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The diastereomers were separable by chromatography, allowing isolation of the major adduct with the yields reported in Table 2. It was possible to isolate also the cis isomer of compounds 11-15.
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70749152961
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note
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This high selectivity can be explained with the higher lability of the bond on C8a due to the presence of the carbonyl. This situation allows a rapid equilibration toward the trans isomer even in the presence of small amounts of acid .
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38
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70749138967
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See Supporting Information for ORTEP of 27
-
See Supporting Information for ORTEP of 27.
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39
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70749153787
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WO 2004092166 A2 20041028. Knaup, G. DE 10020818 Al 20011031
-
3-Aminoazepanones substituted in position 7 have been previously described in several patents as structures of pharmaceutic interest. See for example: Burgey, C. S.; Deng, Z. J.; Nguyen, D. N.; Paone, D. L. V.; Shaw, A. W.; Williams, T. M. WO 2004092166 A2 20041028. Knaup, G. DE 10020818 Al 20011031
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40
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67149089291
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