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Volumn 877, Issue 32, 2009, Pages 4171-4174
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Rapid determination of tacrine and other drug metabolites in microsomal incubate by newly developed targeting algorithm on UHPLC/TOFMS
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Author keywords
Cytochrome P450; High throughput; Tacrine; Targeting algorithm; UHPLC TOFMS
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Indexed keywords
ACTIVITY ASSAYS;
ANALYSIS TIME;
CHROMATOGRAPHIC PEAKS;
COLLISION INDUCED DISSOCIATION;
COMPUTER ASSISTED;
CYTOCHROME P450;
DRUG DISCOVERY PROCESS;
DRUG METABOLITES;
FLIGHT MASS SPECTROMETRY;
HIGH-THROUGHPUT;
IN-SOURCE CID;
IN-VITRO;
INTENSITY DIFFERENCE;
INTERNAL DIAMETERS;
MASS SPECTRA;
PACKING MATERIALS;
PEAK WIDTHS;
QUALITATIVE AND QUANTITATIVE ANALYSIS;
QUANTITATIVE ANALYSIS;
RAPID DETERMINATION;
REVERSED PHASE CHROMATOGRAPHY;
SIMULTANEOUS DETERMINATIONS;
ULTRA HIGH PERFORMANCE;
AMINES;
ASSAYS;
BIOMOLECULES;
CHROMATOGRAPHIC ANALYSIS;
CHROMATOGRAPHY;
COMPUTER CRIME;
DECONVOLUTION;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
LIQUIDS;
MASS SPECTROMETERS;
MASS SPECTROMETRY;
METABOLISM;
METABOLITES;
ENZYME INHIBITION;
CYTOCHROME P450;
PHENACETIN;
TACRINE;
TOLBUTAMIDE;
ARTICLE;
CHEMICAL ANALYSIS;
CHEMICAL STRUCTURE;
COLLISIONALLY ACTIVATED DISSOCIATION;
ENZYME INHIBITION;
IN VITRO STUDY;
LIQUID CHROMATOGRAPHY;
PRIORITY JOURNAL;
REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
TIME OF FLIGHT MASS SPECTROMETRY;
ULTRA HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
ALGORITHMS;
ANIMALS;
CATTLE;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
CYTOCHROME P-450 ENZYME SYSTEM;
MASS SPECTROMETRY;
MICROSOMES, LIVER;
NOOTROPIC AGENTS;
TACRINE;
TIME FACTORS;
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EID: 70649093013
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2009.11.003 Document Type: Article |
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Times cited : (6)
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References (6)
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