Liquid chromatography mass spectrometry for the determination of salvianolic acid B, a natural compound from the herb Danshen in rat plasma and application to pharmacokinetic study

Biomedical Chromatography

Volumn 23, Issue 10, 2009, Pages 1073-1078

  Han, De En ^a   Gao, Zi Dong ^b   Zhao, Di ^a   Wang, Lei ^a   Li, Na ^c   Li, Ting Ting ^a   Wu, Lei ^a   Chen, Xi Jing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b HENAN UNIVERSITY   (China)

^c HEILONGJIANG UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Liquid chromatography electrospray ionization mass spectrometry (LC ESI MS); Pharmacokinetic; Salvianolic acid B (Sal B)

Indexed keywords

BODY FLUIDS; ELECTRODEPOSITION; ELECTROSPRAY IONIZATION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; RATS;

ANALYTES; DANSHEN; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; LIQUID CHROMATOGRAPHY-ELECTROSPRAY IONIZATION MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY-ELECTROSPRAY IONIZATION-MASS SPECTROMETRIES; NATURAL COMPOUNDS; PHARMACOKINETIC STUDIES; RAT PLASMA; SALVIANOLIC ACID; SALVIANOLIC ACID B;

PHARMACOKINETICS;

RESVERATROL; SALVIANOLIC ACID B;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DOSE COMPARISON; DRUG HALF LIFE; DRUG STABILITY; DRUG STRUCTURE; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETRY; NEGATIVE ION ELECTROSPRAY; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; RAT; SALVIA MILTIORRHIZA; SENSITIVITY AND SPECIFICITY;

RATTUS;

EID: 70549098823     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1225     Document Type: Article

References (17)

1. Chen YF, Jaw I, Shiao MS and Tsai TH. Determination and pharmacokinetic analysis of Sal B in rat blood and bile by microdialysis and liquid chromatography. Journal of Chromatography A 2005; 1088: 140-145. (Pubitemid 41058812)
2. Chen YL, Hu CS and Lin FY. Sal B attenuates cyclooxygenase-2 expression in vitro in LPS-treated rat aortic smooth muscle cells and in vivo in the apolipoprotein-E deficient mouse aorta. Journal of Cellular Biochemistry 2006; 98: 618-631.
3. Du GH, Qiu Y and Zhang JT. Sal B protects the memory functions against transient cerebral ischemia in mice. Journal of Asian Natural Products Research 2000; 2: 145-152.
4. Li M, Zhao C and Wong RN. Inhibition of shear-induced platelet aggregation in rat by tetramethylpyrazine and Sal B. Clinical Hemorheology and Microcirculation 2004; 31: 97-103. (Pubitemid 39273876)
5. Lin YL, Wu CH and Luo MH. In vitro protective effects of Sal B on primary hepatocytes and hepatic stellate cells. Journal of Ethnopharmacology 2006; 105: 215-222.
6. Liu P, Liu CH and Wang HN. Effect of Sal B on collagen production and mitogen-activated protein kinase activity in rat hepatic stellate cells. Acta Pharmacologica Sinica 2002a; 23: 733-738. (Pubitemid 34887026)
7. Liu P, Hu YY and Liu C. Clinical observation of Sal B in treatment of liver fibrosis in chronic hepatitis B. World Journal of Gastroenterology 2002b; 8: 679-685. (Pubitemid 34918663)
8. Ma YM and Wang TM. A solid-phase extraction method for high-performance liquid chromatographic determination of Sal B in rabbit plasma: application to pharmacokinetic study. Biomedical Chromatography 2007; 21: 217-220. (Pubitemid 46259860)
9. Sugiyama A, Zhu BM, Takahara A, Satoh Y and Hashimoto K. Cardiac effects of Salvia Miltiorrhiza/Dalbergia Odorifera mixture, an intravenously applicable Chinese medicine widely used for patients with ischemic heart disease in China. Circulation Journal. 2002; 66: 182-184. (Pubitemid 34464727)
10. Sze FK, Yeung FF, Wong E and Lau J. Does Danshen improve disability after acute ischaemic stroke? Acta Neurologica Scandinavica 2005; 111: 118-125. (Pubitemid 40175335)
11. Tang MK, Ren DC and Zhang JT. Effect of salvianolic acids from Radix Salviae miltiorrhizae on regional cerebral blood flow and platelet aggregation in rats. Phytomedicine 2002; 9: 405-409.
12. Wang XN, Hu YY and Liu CH. Effects of Sal B on expressions of TGF-beta1 and its receptors in liver of rats with dimethylnitrosamine-induced hepatic fibrosis. Zhong Xi Yi Jie He Xue Bao 2005; 3: 286-289.
13. Wu XJ, Wang YP and Wang W. Free radical scavenging and inhibition of lipid peroxidation by magnesium lithospermate B. Acta Pharmacologica Sinica 2000; 21: 855-858. (Pubitemid 30727175)
14. Wu YJ, Hong CY, Lin SJ, Wu P and Shiao MS. Increase of vitamin E content in LDL and reduction of atherosclerosis in cholesterol-fed rabbits by a water-soluble antioxidant-rich fraction of Salvia miltiorrhiza. Arteriosclerosis Thrombosis and Vascular Biology 1998; 18: 481-486. (Pubitemid 28125644)
15. Wu YT, Chen YF, Hsieh YJ, Jaw I, Shiao MS and Tsai TH. Bioavailability of Sal B in conscious and freely moving rats. International Journal of Pharmaceutics 2006; 326: 25-31. (Pubitemid 44647741)
16. Zhang J, Yu H, Sheng Y, Li L, Ye M and Guo D. HPLC determination and pharmacokinetic studies of Sal B in rat plasma after oral administration of Radix Salviae Miltiorrhizae extract. Biomedical Chromatography 2005; 19: 15-18. (Pubitemid 40305310)
17. Zhao JF, Liu CH and Hu YY. Effect of Sal B on Smad3 expression in hepatic stellate cells. Hepatobiliary and Pancreatic Diseases International 2004; 3: 102-105. (Pubitemid 38256136)