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Volumn 11, Issue 22, 2009, Pages 5314-5317

Four-component reactions toward fused heterocyclic rings

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; CARBOXYLIC ACID; HETEROCYCLIC COMPOUND; HYDROGEN; IMINE;

EID: 70749143083     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol902279m     Document Type: Article
Times cited : (42)

References (40)
  • 6
    • 0028757621 scopus 로고
    • Multicomponent reactions in organic chemistry
    • (a) Ugi, I.; Domling, A.; Horl, W. Multicomponent reactions in organic chemistry. Endeavour 1994, 18, 115-122.
    • (1994) Endeavour , vol.18 , pp. 115-122
    • Ugi, I.1    Domling, A.2    Horl, W.3
  • 12
  • 13
    • 65249100749 scopus 로고    scopus 로고
    • For an interesting overview on the need for innovation in multicomponent reactions, see: Ganem, B. Acc. Chem. Res. 2009, 42, 463-472.
    • (2009) Acc. Chem. Res. , vol.42 , pp. 463-472
    • Ganem, B.1
  • 22
    • 0025992651 scopus 로고
    • For leading references on chiral non-racemic bicyclic lactams, see: (a) Romo, D.; Meyers, A. I. Tetrahedron 1991, 47, 9503-9569.
    • (1991) Tetrahedron , vol.47 , pp. 9503-9569
    • Romo, D.1    Meyers, A.I.2
  • 32
    • 84906480117 scopus 로고    scopus 로고
    • Katritzky, A. R., Ramsden, C. A., Scriven, E. F. V., Taylor, R. J., Eds.; Elsevier Ltd.: Oxford
    • Couty, F.; Evano, G. In Comprehensive Heterocyclic Chemistry III; Katritzky, A. R., Ramsden, C. A., Scriven, E. F. V., Taylor, R. J., Eds.; Elsevier Ltd.: Oxford, 2008; Vol.11, 409-499.
    • (2008) Comprehensive Heterocyclic Chemistry III , vol.11 , pp. 409-499
    • Couty, F.1    Evano, G.2
  • 33
    • 70749087932 scopus 로고    scopus 로고
    • note
    • The diastereomers were separable by chromatography, allowing isolation of the major adduct with the yields reported in Table 2. It was possible to isolate also the cis isomer of compounds 11-15.
  • 37
    • 70749152961 scopus 로고    scopus 로고
    • note
    • This high selectivity can be explained with the higher lability of the bond on C8a due to the presence of the carbonyl. This situation allows a rapid equilibration toward the trans isomer even in the presence of small amounts of acid .
  • 38
    • 70749138967 scopus 로고    scopus 로고
    • See Supporting Information for ORTEP of 27
    • See Supporting Information for ORTEP of 27.
  • 39
    • 70749153787 scopus 로고    scopus 로고
    • WO 2004092166 A2 20041028. Knaup, G. DE 10020818 Al 20011031
    • 3-Aminoazepanones substituted in position 7 have been previously described in several patents as structures of pharmaceutic interest. See for example: Burgey, C. S.; Deng, Z. J.; Nguyen, D. N.; Paone, D. L. V.; Shaw, A. W.; Williams, T. M. WO 2004092166 A2 20041028. Knaup, G. DE 10020818 Al 20011031
    • Burgey, C.S.1    Deng, Z.J.2    Nguyen, D.N.3    Paone, D.L.V.4    Shaw, A.W.5    Williams, T.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.