Identification of candidate genes for rituximab response in rheumatoid arthritis patients by microarray expression profiling in blood cells

Pharmacogenomics

Volumn 10, Issue 10, 2009, Pages 1697-1708

  Julià, Antonio ^a   Barceló, Mireia ^a   Erra, Alba ^a   Palacio, Carles ^a   Marsal, Sara ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

Biological agents; Biomarkers; Gene expression microarray; Response to therapy; Rheumatoid arthritis; Rituximab

Indexed keywords

RITUXIMAB; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1;

ADULT; ARTICLE; B LYMPHOCYTE; BLOOD CELL; CD4+ T LYMPHOCYTE; CELL ISOLATION; CELL POPULATION; CLINICAL ARTICLE; DOWN REGULATION; DRUG RESPONSE; FEMALE; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; RNA EXTRACTION; UPREGULATION;

ANTIBODIES, MONOCLONAL; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; B-LYMPHOCYTES; BIOLOGICAL MARKERS; CD4-POSITIVE T-LYMPHOCYTES; CLUSTER ANALYSIS; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMANS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; RNA; TREATMENT OUTCOME;

EID: 70649088946     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.09.99     Document Type: Article

References (48)

1. Firestein GS: Evolving concepts of rheumatoid arthritis. Nature 423, 356-361 (2003).
2. Smolen JS, Aletaha D, Koeller M, Weisman MH, Emery P: New therapies for treatment of rheumatoid arthritis. Lancet 370, 1861-1874 (2007). ■ Review of new therapies recently approved for rheumatoid arthritis (RA) treatment and description of their mode of action.
3. Olsen NJ, Stein CM: New drugs for rheumatoid arthritis. N. Engl. J. Med. 350, 2167-2179 (2004).
4. Edwards JC, Szczepanski L, Szechinski J et al.: Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N. Engl. J. Med. 350, 2572-2581 (2004). ■ Confirms the efficacy of rituximab in patients with RA. (Pubitemid 38758544)
5. Rubbert-Roth A, Finckh A: Treatment options in patients with rheumatoid arthritis failing initial TNF inhibitor therapy: a critical review. Arthritis Res. Ther. 11(Suppl. 1), S1 (2009).
6. Caporali R, Caprioli M, Bobbio-Pallavicini F, Bugatti S, Montecucco C: Long term treatment of rheumatoid arthritis with rituximab. Autoimmun. Rev. 8, 591-594 (2009). ■ Overview of rituximab treatment efficacy and safety in RA after the first 5 years.
7. Arnett FC, Edworthy SM, Bloch DA et al.: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31, 315-324 (1988).
8. Prevoo ML, van't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL: Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 38, 44-48 (1995).
9. Liu C, Batliwalla F, Li W et al.: Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis. Mol. Med. 14, 575-581 (2008).
10. van Gestel AM, Haagsma CJ, van Riel PL: Validation of rheumatoid arthritis improvement criteria that include simplified joint counts. Arthritis Rheum. 41, 1845-1850 (1998).
11. Whitney AR, Diehn M, Popper SJ et al.: Individuality and variation in gene expression patterns in human blood. Proc. Natl Acad. Sci. USA 100, 1896-1901 (2003).
12. Bolstad BM, Irizarry RA, Astrand M, Speed TP: A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19, 185-193 (2003). (Pubitemid 36181903)
13. R Development Core Team: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria (2006).
14. Benjamini Y, Hochberg MC: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. 57, 289-300 (1995).
15. Beissbarth T, Speed TP: GOstat: find statistically overrepresented Gene ontologies within a group of genes. Bioinformatics 20, 1464-1465 (2004). (Pubitemid 38931420)
16. Visser H, le Cessie S, Vos K, Breedveld FC, Hazes JM: How to diagnose rheumatoid arthritis early: a prediction model for persistent (erosive) arthritis. Arthritis Rheum. 46, 357-365 (2002). (Pubitemid 34136572)
17. Klareskog L, Catrina AI, Paget S: Rheumatoid arthritis. Lancet 373, 659-672 (2009). ■ Updated and comprehensive review of knowledge on RA pathology with current limitations and future challenges.
18. Teng YK, Levarht EW, Hashemi M et al.: Immunohistochemical ana lysis as a means to predict responsiveness to rituximab treatment. Arthritis Rheum. 56, 3909-3918 (2007). (Pubitemid 350262317)
19. Roll P, Dorner T, Tony HP: Anti-CD20 therapy in patients with rheumatoid arthritis: predictors of response and B cell subset regeneration after repeated treatment. Arthritis Rheum. 58, 1566-1575 (2008). ■ One of the first attempts to identify a predictor of rituximab response. (Pubitemid 351847509)
20. Cohen SB, Emery P, Greenwald MW et al.: Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a multicenter, randomized, double-blind, placebo-controlled, Phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum. 54, 2793-2806 (2006). (Pubitemid 44497758)
21. Isaacs JD, Olech E, Tak PP et al.: Autoantibody-positive rheumatoid arthritis patients have enhanced clinical response to rituximab when compared with seronegative patients. Presented at: 10th EULAR Congress, Copenhagen, Denmark, 10-13 June 2009. ■ Genomewide association study in North America and Swedish cohorts showing anassociation of the TRAF1 locus in RA susceptibility.
22. Dass S, Rawstron AC, Vital EM, Henshaw K, McGonagle D, Emery P: Highly sensitive B cell ana lysis predicts response to rituximab therapy in rheumatoid arthritis. Arthritis Rheum. 58, 2993-2999 (2008).
23. Gulfe A, Geborek P, Saxne T: Response criteria for rheumatoid arthritis in clinical practice: how useful are they? Ann. Rheum. Dis. 64, 1186-1189 (2005). (Pubitemid 41113354)
24. Felson DT, Anderson JJ, Boers M et al.: American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum. 38, 727-735 (1995).
25. Gulfe A, Aletaha D, Saxne T, Geborek P: Disease activity level, remission and response in established rheumatoid arthritis: performance of various criteria sets in an observational cohort, treated with anti-TNF agents. BMC Musculoskelet. Disord. 10, 41 (2009).
26. Smolen JS, Steiner G: Therapeutic strategies for rheumatoid arthritis. Nat. Rev. Drug Discov. 2, 473-488 (2003).
27. Jacobsen LC, Theilgaard-Monch K, Christensen EI, Borregaard N: Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils. Blood 109, 3084-3087 (2007). (Pubitemid 46482111)
28. Hadkar V, Skidgel RA: Carboxypeptidase D is up-regulated in raw 264.7 macrophages and stimulates nitric oxide synthesis by cells in arginine-free medium. Mol. Pharmacol. 59, 1324-1332 (2001). (Pubitemid 32381612)
29. Morris CR, Poljakovic M, Lavrisha L, Machado L, Kuypers FA, Morris Jr SM: Decreased arginine bioavailability and increased serum arginase activity in asthma. Am. J. Respir. Crit. Care Med. 170, 148-153 (2004). (Pubitemid 38925160)
30. Marletta MA: Nitric oxide synthase structure and mechanism. J. Biol. Chem. 268, 12231-12234 (1993).
31. Schellekens GA, Visser H, de Jong BA et al.: The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 43, 155-163 (2000). (Pubitemid 30368225)
32. Plenge RM, Seielstad M, Padyukov L et al.: TRAF1-C5 as a risk locus for rheumatoid arthritis - a genomewide study. N. Engl. J. Med. 357, 1199-1209 (2007). (Pubitemid 47443179)
33. Raychaudhuri S, Remmers EF, Lee AT et al.: Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat. Genet. 40, 1216-1223 (2008).
34. Arron JR, Walsh MC, Choi Y: TRAF-mediated TNFR-family signaling. Curr. Protoc. Immunol. 11(11), 9D (2002).
35. Fotin-Mleczek M, Henkler F, Hausser A et al.: Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-κB activation. J. Biol. Chem. 279, 677-685 (2004). (Pubitemid 38044872)
36. Xie P, Hostager BS, Munroe ME, Moore CR, Bishop GA: Cooperation between TNF receptor-associated factors 1 and 2 in CD40 signaling. J. Immunol. 176, 5388-5400 (2006).
37. O'Neill LA, Bryant CE, Doyle SL: Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol. Rev. 27, 27 (2009).
38. Raffeiner B, Dejaco C, Duftner C et al.: Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis. Arthritis Res. Ther. 7, R1412-R14120 (2005).
39. + T cells via TLR4 complex. Eur. J. Immunol. 39, 1564-1572 (2009).
40. + T cell effector function in a murine model of inflammatory bowel disease. J. Immunol. 180, 1886-1894 (2008).
41. Zanin-Zhorov A, Tal-Lapidot G, Cahalon L et al.: Cutting edge: T cells respond to lipopolysaccharide innately via TLR4 signaling. J. Immunol. 179, 41-44 (2007). (Pubitemid 46986515)
42. Caron G, Duluc D, Fremaux I et al.: Direct stimulation of human T cells via TLR5 and TLR7/8: flagellin and R-848 up-regulate proliferation and IFN-γ production by memory CD4+ T cells. J. Immunol. 175, 1551-1557 (2005). (Pubitemid 41023056)
43. + T cell survival. J. Immunol. 172, 6065-6073 (2004).
44. Komai-Koma M, Jones L, Ogg GS, Xu D, Liew FY: TLR2 is expressed on activated T cells as a costimulatory receptor. Proc. Natl Acad. Sci. USA 101, 3029-3034 (2004). (Pubitemid 38327729)
45. Nixon JC, Rajaiya JB, Ayers N, Evetts S, Webb CF: The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations. Cell Immunol. 228, 42-53 (2004). (Pubitemid 38760122)
46. Illumina homepage http://illumina.com/
47. Gene expression omnibus database http://www.ncbi.nlm.nih.gov/geo/query/ acc.cgi?acc=GSE15316
48. GOstat http://gostat.wehi.edu.au/