Homocysteine and stroke: Another brick in the wall

Clinical Science

Volumn 118, Issue 3, 2010, Pages 183-185

  Sacco, Simona ^a   Carolei, Antonio ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Atherothrombosis; Homocysteine; Intracerebral haemorrhage; Methylenetetrahydrofolate reductase (MTHFR); Mortality; Stroke

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PLACEBO; VITAMIN B GROUP;

AMINO ACID BLOOD LEVEL; BRAIN HEMORRHAGE; CARDIOVASCULAR RISK; CHINESE; CLINICAL TRIAL; DRUG EFFICACY; DRUG MEGADOSE; ETHNIC DIFFERENCE; HUMAN; MORTALITY; NOTE; PREVALENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; RECURRENT DISEASE; RISK FACTOR; STROKE; VITAMIN SUPPLEMENTATION;

BIOLOGICAL MARKERS; FEMALE; HOMOCYSTEINE; HUMANS; MALE; RECURRENCE; RISK FACTORS; STROKE;

EID: 70549103152     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20090371     Document Type: Note

References (15)

1. Wald, D. S., Law, M. and Morris, J. K. (2002) Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. Br. Med. J. 325, 1202-1206
2. Thambyrajah, J. and Townend, J. N. (2000) Homocysteine and atherothrombosis: mechanisms for injury. Eur. Heart J. 21, 967-974
3. Zhang, W., Sun, K., Chen, J., Liao, Y., Qin, Q., Ma, A., Wang, D., Zhu, Z., Wang, Y. and Hui, R. (2010) High plasma homocysteine levels contribute to the risk of stroke recurrence and all-cause mortality in a large prospective stroke population. Clin. Sci. 118, 187-194
4. Eikelboom, J. W., Hankey, G. J., Anand, S. S., Lofthouse, E., Staples, N. and Baker, R. I. (2000) Association between high homocyst(e)ine and ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke. Stroke 31, 1069-1075
5. Ranganath, L. R., Baines, M. and Roberts, N. B. (2001) Homocysteine and thiol metabolites in vitamin B12 deficiency. Clin. Sci. 100, 111-116
6. Stam, F., Smulders, Y. M., van Guldener, C., Jakobs, C., Stehouwer, C. D. and de Meer, K. (2005) Folic acid treatment increases homocysteine remethylation and methionine transmethylation in healthy subjects. Clin. Sci. 108, 449-456
7. Bazzano, L. A., Reynolds, K., Holder, K. N. and He, J. (2006) Effect of folic acid supplementation on risk of cardiovascular diseases: a meta-analysis of randomized controlled trials. JAMA, J. Am. Med. Assoc. 296, 2720-2726
8. Bønaa, K. H., Njolstad, I., Ueland, P. M., Schirmer, H., Tverdal, A., Steigen, T., Wang, H., Nordrehaug, J. E., Arnesen, E. and Rasmussen, K. (2006) Homocysteine lowering and cardiovascular events after acute myocardial infarction. N. Engl. J. Med. 354, 1578-1588
9. Jamison, R. L., Hartigan, P., Kaufman, J. S., Goldfarb, D. S., Warren, S. R., Guarino, P. D. and Gaziano, J. M. (2007) Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial. JAMA, J. Am. Med. Assoc. 298, 1163-1170
10. Lonn, E., Yusuf, S., Arnold, M. J., Sheridan, P., Pogue, J., Micks, M., McQueen, M. J., Probstfield, J., Fodor, G., Held, C. and Genest, J. (2006) Homocysteine lowering with folic acid and B vitamins in vascular disease. N. Engl. J. Med. 354, 1567-1577
11. Toole, J. F., Malinow, M. R., Chambless, L. E., Spence, J. D., Pettigrew, L. C., Howard, V. J., Sides, E. G., Wang, C. H. and Stampfer, M. (2004) Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the vitamin intervention for stroke prevention (VISP) randomized controlled trial. JAMA, J. Am. Med. Assoc. 291, 565-575
12. Sacco, S. and Carolei, A. (2007) Homocysteine and leukoaraiosis: time for a clinical trial? Neurol. Sci. 28, 235-237
13. Spence, J. D., Bang, H., Chambless, L. E. and Stampfer, M. J. (2005) Vitamin intervention for stroke prevention trial: an efficacy analysis. Stroke 36, 2404-2409
14. Li, Z., Sun, L., Zhang, H., Liao, Y., Wang, D., Zhao, B., Zhu, Z., Zhao, J., Ma, A., Han, Y., Wang, Y., Shi, Y. and Ye, J. (2003) Elevated plasma homocysteine was associated with hemorrhagic and ischemic stroke, but methylenetetrahydrofolate reductase gene C677T polymorphism was a risk factor for thrombotic stroke: a Multicenter Case-Control Study in China. Stroke 34, 2085-2090
15. Xue, H., Wang, H., Song, X., Li, W., Sun, K., Zhang, W., Wang, X., Wang, Y. and Hui, R. (2009) Phosphodiesterase 4D gene polymorphism is associated with ischaemic and haemorrhagic stroke. Clin. Sci. 116, 335-340