Fatty liver disease, insulin resistance and adiponectin in an obese pediatric population;Esteatosis hepática, resistencia a la insulina y adiponectina en una población con obesidad

Anales de Pediatria

Volumn 71, Issue 6, 2009, Pages 495-501

  Lopez Capape M ^a   Lopez Bermejo A ^b   Alonso Blanco, M ^c   Lara Orejas, E ^c   Corbaton Blasco J ^c   Barrio Castellanos, R ^c  

^a Hospital la Moraleja   (Spain)

^b HOSPITAL JOSEP TRUETA   (Spain)

^c HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

Adiponectin; Fatty liver disease; Insulin resistance; Metabolic syndrome; Obesity

Indexed keywords

ADIPONECTIN; ALANINE AMINOTRANSFERASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; URIC ACID;

ACANTHOSIS NIGRICANS; ADOLESCENT; ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; BLOOD PRESSURE; BODY MASS; CHILD; CONTROLLED STUDY; ECHOGRAPHY; FATTY LIVER; FEMALE; GLUCOSE METABOLISM; HOMEOSTASIS; HUMAN; HYPERTENSION; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRESCHOOL CHILD; RACE; SCHOOL CHILD;

ADIPONECTIN; ADOLESCENT; CHILD; CHILD, PRESCHOOL; FATTY LIVER; FEMALE; HUMANS; INSULIN RESISTANCE; MALE; OBESITY; PROSPECTIVE STUDIES;

EID: 70450280749     PISSN: 16954033     EISSN: 16959531     Source Type: Journal    
DOI: 10.1016/j.anpedi.2009.07.037     Document Type: Article

References (49)

1. S. Smyth, and A. Heron Diabetes and obesity: the twin epidemics Nat Med 12 2006 75 80
2. D. Preiss, and N. Saltar Non-alcoholic fatty liver disease: an overview of prevalence, diagnosis, pathogenesis and treatment considerations Clin Sci (Lond) 115 2008 141 150
3. S.K. Das, S. Mukherjee, and D.M. Vasudevan Non-alcoholic fatty liver disease: an under-recognized cause with emerging importance Curr Sci 90 2006 659 665
4. M.J. Contos, J. Choudhury, A.S. Mills, and A.J. Sanyal The histologic spectrum of nonalcoholic fatty liver disease Clin Liver Dis 8 2004 481 500
5. A. Franzese, P. Vajro, A. Argenziano, A. Puzziello, M.P. Iannucci, M.C. Saviano, et al. Liver involvement in obese children. Ultrasonography and liver enzyme levels at diagnosis and during follow-up in an Italian population Dig Dis Sci 42 1997 1428 1432
6. J.B. Schwimmer, R. Deutsch, J.B. Rauch, C. Behling, R. Newbury, and J.E. Lavine Obesity, insulin resistance, and other clinopathological correlates of pediatric non alcoholic fatty liver disease J Pediatr 143 2003 500 505
7. D.F. Chan Hepatic steatosis in obese Chinese children Int J Obes Relat Metab Disord 28 2004 1257 1263
8. J.B. Schwimmer, R. Deutsch, T. Kaeh, J.E. Lavine, C. Stanley, and C. Behling Prevalence of fatty liver in children and adolescents Pediatrics 118 2006 1388 1393
9. K. Tominaga, J.H. Kurata, Y.K. Chen, E. Fujumoto, S. Miyagawa, A. Ichiro, et al. Prevalence of fatty liver in Japanese children and relationship to obesity Dig Dis Sci 40 1995 2002 2009
10. N.C. Chávez-Tapia, F. Sánchez-ávila, F. Vásquez-Fernández, A. Torres-Machorro, F.I. Tellez-ávila, and M. Uribe Non-alcoholic fatty-liver disease in pediatric populations J Pediatr Endocrinol Metab 20 2007 1059 1073
11. K.M. Utzschneider, and S.E. Kahn Review: The role of insulin resistance in non alcoholic fatty liver disease J Clin Endocrinol Metab 91 2006 4753 4761
12. N. Agarwal, and B.C. Sharma Insulin resistance and clinical aspects of non-alcoholic steatohepatitis (NASH) Hepatol Res 33 2005 92 96
13. G.Q. Shaibi, M.L. Cruz, M.J. Weigensberg, C.M. Toledo-Corral, C.J. Lane, L.A. Nelly, et al. Adiponectin independently predicts metabolic syndrome in overweight latino youth J Clin Endocrinol Metab 92 2007 1809 1812
14. M. Hernández, J. Castellet, J.L. Narvaiza, J.M. Rincón, I. Ruiz, E. Sánchez, et al. Curvas y tablas de crecimiento. Instituto de Investigación sobre Crecimiento y Desarrollo. Fundación Faustino Orbegozo 1988 Garsi Madrid
15. The fourth report on the diagnosis, evaluation and treatment of high blood pressure in children and adolescents. National High Blood Pressure Education Program Working group on High Blood Pressure in children and adolescents. Pediatrics. 2004;114:555-76.
16. M. López-Capapé, M. Alonso, E. Colino, C. Mustieles, J. Corbatón, and R. Barrio Frequency of the metabolic syndrome in obese Spanish pediatric population Eur J Endocrinol 155 2006 313 319
17. American Diabetes Association Diagnosis and classification of diabetes mellitus Diabetes Care 27 2004 5 10
18. S. Cook, M. Weitzman, P. Auinger, M. Nguyen, and W.H. Dietz Prevalence of a metabolic syndrome phenotype in adolescents. Findings from the Third National Health and Nutrition Examination Survey. 1988-1994 Arch Pediatr Adolesc Med 157 2003 821 827
19. M.V. Louthan, S. Barve, C.J. McClain, and S. Joshi-Barve Decrease serum adiponectin: an early event in pediatric non-alcoholic fatty liver disease J Pediatr 147 2005 835 838
20. M. Rashid, and E.A. Roberts Non-alcoholic steato-hepatitis in children J Pediatr Gastroenterol Nutr 30 2000 48 53
21. L.S. Conwell, S.G. Trost, W.J. Brown, and J.A. Batch Indexes of insulin resistance and secretion in obese children and adolescents Diabetes Care 27 2004 314 319
22. S.M. Alavian, A.H. Mohammad-Alizadeh, F. Esna-Ashari, G. Ardalan, and B. Hajarizadeh Non-alcoholic fatty liver disease prevalence among school-age children and adolescents in Iran and its association with biochemical and anthropometric measures Liver Int 29 2009 159 163
23. J.R. Moran, F.K. Ghishan, S.A. Halter, and H.L. Greene Steatohepatitis in obese children. A cause of chronic liver dysfunction Am J Gastroenterol 78 1983 374 377
24. A.E. Feldstein, and M. El-Youssef Non alcoholic fatty liver disease in children: a follow-up study for up to 16 years Gastroenterology 124 2003 A701
25. A.D. Baldridge, A.R. Pérez-Atayde, F. Graeme-Cook, L. Higgins, and J.E. Lavine Idiopathic steatohepatitis in childhood. A multicenter retrospective study J Pediatr 127 1995 700 704
26. V. Nobili, M. Marcellini, R. Devito, P. Ciampalini, F. Piemonte, D. Comparcola, et al. NAFLD in children: a prospective clinical-pathological study and effect of lifestyle advice Hepatology 44 2006 458 465
27. C.C. Zou, L. Liang, F. Hong, J.F. Fu, and Z.Y. Zhao Serum adiponectin, resistin levels and non-alcoholic fatty liver disease in obese children Endocr J 52 2005 519 524
28. D.F. Chan, A.M. Li, W.C. Chu, M.H. Chan, E.M. Wong, E.K. Liu, et al. Hepatic steatosis in obese Chinese children Int J Obes Relat Metab Disord 28 2004 1257 1263
29. A. Sartorio, A. Del Col, F. Agosti, G. Mazzilli, S. Bellentani, C. Tiribelli, et al. Predictors of non-alcoholic fatty liver disease in obese children Eur J Clin Nutr 61 2007 877 883
30. D. Papandreou, I. Rousso, I. Economou, A. Makedou, T. Moudiou, P. Malindretos, et al. Is there any association between high-density lipoprotein, insulin resistance and non-alcoholic fatty liver disease in obese children? Int J Food Sci Nutr 60 2009 312 318
31. S. Saadeh, Z.M. Younossi, E.M. Remer, T. Gramlich, J.P. Ong, M. Hurley, et al. The utility of radiological imaging in non-alcoholic fatty liver disease Gastroenterology 123 2002 745 750
32. A.E. Joseph, S.H. Saverymuttu, S. Al-sam, M.G. Cook, and J.D. Maxwell Comparison of liver histology with ultrasonography in assessing difuse parenchymal liver disease Clin Radiol 43 1991 26 31
33. R. Martos Estepa, F.J. Ruz Rodríguez, M. Valle Jiménez, F. Gascón Luna, F. Bermudo Guitarte, and R. Cañete Estrada Valores elevados de alanina aminotransferasa y colinesterasa en niños obesos prepúberes: correlación con la concentración de insulina basal e índices antropométricos An Pediatr (Barc) 53 2000 330 334
34. M.H. Fishbein, M. Miner, C. Mogren, and J. Chalekson The spectrum of fatty liver in obese children and the relationship of serum aminotransferases to severity of steatosis J Pediatr Gastroenterol Nutr 36 2003 54 61
35. R.S. Strauss, S.E. Barlow, and W.H. Dietz Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents J Pediatr 136 2000 727 733
36. F. Angelico, M. Del Ben, R. Conti, S. Francioso, K. Feole, S. Fiorello, et al. Insulin resistance, the metabolic syndrome and non alcoholic fatty liver disease J Clin Endocrinol Metab 90 2005 1578 1582
37. G. Marchesini, M. Brizi, and A.M. Morselli-Labate Association of non alcoholic fatty liver disease with insulin resistance Am J Med 107 1999 450 455
38. T.S. Burgert, S.E. Taksali, J. Dziura, T.R. Goodman, C.W. Yeckel, X. Papademetris, et al. Alanine aminotransferase levels and fatty liver in childhood obesity: associations with insulin resistance, adiponectin and visceral fat J Clin Endocrinol Metab 91 2006 4287 4294
39. C. Mandato, S. Lucariello, M.R. Licenziati, A. Franzese, M.I. Spagnuolo, R. Ficarella, et al. Metabolic, hormonal, oxidative and inflamatory factors in pediatric obesity-related liver disease J Pediatr 147 2005 62 66
40. B. Bonet Serra, A. Barrio Merino, A. Quintanar Rioja, M. Alavés Buforn, and M. Nevado Santos Esteatosis y cirrosis hepática asociada a resistencia insulínica. Posibles mecanismos fisiopatológicos An Esp Pediatr 56 2002 353 356
41. L. Caballería Rovira, P. Torán Montserrat, M.A. Auladell Llorens, and G. Pera Blanco Esteatosis hepática no alcohólica. Puesta al día Pediatr (Barc) 40 2008 419 424
42. A. Wieckowska, and A.E. Feldstein Non alcoholic fatty liver disease in the pediatric population: a review Curr Opin Pediatr 17 2005 636 641
43. M. Gil-Campos, R.R. Cañete, and A. Gil Adiponectin, the missing link in insulin resistance and obesity Clin Nutr 23 2004 963 974
44. J.C. Winer, T.L. Zern, S.E. Taksali, J. Dziura, A.M. Cali, M. Wollschlager, et al. Adiponectin in childhood and adolescent obesity and its association with inflammatory markers and components of the metabolic syndrome J Clin Endocrinol Metab 91 2006 4415 4423
45. L.A. Adams, P. Angulo, and K.D. Lindor Non alcoholic fatty liver disease Can Med Assoc J 172 2005 899 905
46. M. Santaniemi, Y.A. Kesaniemi, and O. Ukkola Low plasma adiponectin is an indicator of the metabolic syndrome Eur J Endocrinol 155 2006 745 750 (Pubitemid 44857499)
47. A.E. Feldstein, N.W. Werneburg, and A. Canbay Free fatty acids promote hepatic lipotoxicity by stimulating TNF-α expression via a lysosomal pathway Hepatology 40 2004 185 194
48. J.H. Hui, A. Hodge, G.C. Farrell, J.G. Kench, A. Kriketos, and J. George Beyond insulin resistance in NASH: TNF-alpha or adiponectin? Hepatology 40 2004 46 54
49. T. Masaki, S. Chiba, H. Tatsukawa, T. Yasuda, H. Noguchi, N. Seike, et al. Adiponectin protects LPS-induced liver injury through modulation of TNF-α in KK-Ay obese mice Hepatology 40 2004 177 184