Steroidal saponins from the rhizomes of Ruscus hypophyllum

Natural Product Communications

Volumn 3, Issue 10, 2008, Pages 1671-1678

  Mimaki, Yoshihiro ^a   Aoki, Tsukasa ^a   Jitsuno, Maki ^a   Yokosuka, Akihito ^a   Kiliç, Ceyda Sibel ^b   Coşkun, Maksut ^b  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b ANKARA UNIVERSITY   (Turkey)

Author keywords

Cholestane glycosides; Furostanol saponins; HL 60 cells; Liliaceae; Ruscus hypophyllum; Spirostanol saponins

Indexed keywords

16BETA [(BETA DEXTRO GLUCOPYRANOSYL)OXY] 3BETA, 22 DIHYDROXYCHOLEST 5 EN 1BETA YL BETA DEXTRO XYLOPYRANOSIDE; 16BETA [(BETA DEXTRO GLUCOPYRANOSYL)OXY] 3BETA, 22 DIHYDROXYCHOLEST 5 EN 3 1BETA YL ALPHA LEVO RHMANOPYRANOSIDE; 26 [(BETA DEXTRO GLUCOPYRANOSYL)OXYL] 3BETA HYDROXY 22ALPHA METHOXYFUROST 5 EN 1BETA YL O ALPHA LEVO RHAMNOPYRANOSYL (1-2) O [BETA DEXTRO XYLOPYRANOSYL (1-3)] BETA DEXTRO GALACTOPYRANOSIDE; 26 [(BETA DEXTRO GLUCOPYRANOSYL)OXY] 22 ALPHA METHOXYFUROST 5 EN 3BETA YL O ALPHA LEVO RHAMNOPYRANOSYL (1-4) BETA DEXTRO GLUCOPYRANOSIDE; 26 [(BETA DEXTRO GLUCOPYRANOSYL)OXY] 3BETA HYDROXY 22ALPHA LEVO RHAMNOPYRANOSYL (1-2) 4 O (2 HYDROXY 3 METHYLPENTANOYL) ALPHA LEVO ARABINOPYRANOSIDE; 26 [(BETA DEXTRO GLUCOPYRANOSYL)OXY] 3BETA HYDROXY 22ALPHA METHOXYFUROST 5 EN 1BETA YL O ALPHA LEVO RHAMNOPYRANOSYL (1-2) O [BETA DEXTRO XYLOPYRANOSYL (1-3)] 4,6 DI O ACETYL BETA DEXTRO GALACTOPYRANOSIDE; 26 [(BETA DEXTRO GLUCOPYRANOSYL)OXY] 3BETA HYDROXY 22ALPHA METHOXYFUROST 5 EN 1BETA YL O ALPHA LEVO RHAMNOPYRANOSYL (1-2) O [BETA DEXTRO XYLOPYRANOSYL (1-3)] 6 O ACETYL BETA DEXTRO GALACTOPYRANOSIDE; 26 [(BETA DEXTRO GLUCOPYRANOSYL)OXY] 3BETA HYDROXY 22ALPHA METHOXYFUROST 5 EN 1BETA YL O ALPHA LEVO RHMANOPYRANOSYL (1-2) BETA DEXTRO GALACTOPYRANOSIDE; 26 [(BETA DEXTRO GLUCOPYRANOSYL)OXY] 3BETA HYDROXY 22ALPHA METHOXYFUROSTA 5,25 (27) DIEN 1BETA YL O ALPHA LEVO RHAMNOPYRANOSYL (1-2) O [BETA DEXTRO XYLOPYRANOSYL (1-3) ALPHA LEVO ARABINOPYRANOSIDE; 3BETA HYDROXYSPIROST 5 EN 1BETA YL O ALPHA LEVO RHAMNOPYRANOSYL (1-2) 6 O ACETYL BETA DEXTRO GALACTOPYRANOSIDE; 3BETA HYDROXYSPIROST 5 EN 1BETA YL O ALPHA LEVO RHAMNOPYRANOSYL (1-2) BETA DEXTRO GALACTOPYRANOSIDE; 3BETA HYDROXYSPIROST 5 EN 1BETA YL O ALPHA LEVO RHAMNOPYRANOSYL (1-2) O [BETA DEXTRO XYLOPYRANOSYL (1-3)] 6 O ACETYL BETA DEXTRO GALACTOPYRANOSIDE; 3BETA HYDROXYSPIROST 5 EN 1BETA YL O ALPHA LEVO RHMANOPYRANOSYL (1-2) O [BETA DEXTRO XYLOPYRANOSYL (1-3)] BETA DEXTRO GALACTOPYRANOSIDE; 3BETA HYDROXYSPIROSTA 5,25 (27) DIEN 1BETA YL O ALPHA LEVO RHAMNOPYRANOSYL (1-2) ALPHA LEVO ARABINOPYRANOSIDE; CHOLESTANE DERIVATIVE; GLYCOSIDE; SAPONIN DERIVATIVE; STEROID; UNCLASSIFIED DRUG;

ARTICLE; CYTOTOXICITY; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; HUMAN; HUMAN CELL; LEUKEMIA CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYTOCHEMISTRY; PROMYELOCYTIC LEUKEMIA; RHIZOME; RUSCUS; RUSCUS HYPOPHYLLUM;

HYPOPHYLLUM; LILIACEAE; RUSCUS;

EID: 70549101463     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x0800301018     Document Type: Article

References (13)

1. Horikawa T, Mimaki Y, Kameyama A, Sashida Y, Nikaido T, Ohmoto T. (1994) Aculeoside A, a novel steroidal saponin containing a deoxyaldoketose from Ruscus aculeatus. Chemistry Letters, 2303-2306.
2. Mimaki Y, Kuroda M, Kameyama A, Yokosuka A, Sashida Y. (1998) New steroidal constituents of the underground parts of Ruscus aculeatus and their cytostatic activity on HL-60 cells. Chemical & Pharmaceutical Bulletin, 46, 298-303. (Pubitemid 28124214)
3. Mimaki Y, Kuroda M, Kameyama A, Yokosuka A, Sashida Y. (1998) Steroidal saponins from the underground parts of Ruscus aculeatus and their cytostatic activity on HL-60 cells. Phytochemistry, 48, 485-493. (Pubitemid 28285106)
4. Mimaki Y, Kuroda M, Yokosuka A, Sashida Y. (1998) Two new bisdesmosidic steroidal saponins from the underground parts of Ruscus aculeatus. Chemical & Pharmaceutical Bulletin, 46, 879-881. (Pubitemid 28257497)
5. Mimaki Y, Kuroda M, Kameyama A, Yokosuka A, Sashida, Y. (1998) Aculeoside B, a new bisdesmosidic spirostanol saponin from the underground parts of Ruscus aculeatus. Journal of Natural Products, 61, 1279-1282. (Pubitemid 28513359)
6. Mimaki Y, Kuroda M, Yokosuka A, Sashida Y. (1999) A spirostanol saponin from the underground parts of Ruscus aculeatus. Phytochemistry, 51, 689-692.
7. Mimaki Y, Aoki T, Jitsuno M, Kiliç CS, Coşkun M. (2008) Steroidal glycosides from the rhizomes of Ruscus hypophyllum. Phytochemistry, 69, 729-737.
8. Murayama M. (1992) Preparation of steroidal compounds as anticancer agents. Japan Kokai Tokkyo Koho, JP 04230696.
9. Silva BP, Bernardo RR, Parente JP. (1998) New furostanol glycosides from Costus spicatus. Fitoterapia, 69, 528-532.
10. Mimaki Y, Kawashima K, Kanmoto T, Sashida Y. (1993) Steroidal glycosides from Allium albopilosum and A. ostrowskianum. Phytochemistry, 34, 799-805.
11. Agrawal PK, Jain DC, Gupta RK, Thakur RS. (1985) Carbon-13 NMR spectroscopy of steroidal sapogenins and steroidal saponins. Phytochemistry, 24, 2479-2496.
12. Kawashima K, Mimaki Y, Sashida Y. (1991) Schubertosides A-D, new (22S)-hydroxycholestane glycosides from Allium schubertii. Chemical & Pharmaceutical Bulletin, 39, 2761-2763.
13. Sargent JM, Taylor CG. (1989) Appraisal of the MTT assay as a rapid test of chemosensitivity in acute myeloid leukaemia. British Journal of Cancer, 60, 206-210.