A cell motility screen reveals role for MARCKS-related protein in adherens junction formation and tumorigenesis

PLoS ONE

Volumn 4, Issue 11, 2009, Pages

  Finlayson, Alexander E ^a   Freeman, Kevin W ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; MARCKS PROTEIN; T CELL FACTOR PROTEIN; TRIFLUOPERAZINE; UVOMORULIN; WNT3A PROTEIN; CADHERIN; MARCKSL1 PROTEIN, HUMAN; MEMBRANE PROTEIN; MICRORNA; MIRN21 MICRORNA, HUMAN;

ANTIGEN PRESENTING CELL; ARTICLE; CANCER CELL; CANCER INVASION; CARCINOGENESIS; CELL ADHESION; CELL CONTACT; CELL JUNCTION; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; GENE EXPRESSION; GENE LOCATION; GENE TARGETING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; PROSTATE CANCER; REPORTER GENE; SIGNAL TRANSDUCTION; TIGHT JUNCTION; WOUND HEALING; CELL COMMUNICATION; CELL MOTION; CELL TRANSFORMATION; FLUORESCENCE MICROSCOPY; METABOLISM; METASTASIS; METHODOLOGY; TUMOR CELL LINE;

ADHERENS JUNCTIONS; BETA CATENIN; CADHERINS; CELL COMMUNICATION; CELL LINE, TUMOR; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; MEMBRANE PROTEINS; MICRORNAS; MICROSCOPY, FLUORESCENCE; NEOPLASM METASTASIS; SIGNAL TRANSDUCTION; WOUND HEALING;

EID: 70849127012     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007833     Document Type: Article

References (27)

1. Wolf K, Mazo I, Leung H, Engelke K, von Andrian UH, et al. (2003) Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol 160(2): 267-277.
2. Sahai E, Marshall CJ (2003) Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol 5(8): 711-719.
3. Sodek KL, Brown TJ, Ringuette MJ (2008) Collagen I but not Matrigel matrices provide an MMP-dependent barrier to ovarian cancer cell penetration. BMC cancer 8: 223.
4. Gimona M, Buccione R, Courtneidge SA, Linder S (2008) Assembly and biological role of podosomes and invadopodia. Curr Opin Cell Biol 20(2): 235-241.
5. Ramsden JJ (2000) MARCKS: a case of molecular exaptation? Int J Biochem Cell Biol 32(5): 475-479.
6. Verghese GM, Johnson JD, Vasulka C, Haupt DM, Stumpo DJ, et al. (1994) Protein kinase C-mediated phosphorylation and calmodulin binding of recombinant myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein. The Journal of biological chemistry 269(12): 9361-9367.
7. Porumb T, Crivici A, Blackshear PJ, Ikura M (1997) Calcium binding and conformational properties of calmodulin complexed with peptides derived from myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP). Eur Biophys J 25(4): 239-247.
8. McLaughlin S, Hangyas-Mihalyne G, Zaitseva I, Golebiewska U (2005) Reversible - through calmodulin - electrostatic interactions between basic residues on proteins and acidic lipids in the plasma membrane. Biochem Soc Symp(72): 189-198.
9. Arbuzova A, Schmitz AA, Vergeres G (2002) Cross-talk unfolded: MARCKS proteins. Biochem J 362(Pt 1): 1-12.
10. Chang S, Hemmings HC, Jr., Aderem A (1996) Stimulus-dependent phosphorylation of MacMARCKS, a protein kinase C substrate, in nerve termini and PC12 cells. The Journal of biological chemistry 271(2): 1174-1178.
11. Wang J, Arbuzova A, Hangyas-Mihalyne G, McLaughlin S (2001) The l phosphatidylinositol 4,5-bisphosphate. The Journal of biological chemistry 276(7): 5012-5019.
12. Li T, Li D, Sha J, Sun P, Huang Y (2009) MicroRNA-21 directly targets MARCKS and promotes apoptosis resistance and invasion in prostate cancer cells. Biochemical and biophysical research communications 383(3): 280-285.
13. Michaelson JS, Leder P (2001) beta-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland. Oncogene 20(37): 5093-5099.
14. Koh EY, Chen T, Daley GQ (2002) Novel retroviral vectors to facilitate expression screens in mammalian cells. Nucleic Acids Res 30(24): e142.
15. Friedl P, Gilmour D (2009) Collective cell migration in morphogenesis, regeneration and cancer. Nature reviews 10(7): 445-457.
16. Bidard FC, Pierga JY, Vincent-Salomon A, Poupon MF (2008) A "class action" against the microenvironment: do cancer cells cooperate in metastasis? Cancer metastasis reviews 27(1): 5-10.
17. Christiansen JJ, Rajasekaran AK (2006) Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer research 66(17): 8319-8326.
18. Sengupta P, Ruano MJ, Tebar F, Golebiewska U, Zaitseva I, et al. (2007) Membrane-permeable calmodulin inhibitors (e.g. W-7/W-13) bind to membranes, changing the electrostatic surface potential: dual effect of W-13 on epidermal growth factor receptor activation. The Journal of biological chemistry 282(11): 8474-8486.
19. Willert K, Jones KA (2006) Wnt signaling: is the party in the nucleus? Genes & development 20(11): 1394-1404.
20. Brown MD, Sacks DB (2006) IQGAP1 in cellular signaling: bridging the GAP. Trends Cell Biol 16(5): 242-249.
21. Noritake J, Fukata M, Sato K, Nakagawa M, Watanabe T, et al. (2004) Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact. Mol Biol Cell 15(3): 1065-1076.
22. Pilot F, Philippe JM, Lemmers C, Lecuit T (2006) Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz. Nature 442(7102): 580-584.
23. Faux MC, Ross JL, Meeker C, Johns T, Ji H, et al. (2004) Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion. J Cell Sci 117(Pt 3): 427-439.
24. Lallemand D, Curto M, Saotome I, Giovannini M, McClatchey AI (2003) NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes & development 17(9): 1090-1100.
25. Wicki A, Christofori G (2007) The potential role of podoplanin in tumour invasion. British journal of cancer 96(1): 1-5.
26. Wicki A, Lehembre F, Wick N, Hantusch B, Kerjaschki D, et al. (2006) Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer cell 9(4): 261-272.
27. Macpherson IR, Hooper S, Serrels A, McGarry L, Ozanne BW, et al. (2007) p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism. Oncogene 26(36): 5214-5228.