Subtype specific estrogen receptor action protects against changes in MMP-2 activation in mouse retinal pigmented epithelial cells

Experimental Eye Research

Volumn 86, Issue 4, 2008, Pages 653-660

  Elliot, Sharon ^a   Catanuto, Paola ^a   Fernandez, Pedro ^a   Espinosa Heidmann, Diego ^a   Karl, Michael ^a   Korach, Kenneth ^b   Cousins, Scott W ^c  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c DUKE UNIVERSITY EYE CENTER   (United States)

Author keywords

age related macular degeneration; estrogen; estrogen receptor; extracellular matrix; matrix metalloproteinases; tissue inhibitors of metalloproteinases

Indexed keywords

ESTROGEN RECEPTOR; GELATINASE A; LUCIFERASE; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; EPITHELIUM CELL; EXTRACELLULAR MATRIX; FEMALE; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION;

ANIMALS; CELL LINE; ENZYME ACTIVATION; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 2; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXIDATIVE STRESS; PIGMENT EPITHELIUM OF EYE; RETINA; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TRANSFECTION;

EID: 41049093223     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2008.01.010     Document Type: Article

References (47)

1. Ahir A., et al. Expression of metalloproteinases from human retinal pigment epithelial cells and their effects on the hydraulic conductivity of Bruch's membrane. Invest. Ophthalmol. Vis. Sci. 43 (2002) 458-465
2. Alfonso-Jaume M.A., et al. Co-operative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells. Biochem. J. 380 (2004) 735-747
3. 2 exposure. Lab. Invest. 77 (1997) 533-539
4. Berger J.W., et al. Age-Related Macular Degeneration (1999), Mosby, St. Louis
5. Bjornstrom L., and Sjoberg M. Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol. Endocrinol. 19 (2005) 833-842
6. Blush J., et al. Estradiol reverses renal injury in Alb/TGF-beta1 transgenic mice. Kidney Int. 66 (2004) 2148-2154
7. Campochiaro P.A., et al. The extracellular matrix of human retinal pigment epithelial cells in vivo and its synthesis in vitro. Invest. Ophthalmol. Vis. Sci. 27 (1986) 1615-1621
8. Catanuto, P. et al., 2007. Immortalization of mouse retinal pigmented epithelial cell lines: a new tool to further age related macular degeneration research. Annual Meeting of the Association for Research in Vision and Opthalmology.
9. Corcoran M.L., et al. MMP-2: expression, activation and inhibition. Enzyme Protein 49 (1996) 7-19
10. Cousins S.W., et al. Female gender, estrogen loss, and Sub-RPE deposit formation in aged mice. Invest. Ophthalmol. Vis. Sci. 44 (2003) 1221-1229
11. Dollery C.M., and Libby P. Atherosclerosis and proteinase activation. Cardiovascular Research 69 (2006) 625-635
12. Eichler W., et al. Modulation of matrix metalloproteinase and TIMP-1 expression by cytokines in human RPE cells. Invest. Ophthalmol. Vis. Sci. 43 (2002) 2767-2773
13. Elliot S., et al. Retinal pigment epithelium protection from oxidant-mediated loss of MMP-2 activation requires both MMP-14 and TIMP-2. Invest. Ophthalmol. Vis. Sci. 47 (2006) 1697-1702
14. Espinosa-Heidmann D.G., et al. Gender and estrogen supplementation increases severity of experimental choroidal neovascularization. Exp. Eye Res. 80 (2005) 413-423
15. Fine S.L., et al. Age-related macular degeneration. N. Engl. J. Med. 342 (2000) 483-492
16. Fontijn R., et al. Maintenance of vascular endothelial cell-specific properties after immortalization with an amphotrophic replication-deficient retrovirus containing human papilloma virus 16 E6/E7 DNA. Exp. Cell Res. 216 (1995) 199-207
17. Friedman D.S., et al. Prevalence of age-related macular degeneration in the United States. Arch. Ophthalmol. 122 (2004) 564-572
18. Gilliver S.C., et al. The hormonal regulation of cutaneous wound healing. Clin. Dermatol. 25 (2007) 56-62
19. Greco B., et al. Coexpression of ER beta with ER alpha and progestin receptor proteins in the female rat forebrain: effects of estradiol treatment. Endocrinology 142 (2001) 5172-5181
20. Green W.R. Histopathology of age-related macular degeneration. Mol. Vis. 5 (1999) 27
21. Hall J.M., and McDonnell D.P. The estrogen receptor beta-isoform (ERbeta) of the human estrogen receptor modulates ERalpha transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 140 (1999) 5566-5578
22. Hamel C.P., et al. Molecular cloning and expression of RPE65, a novel retinal pigment epithelium-specific microsomal protein that is post-transcriptionally regulated in vitro. J. Biol. Chem. 268 (1993) 15751-15757
23. Harendza S., et al. Linked common polymorphisms in the gelatinase a promoter are associated with diminished transcriptional response to estrogen and genetic fitness. J. Biol. Chem. 278 (2003) 20490-20499
24. Itoh Y., and Seiki M. MT1-MMP: an enzyme with multidimensional regulation. Trends Biochem. Sci. 29 (2004) 285-289
25. Karl M., et al. Autocrine activation of the local insulin-like growth factor I system is up-regulated by estrogen receptor (ER)-independent estrogen actions and accounts for decreased ER expression in type 2 diabetic mesangial cells. Endocrinology 146 (2005) 889-900
26. Karl M., et al. Differential effects of continuous and intermittent 17beta-estradiol replacement and tamoxifen therapy on the prevention of glomerulosclerosis: modulation of the mesangial cell phenotype in vivo. Am. J. Pathol. 169 (2006) 351-361
27. Lei J., et al. Serum-stimulated alpha 1 type IV collagen gene transcription is mediated by TGF-beta and inhibited by estradiol. Am. J. Physiol. 274 (1998) F252-F258
28. Liang X., et al. Oxidant stress impaired DNA-binding of estrogen receptor from human breast cancer. Mol. Cell. Endocrinol. 146 (1998) 151-161
29. Liao E.Y., et al. Membrane-type matrix metalloproteinase-1 (MT1-MMP) is down-regulated in estrogen-deficient rat osteoblast in vivo. J. Endocrinol. Invest. 27 (2004) 1-5
30. Marin-Castano M.E., et al. Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium. Invest. Ophthalmol. Vis. Sci. 44 (2003) 50-59
31. Marin-Castano M.E., et al. Nonlethal oxidant injury to human retinal pigment epithelium cells causes cell membrane blebbing but decreased MMP-2 activity. Invest. Ophthalmol. Vis. Sci. 46 (2005) 3331-3340
32. Marin-Castano M.E., et al. Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo. Invest. Ophthalmol. Vis. Sci. 47 (2006) 4098-4112
33. Mattana J., et al. Oxidation of the mesangial matrix metalloproteinase-2 impairs gelatinolytic activity. Inflammation 22 (1998) 269-276
34. Matthews J., et al. ER{beta} modulates ER{alpha}-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen responsive promoters. Mol. Endocrinol. 20 (2006) 534-543
35. Matthews J., and Gustafsson J.A. Estrogen signaling: a subtle balance between ER alpha and ER beta. Mol. Interv. 3 (2003) 281-292
36. Mor G., et al. The role of the Fas/Fas ligand system in estrogen-induced thymic alteration. Am. J. Reprod. Immunol. 46 (2001) 298-307
37. Nagase H., et al. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc. Res. 69 (2006) 562-573
38. Nicolas M., et al. Cloning and characterization of the 5′-flanking region of the human transcription factor Sp1 gene. J. Biol. Chem. 276 (2001) 22126-22132
39. Padgett L.C., et al. Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 in the retinal pigment epithelium and interphotoreceptor matrix: vectorial secretion and regulation. Exp. Eye Res. 64 (1997) 927-938
40. Peten E.P., et al. Age-related changes in alpha 1- and alpha 2-chain type IV collagen mRNAs in adult mouse glomeruli: competitive PCR. Am. J. Physiol. 263 (1992) F951-F957
41. Potier M., et al. Estrogen-related abnormalities in glomerulosclerosis-prone mice: reduced mesangial cell estrogen receptor expression and prosclerotic response to estrogens. Am. J. Pathol. 160 (2002) 1877-1885
42. Potier M., et al. Expression and regulation of estrogen receptors in mesangial cells: influence on matrix metalloproteinase-9. J. Am. Soc. Nephrol. 12 (2001) 241-251
43. Price S.J., et al. Identification of novel, functional genetic variants in the human matrix metalloproteinase-2 gene: role of Sp1 in allele-specific transcriptional regulation. J. Biol. Chem. 276 (2001) 7549-7558
44. Quong J., et al. Age-dependent changes in breast cancer hormone receptors and oxidant stress markers. Breast Cancer Res. Treat. 76 (2002) 221-236
45. Saville B., et al. Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements. J. Biol. Chem. 275 (2000) 5379-5387
46. Webster K.A., et al. Oxidation of zinc finger transcription factors: physiological consequences. Antioxid. Redox. Signal. 3 (2001) 535-548
47. Wingrove C.S., et al. 17beta-oestradiol enhances release of matrix metalloproteinase-2 from human vascular smooth muscle cells. Biochim. Biophys. Acta 1406 (1998) 169-174