Solid phase synthesis of fatty acid modified glucagon-like peptide-1 (7-36) amide under thermal and controlled microwave irradiation

Chinese Chemical Letters

Volumn 21, Issue 1, 2010, Pages 27-30

  Ni, Shuai Jian ^a   Zhang, Hui Bin ^a   Huang, Wen Long ^a   Zhou, Jin Pei ^a   Qian, Hai ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Fatty acid modification; GLP 1; Glucagon like peptide 1; Microwave; Solid phase

Indexed keywords

EID: 70749092265     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cclet.2009.08.007     Document Type: Article

References (11)

1. Nauck M.A., Kleine N., Orskov C., et al. Diabetologia 36 (1993) 741
2. Hvidberg A., Nielsen M.T., Hilsted J., et al. Metabolism 43 (1994) 104
3. Deacon C.F., Nauck M.A., Toft-Nielsen M., et al. Diabetes 44 (1995) 1126
4. Madsen K., Knudsen L.B., Agersoe H., et al. J. Med. Chem. 50 (2007) 6126
5. Oliver Kappe C. Angew. Chem. Int. Ed. 43 (2004) 6250
6. Matsushita T., Hinou H., Kurogochi M., et al. Org. Lett. 7 (2005) 877
7. Xu J. Prog. Chem. 19 (2007) 700
8. Murray J.K., and Gellman S.H. Org. Lett. 7 (2005) 1517
9. Kaiser E., Colescott R.L., Bossinger C.D., et al. Anal. Biochem. 34 (1970) 595
10. 2O; buffer B: acetonitrile, linear gradient 30-45% B in 25 min, flow rate: 1.0 mL/min, UV detection: 214 nm, column temperature: 35 °C.
11. 2O; buffer B: methanol, linear gradient 20-70% B in 30 min, flow rate: 5.0 mL/min, UV detection: 214 nm.