Synthesis of heterosteroids. First synthesis of oxa steroid from cholic acid

Tetrahedron Letters

Volumn 51, Issue 1, 2010, Pages 93-95

  Ibrahim Ouali, Malika ^a   Botsi Nkomendi, Nicaise ^a   Rocheblave, Luc ^b  

^a AIX MARSEILLE UNIVERSITÉ   (France)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

Baeyer Villiger oxidation; Cholic acid; Microwave; Oxa steroid; Photolysis

Indexed keywords

3 OXA 5BETA STEROID; CHOLIC ACID; STEROID; UNCLASSIFIED DRUG;

ARTICLE; BAEYER VILLIGER REACTION; DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 70849116683     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2009.10.141     Document Type: Article

References (20)

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17. To our knowledge, no successful formation of lactones from cholic acid has been previously reported and this seems to be the first example.
18. 2/MeOH; 95:5) to afford lactone 9 (0.4 g, 75%).
19. +]; found: 422.3400.
20. The intermediates compounds 6-11 in the synthesis of 12 are all new products, their structures were confirmed by spectroscopic methods and will be reported in due course.