Clinical benefits of tight glycaemic control: Focus on the paediatric patient

Best Practice and Research: Clinical Anaesthesiology

Volumn 23, Issue 4, 2009, Pages 441-448

  van den Heuvel, Ingeborg ^a   Vlasselaers, Dirk ^b  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

hyperglycaemia; paediatric intensive care; tight glycaemic control

Indexed keywords

ADRENALIN; C REACTIVE PROTEIN; GLUCOSE; INSULIN; VASOACTIVE AGENT;

ARTIFICIAL VENTILATION; CALORIC INTAKE; CHILD HEALTH CARE; CLINICAL TRIAL; COMORBIDITY; CONTINUOUS INFUSION; CRITICAL ILLNESS; CRITICALLY ILL PATIENT; DIABETES MELLITUS; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG DOSE TITRATION; DRUG SAFETY; GLUCOSE BLOOD LEVEL; GLUCOSURIA; GLYCEMIC CONTROL; HEMODYNAMICS; HOSPITAL INFECTION; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INFECTION PREVENTION; INTENSIVE CARE; MEDICAL TECHNOLOGY; MORBIDITY; MORTALITY; NONHUMAN; PATIENT MONITORING; PRIORITY JOURNAL; REFERENCE VALUE; REVIEW; SECONDARY INFECTION; SURGICAL PATIENT; SURVIVAL RATE; TREATMENT OUTCOME;

BLOOD GLUCOSE; CHILD; CRITICAL ILLNESS; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; INTENSIVE CARE; INTENSIVE CARE UNITS, PEDIATRIC; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 70649100421     PISSN: 15216896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpa.2009.08.002     Document Type: Review

References (51)

1. Hirshberg E., Lacroix J., Sward K., et al. Blood glucose control in critically ill adults and children: a survey on stated practice. Chest 133 (2008) 1328-1335
2. Nayak P., Lang H., Parslow R., et al. UK Paediatric Intensive Care Society Study Group (PICS SG). Hyperglycemia and insulin therapy in the critically ill child. Pediatric Critical Care Medicine 10 (2009) 303-305
3. Faustino E.V., and Apkon M. Persistent hyperglycemia in critically ill children. The Journal of Pediatrics 146 (2005) 30-34
4. Wintergerst K.A., Deiss D., Buckingham B., et al. Glucose control in pediatric intensive care unit patients using an insulin-glucose algorithm. Diabetes Technology & Therapeutics 9 (2007) 211-222
5. Srinivasan V., Spinella P.C., Drott H.R., et al. Association of timing, duration, and intensity of hyperglycemia with intensive care unit mortality in critically ill children. Pediatric Critical Care Medicine 5 (2004) 329-336
6. Klein G.W., Hojsak J.M., Schmeidler J., et al. Hyperglycemia and outcome in the pediatric intensive care unit. The Journal of Pediatrics 153 (2008) 379-384
7. Polito A., Thiagarajan R.R., Laussen P.C., et al. Association between intraoperative and early postoperative glucose levels and adverse outcomes after complex congenital heart surgery. Circulation 118 (2008) 2235-2242
8. Falcao G., Ulate K., Kouzekanani K., et al. Impact of postoperative hyperglycemia following surgical repair of congenital cardiac defects. Pediatric Cardiology 29 (2008) 628-636
9. Yates A.R., Dyke II P.C., Taeed R., et al. Hyperglycemia is a marker for poor outcome in the postoperative pediatric cardiac patient. Pediatric Critical Care Medicine 7 (2006) 351-355
10. Ghafoori A.F., Twite M.D., and Friesen R.H. Postoperative hyperglycemia is associated with mediastinitis following pediatric cardiac surgery. Paediatric Anaesthesia 18 (2008) 1202-1207
11. Rossano J.W., Taylor M.D., Smith E.O., et al. Glycemic profile in infants who have undergone the arterial switch operation: hyperglycemia is not associated with adverse events. The Journal of Thoracic and Cardiovascular Surgery 135 (2008) 739-745
12. de Ferranti S., Gauvreau K., Hickey P.R., et al. Intraoperative hyperglycemia during infant cardiac surgery is not associated with adverse neurodevelopmental outcomes at 1, 4, and 8 years. Anesthesiology 100 (2004) 1345-1352
13. Heimann K., Peschgens T., Kwiecien R., et al. Are recurrent hyperglycemic episodes and median blood glucose level a prognostic factor for increased morbidity and mortality in premature infants
14. Hall N.J., Peters M., Eaton S., et al. Hyperglycemia is associated with increased morbidity and mortality rates in neonates with necrotizing enterocolitis. Journal of Pediatric Surgery 39 (2004) 898 901; discussion 898-901
15. Branco R.G., Garcia P.C., Piva J.P., et al. Glucose level and risk of mortality in pediatric septic shock. Pediatric Critical Care Medicine 6 (2005) 470-472
16. Day K.M., Haub N., Betts H., and Inward D.P. Hyperglycemia is associated with morbidity in critically ill children with meningococcal sepsis. Pediatric Critical Care Medicine 9 (2008) 636-640
17. Gore D.C., Chinkes D., Heggers J., et al. Association of hyperglycemia with increased mortality after severe burn injury. The Journal of Trauma 51 (2001) 540-544
18. Chiaretti A., De Benedictis R., Langer A., et al. Prognostic implications of hyperglycaemia in paediatric head injury. Child's Nervous System 14 (1998) 455-459
19. Cochran A., Scaife E.R., Hansen K.W., and Downey E.C. Hyperglycemia and outcomes from pediatric traumatic brain injury. The Journal of Trauma 55 (2003) 1035-1038
20. Wintergerst K.A., Buckingham B., Gandrud L., et al. Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit. Pediatrics 118 (2006) 173-179
21. Hirshberg E., Larsen G., and Van Duker H. Alterations in glucose homeostasis in the pediatric intensive care unit: hyperglycemia and glucose variability are associated with increased mortality and morbidity. Pediatric Critical Care Medicine 9 (2008) 361-366
22. Pham T.N., Warren A.J., Phan H.H., et al. Impact of tight glycemic control in severely burned children. The Journal of Trauma 59 (2005) 1148-1154
23. Vlasselaers D., Milants I., Desmet L., et al. Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study. Lancet 373 (2009) 547-556
24. Turina M., Fry D.E., and Polk Jr. H.C. Acute hyperglycemia and the innate immune system: clinical, cellular, and molecular aspects. Critical Care Medicine 33 (2005) 1624-1633
25. Weekers F., Giulietti A.P., Michalaki M., et al. Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. Endocrinology 144 (2003) 5329-5338
26. Hansen T.K., Thiel S., Wouters P.J., et al. Intensive insulin therapy exerts antiinflammatory effects in critically ill patients and counteracts the adverse effect of low mannose-binding lectin levels. The Journal of Clinical Endocrinology and Metabolism 88 (2003) 1082-1088
27. Joosten K., Verbruggen S.C., and Verhoeven J.J. Glycaemic control in paediatric critical care. Lancet 373 (2009) 1423-1424
28. Beardsall K., Vanhaesebrouck S., Ogilvy-Stuart A.L., et al. Early insulin therapy in very-low-birth-weight infants. The New England Journal of Medicine 359 (2008) 1873-1884
29. Zylberberg R., and Pepper M. Continuous insulin infusion: promoting growth in low birth weight infants. Neonatal Network 20 (2001) 17-24
30. Zuurbier C.J., Bos A.P., and van Wezel H.B. Glycaemic control in paediatric critical care. Lancet 373 (2009) 1423 author reply 1424
31. Preissig C., and Rigby M. Glycaemic control in paediatric critical care. Lancet 373 (2009) 1423 author reply 1424
32. Van den Berghe G. How does blood glucose control with insulin save lives in intensive care?. The Journal of Clinical Investigation 114 (2004) 1187-1195
33. Ellger B., Debaveye Y., Vanhorebeek I., et al. Survival benefits of intensive insulin therapy in critical illness: impact of maintaining normoglycemia versus glycemia-independent actions of insulin. Diabetes 55 (2006) 1096-1105
34. Vanhorebeek I., Ellger B., De Vos R., et al. Tissue-specific glucose toxicity induces mitochondrial damage in a burn injury model of critical illness. Critical Care Medicine 37 (2009) 1355-1364
35. Preissig C.M., Hansen I., Roerig P.L., and Rigby M.R. A protocolized approach to identify and manage hyperglycemia in a pediatric critical care unit. Critical Care Medicine 9 (2008) 581-588
36. van den Berghe G., Wouters P., Weekers F., et al. Intensive insulin therapy in the critically ill patients. The New England Journal of Medicine 345 (2001) 1359-1367
37. NICE-SUGAR Study Investigators, Finfer S., Chittock D.R., et al. Intensive versus conventional glucose control in critically ill patients. The New England Journal of Medicine 360 (2009) 1283-1297
38. Hoedemaekers C.W., Klein Gunnewiek J.M., Prinsen M.A., et al. Accuracy of bedside glucose measurement from three glucometers in critically ill patients. Critical Care Medicine 36 (2008) 3062-3066
39. Kanji S., Buffie J., Hutton B., et al. Reliability of point-of-care testing for glucose measurement in critically ill adults. Critical Care Medicine 33 (2005) 2778-2785
40. Vlasselaers D., Van Herpe T., Milants I., et al. Blood glucose measurements in arterial blood of ICU patients submitted to tight glycemic control: agreement between bedside tests. Diabetes Science and Technology 2 (2008) 932-938
41. Cornblath M., Schwartz R., Aynsley-Green A., and Lloyd J.K. Hypoglycemia in infancy: the need for a rational definition. A Ciba Foundation Discussion Meeting. Pediatrics 85 (1990) 834-837
42. Pildes R.S. Neonatal hyperglycemia. The Journal of Pediatrics 109 (1986) 905-907
43. Pildes R.S., and Pyati S.P. Hypoglycemia and hyperglycemia in tiny infants. Clinics in Perinatology 13 (1986) 351-375
44. Malone J.I., Hanna S., Saporta S., et al. Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory. Pediatric Diabetes 9 (2008) 531-539
45. Vriesendorp T.M., van Santen S., DeVries J.H., et al. Predisposing factors for hypoglycemia in the intensive care unit. Critical Care Medicine 34 (2006) 96-101
46. Cornblath M., Hawdon J.M., Williams A.F., et al. Controversies regarding definition of neonatal hypoglycemia: suggested operational thresholds. Pediatrics 105 (2000) 1141-1145
47. Lucas A., Morley R., and Cole T.J. Adverse neurodevelopmental outcome of moderate neonatal hypoglycaemia. BMJ 297 (1988) 1304-1308
48. Tam E.W., Widjaja E., Blaser S.I., et al. Occipital lobe injury and cortical visual outcomes after neonatal hypoglycemia. Pediatrics 122 (2008) 507-512
49. Allen H.F., Rake A., Roy M., et al. Prospective detection of hyperglycemia in critically ill children using continuous glucose monitoring. Pediatric Critical Care Medicine 9 (2008) 153-158
50. Vogelzang M., Zijlstra F., and Nijsten M.W. Design and implementation of GRIP: a computerized glucose control system at a surgical intensive care unit. BMC Medical Informatics and Decision making 5 (2005) 38
51. Vlasselaers D., Schaupp L., van den Heuvel I., et al. Monitoring blood glucose with microdialysis of interstitial fluid in critically ill children. Clinical Chemistry 53 (2007) 536-537