Combination strategy to increase cyclosporin A productivity by Tolypocladium niveum using random mutagenesis and protoplast transformation

Journal of Microbiology and Biotechnology

Volumn 19, Issue 9, 2009, Pages 869-872

  Lee, Mi Jin ^a   Duong, Cac Thi Phung ^a   Han, Kyuboem ^b   Kim, Eung Soo ^a  

^a Inha University   (South Korea)

^b Hanson Biotech Co Ltd   (South Korea)

Author keywords

Cyclosporin A; Mutagenesis; Protoplast transformation; Tolypocladium niveum

Indexed keywords

CYCLOSPORIN A;

ARTICLE; ASCOMYCETES; DRUG SYNTHESIS; FUNGAL METABOLISM; FUNGAL STRAIN; METABOLITE; MUTAGENESIS; NONHUMAN; PRODUCTIVITY; PROTOPLAST; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOLYPOCLADIUM NIVEUM; ULTRAVIOLET IRRADIATION; WILD TYPE;

BACTERIAL PROTEINS; CYCLOSPORINE; GENES, BACTERIAL; HYPOCREALES; MUTAGENESIS; PROTOPLASTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC; TRUNCATED HEMOGLOBINS; VITREOSCILLA;

BACTERIA (MICROORGANISMS); FUNGI; TOLYPOCLADIUM INFLATUM; VITREOSCILLA;

EID: 70849109003     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: 10.4014/jmb.0811.629     Document Type: Article

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