-103. (Pubitemid 34127996)
6. Cushion MT, Beck JM. Summary of Pneumocystis research presented at the 7th international workshop on opportunistic protists. J Eukaryot Microbiol 2001:101S-105S.
7. Matsumoto Y, Yoshida Y. Sporogony in Pneumocystis carinii: synaptonemal complexes and meiotic nuclear divisions observed in precysts. J Protozool 1984;31:420-428. (Pubitemid 14020763)
8. Haidaris PJ, Wright TW, Gigliotti F, Fallon MA, Whitbeck AA, Haidaris CG. In situ hybridization analysis of developmental stages of Pneumocystis carinii that are transcriptionally active for a major surface glycoprotein gene. Mol Microbiol 1993;7:647-656.
9. Itatani CA, Marshall GJ. Ultrastructural morphology and staining characteristics of Pneumocystis carinii in situ and from bronchoalveolar lavage. J Parasitol 1988;74:700-712. (Pubitemid 18192346)
10. Burgess JW, Kottom TJ, Limper AH. Pneumocystis carinii exhibits a conserved meiotic control pathway. Infect Immun 2008;76:417-425.
11. Kottom TJ, Kohler JR, Thomas CF Jr, Fink GR, Limper AH. Lung epithelial cells and extracellular matrix components induce expression of Pneumocystis carinii Ste20, a gene complementing the mating and pseudohyphal growth defects of Ste20 mutant yeast. Infect Immun 2003;71:6463-6471.
12. Kottom TJ, Limper AH. Pneumocystis carinii cell wall biosynthesis kinase gene Cbk1 is an environmentally responsive gene that complements cell wall defects of Cbk-deficient yeast. Infect Immun 2004;72:4628-4636.
13. 1+ controls the transition from mitotic division to meiosis in fission yeast. Curr Genet 1985;10:297-311.
14. Iino Y, Yamamoto M. Negative control for the initiation of meiosis in Schizosaccharomyces pombe. Proc Natl Acad Sci USA 1985;82:2447-2451. (Pubitemid 15071285)
15. Watanabe Y, Shinozaki-Yabana S, Chikashige Y, Hiraoka Y, Yamamoto M. Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast. Nature 1997;386:187-190. (Pubitemid 27131447)
16. Leberer E, Ziegelbauer K, Schmidt A, Harcus D, Dignard D, Ash J, Johnson L, Thomas DY. Virulence and hyphal formation of Candida albicans require the Ste20p-like protein kinase CaCla4p. Curr Biol 1997;7:539-546. (Pubitemid 27335648)
17. Bidlingmaier S, Weiss EL, Seidel C, Drubin DG, Snyder M. The Cbk1p pathway is important for polarized cell growth and cell separation in Saccharomyces cerevisiae. Mol Cell Biol 2001;21:2449-2462. (Pubitemid 32222097)
18. Colman-Lerner A, Chin TE, Brent R. Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates. Cell 2001;107:739-750. (Pubitemid 34033667)
19. McNemar MD, Fonzi WA. Conserved serine/threonine kinase encoded by Cbk1 regulates expression of several hypha-associated transcripts and genes encoding cell wall proteins in Candida albicans. J Bacteriol 2002;184:2058-2061.
20. Kottom TJ, Thomas CF Jr, Mubarak KK, Leof EB, Limper AH. Pneumocystis carinii uses a functional Cdc13 B-type cyclin complex during its life cycle. Am J Respir Cell Mol Biol 2000;22:722-731.
21. Hahn PY, Evans SE, Kottom TJ, Standing JE, Pagano RE, Limper AH. Pneumocystis carinii cell wall beta-glucan induces release of macrophage inflammatory protein-2 from alveolar epithelial cells via a lactosylceramide- mediated mechanism. J Biol Chem 2003;278:2043-2050.
22. Kottom TJ, Thomas CF Jr, Limper AH. Characterization of Pneumocystis carinii Phr1, a pH-regulated gene important for cell wall integrity. J Bacteriol 2001;183:6740-6745.
23. Thomas CF, Anders RA, Gustafson MP, Leof EB, Limper AH. Pneumocystis carinii contains a functional cell-division-cycle Cdc2 homologue. Am J Respir Cell Mol Biol 1998;18:297-306.
24. Vohra PK, Puri V, Kottom TJ, Limper AH, Thomas CF Jr. Pneumocystis carinii Ste11, an Hmg-BOX protein, is phosphorylated by the mitogen activated protein kinase Pcm. Gene 2003;312:173-179. (Pubitemid 37338122)
25. Icenhour CR, Rebholz SL, Collins MS, Cushion MT. Early acquisition of Pneumocystis carinii in neonatal rats using targeted PCR and oral swabs. J Eukaryot Microbiol 2001;135S-136S.
26. Wyder MA, Rasch EM, Kaneshiro ES. Quantitation of absolute Pneumocystis carinii nuclear DNA content: trophic and cystic forms isolated from infected rat lungs are haploid organisms. J Eukaryot Microbiol 1998;45:233-239.
27. Pande AH, Scaglione P, Taylor M, Nemec KN, Tuthill S, Moe D, Holmes RK, Tatulian SA, Teter K. Conformational instability of the cholera toxin A1 polypeptide. J Mol Biol 2007;374:1114-1128. (Pubitemid 350052108)
28. Watanabe Y, Yamamoto MS. Pombe mei2+ encodes an RNA-binding protein essential for premeiotic DNA synthesis and meiosis I, which cooperates with a novel RNA species meiRNA. Cell 1994;78:487-498. (Pubitemid 24250812)
29. 1+ protein kinase regulates entry intomeiosis in Schizosaccharomycespombe. Nature 1988;332:509-514.