Increase of vitamin e content in LDL and reduction of atherosclerosis in cholesterol-fed rabbits by a water-soluble antioxidant-rich fraction of Salvia miltiorrhiza

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 18, Issue 3, 1998, Pages 481-486

  Wu, Yih Jer ^a   Hong, Chuang Ye ^a,b   Lin, Shing Jong ^a,b   Wu, Paulin ^b   Shiao, Ming Shi ^b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Oxidized LDL; Salvia miltiorrhiza; Salvianolic acid B; Vitamin E atherosclerosis

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; CHOLESTEROL; FREE RADICAL; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN; PROBUCOL; SALVIANOLIC ACID B; SCAVENGER; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; LIPID OXIDATION; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SALVIA MILTIORRHIZA; VASCULAR ENDOTHELIUM;

EID: 0031919197     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.18.3.481     Document Type: Article

References (15)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for 1990s. Nature. 1993;362:801-809.
2. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol: modification of low density lipoproteins that increase its atherogenicity. N Engl J Med. 1989;1989:320:915-924.
3. Cushing SD, Berliner JA, Valente AJ, Territo MC, Navab M, Parhami F, Gerricy RG, Schwartz CJ, Fogelman AM. Minimally modified low density lipoprotein induces monocyte-chemotactic protein-1 in human endothelial cells and SMC. Proc Natl Acad Sci U S A. 1990;87:5134-5138.
4. Lusis AJ, Navab M. Lipoprotein oxidation and gene expression in the artery wall: new opportunities for pharmacological intervention in atherosclerosis. Biochem Pharmacol. 1993;46:2119-2126.
5. Hessler JR, Robertson AL Jr, Chisolm GM. LDL-induced cytotoxicity and its inhibition by HDL in human vascular smooth muscle and endothelial cells in culture. Atherosclerosis. 1979;32:213-229.
6. Parthasarathy S, Printz DJ, Boyd D, Joy L, Steinberg D. Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor. Arteriosclerosis. 1986;6:505-510.
7. Palinski W, Rosenfeld ME, Ylä-Herttuala S, Gurther GC, Socher SA, Butler SW, Parthasarathy S, Carew TE, Steinberg D, Witztum JL. Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci U S A. 1989;86:1372-1376.
8. Ylä-Herttuala S, Palinski W, Buder SW, Picard S, Steinberg D, Witztum JL. Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL. Arterioscler Thromb. 1994;14:32-40.
9. Babiy AV, Gebiciki JM, Sullivan DR. Vitamin E content and low density lipoprotein oxidizability induced by free radicals. Atherosclerosis. 1990;81:175-182.
10. Jialal I, Vega GL, Grundy SM. Physiologic levels of ascorbate inhibit the oxidative modification of low density lipoprotein. Atherosclerosis. 1990;82:185-191.
11. Stampfer MJ, Hennekens CH, Manson JE, Golditz GA, Rosner B, Willett WC. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med. 1993;328:1444-1449.
12. Rimm, EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA, Willett WC. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med. 1993;328:1450-1456.
13. Enstram JE, Kanim LE, Klein MA. Vitamin C intake and mortality among a sample of the United States population. Epidemiology. 1992;3:194-202.
14. Stephens NG, Parsons A, Schofield PM, Kelly F, Cheeseman K, Mitchinson MJ, Brown MJ. Randomized controlled trial of vitamin E in patients with coronary disease: Cambridge heart antioxidant study (CHAOS). Lancet. 1996;347:781-786.
15. Sasahara M, Raines EW, Chait A, Carew TE, Steinberg D, Wahl PW, Ross R. Inhibition of hypercholesterolemia-induced atherosclerosis in the nonhuman primate by probucol. J Clin Invest. 1994;1994:94:155-164.