Pneumocystis carinii STE11, an HMG-box protein, is phosphorylated by the mitogen activated protein kinase PCM

Gene

Volumn 312, Issue 1-2, 2003, Pages 173-179

  Vohra, Pawan K ^a   Puri, Veenu ^a   Kottom, Theodore J ^a   Limper, Andrew H ^a   Thomas Jr , Charles F ^a  

^a MAYO CLINIC   (United States)

Author keywords

Acquired immunodeficiency syndrome (AIDS); HMG box protein; Mitogen activated protein kinase (MAPK); STE11; Transcription

Indexed keywords

AMINO ACID; FUNGAL ENZYME; FUNGAL PROTEIN; HISTAMINE; MITOGEN ACTIVATED PROTEIN KINASE; NICKEL; PHEROMONE; RESIN; TRANSCRIPTION FACTOR; COMPLEMENTARY DNA; HIGH MOBILITY GROUP B PROTEIN; RECOMBINANT PROTEIN; STE11 PROTEIN, PNEUMOCYSTIS CARINII;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOWNSTREAM PROCESSING; FUNGAL GENETICS; FUNGAL STRAIN; FUNGUS GROWTH; GENETIC CODE; HOMEOBOX; HORMONE BINDING; HORMONE SYNTHESIS; INTERMEDIATE FILAMENT; MOLECULAR CLONING; MOLECULAR INTERACTION; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PATHOGENICITY; PNEUMOCYSTIS CARINII; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; RAT; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SEQUENCE HOMOLOGY; SEXUAL DEVELOPMENT; STATISTICAL SIGNIFICANCE; TRANSCRIPTION INITIATION; AMINO ACID SEQUENCE; CHEMISTRY; DNA SEQUENCE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; PNEUMOCYSTIS; POLYACRYLAMIDE GEL ELECTROPHORESIS; SEQUENCE ALIGNMENT;

FUNGI; PNEUMOCYSTIS CARINII; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE;

AMINO ACID SEQUENCE; BASE SEQUENCE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HMGB PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PNEUMOCYSTIS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION, GENETIC;

EID: 0141541802     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(03)00614-0     Document Type: Article

References (29)

1. Bardwell L., Cook J.G., Voora D., Baggott D.M., Martinez A.R., Thorner J. Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK. Genes Dev. 12:1998;2887-2898.
2. Bartlett M.S., Fishman J.A., Queener S.F., Durkin M.M., Jay M.A., Smith J.W. New rat model of Pneumocystis carinii infection. J. Clin. Microbiol. 26:1988;1100-1102.
3. Chang Y.C., Penoyer L.A., Kwon-Chung K.J. The second STE12 homologue of Cryptococcus neoformans is MATa-specific and plays an important role in virulence. Proc. Natl. Acad. Sci. USA. 98:2001;3258-3263.
4. Cook J.G., Bardwell L., Thorner J. Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous-growth signalling pathway. Nature. 390:1997;85-88.
5. Cushion M.T., Beck J.M. Summary of Pneumocystis research presented at the 7th International Workshop on Opportunistic Protists. J. Eukaryot. Microbiol. 2001;101S-105S.
6. Dolan J.W., Fields S. Overproduction of the yeast STE12 protein leads to constitutive transcriptional induction. Genes Dev. 4:1990;492-502.
7. Dolan J.W., Kirkman C., Fields S. The yeast STE12 protein binds to the DNA sequence mediating pheromone induction. Proc. Natl. Acad. Sci. USA. 86:1989;5703-5707.
8. Elion E.A., Satterberg B., Kranz J.E. FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1. Mol. Biol. Cell. 4:1993;495-510.
9. Errede B., Ammerer G. STE12, a protein involved in cell-type-specific transcription and signal transduction in yeast, is part of protein-DNA complexes. Genes Dev. 3:1989;1349-1361.
10. Filice G., Carnevale G., Lanzarini P., Castelli F., Olliaro P., Orsolini P., Carosi G., Rondanelli E.G. Life cycle of P. carinii in the lung of immuno-compromised hosts: an ultrastructural study. Microbiologica. 8:1985;319-328.
11. Gustafson M.P., Thomas C.F. Jr, Rusnak F., Limper A.H., Leof E.B. Differential regulation of growth and checkpoint control mediated by a Cdc25 mitotic phosphatase from Pneumocystis carinii. J. Biol. Chem. 276:2001;835-843.
12. Haidaris P.J., Wright T.W., Gigliotti F., Fallon M.A., Whitbeck A.A., Haidaris C.G. In situ hybridization analysis of developmental stages of Pneumocystis carinii that are transcriptionally active for a major surface glycoprotein gene. Mol. Microbiol. 7:1993;647-656.
13. Hartmann H.A., Kahmann R., Bolker M. The pheromone response factor coordinates filamentous growth and pathogenicity in Ustilago maydis. EMBO J. 15:1996;1632-1641.
14. Hartwell L.H. Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone. J. Cell. Biol. 85:1980;811-822.
15. Hung W., Olson K.A., Breitkreutz A., Sadowski I. Characterization of the basal and pheromone-stimulated phosphorylation states of Ste12p. Eur. J. Biochem. 245:1997;241-251.
16. Kottom T.J., Thomas C.F. Jr, Limper A.H. Characterization of Pneumocystis carinii PHR1, a pH-regulated gene important for cell wall Integrity. J. Bacteriol. 183:2001;6740-6745.
17. Kottom T.J., Thomas C.F. Jr, Mubarak K.K., Leof E.B., Limper A.H. Pneumocystis carinii uses a functional cdc13 B-type cyclin complex during its life cycle. Am. J. Respir. Cell. Mol. Biol. 22:2000;722-731.
18. Kutty G., Kovacs J.A. A Single-Copy Gene Encodes Kex1, a Serine Endoprotease of Pneumocystis jiroveci. Infect. Immun. 71:2003;571-574.
19. Limper A.H., Offord K.P., Smith T.F., Martin W.J. 2nd. Pneumocystis carinii pneumonia. Differences in lung parasite number and inflammation in patients with and without AIDS. Am. Rev. Respir. Dis. 140:1989;1204-1209.
20. Madhani H.D., Styles C.A., Fink G.R. MAP kinases with distinct inhibitory functions impart signaling specificity during yeast differentiation. Cell. 91:1997;673-684.
21. Oehlen B., Cross F.R. Signal transduction in the budding yeast Saccharomyces cerevisiae. Curr. Opin. Cell Biol. 6:1994;836-841.
22. Sengupta P., Cochran B.H. The PRE and PQ box are functionally distinct yeast pheromone response elements. Mol. Cell Biol. 10:1990;6809-6812.
23. Song D., Dolan J.W., Yuan Y.L., Fields S. Pheromone-dependent phosphorylation of the yeast STE12 protein correlates with transcriptional activation. Genes Dev. 5:1991;741-750.
24. Sugimoto A., Iino Y., Maeda T., Watanabe Y., Yamamoto M. Schizosaccharomyces pombe ste11+ encodes a transcription factor with an HMG motif that is a critical regulator of sexual development. Genes Dev. 5:1991;1990-1999.
25. Thomas C.F., Anders R.A., Gustafson M.P., Leof E.B., Limper A.H. Pneumocystis carinii contains a functional cell-division-cycle Cdc2 homologue. Am. J. Respir. Cell. Mol. Biol. 18:1998;297-306.
26. Thomas C.F. Jr, Kottom T.J., Leof E.B., Limper A.H. Characterization of a mitogen-activated protein kinase from Pneumocystis carinii. Am. J. Physiol. 275:1998;L193-L199.
27. Thomas C.F. Jr, Limper A.H. Pneumocystis pneumonia: clinical presentation and diagnosis in patients with and without acquired immune deficiency syndrome. Semin. Respir. Infect. 13:1998;289-295.
28. Yuan Y.L., Fields S. Properties of the DNA-binding domain of the Saccharomyces cerevisiae STE12 protein. Mol. Cell Biol. 11:1991;5910-5918.
29. Yue C., Cavallo L.M., Alspaugh J.A., Wang P., Cox G.M., Perfect J.R., Heitman J. The STE12alpha homolog is required for haploid filamentation but largely dispensable for mating and virulence in Cryptococcus neoformans. Genetics. 153:1999;1601-1615.