The extracellular release of Schistosoma mansoni HMGB1 nuclear protein is mediated by acetylation

Biochemical and Biophysical Research Communications

Volumn 390, Issue 4, 2009, Pages 1245-1249

  Carneiro, Vitor Coutinho ^a   de Moraes Maciel, Renata ^a   de Abreu da Silva, Isabel Caetano ^a   da Costa, Rodrigo Furtado Madeira ^a   Paiva, Claudia Neto ^a   Bozza, Marcelo Torres ^a   Fantappié, Marcelo Rosado ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Acetylation; HMGB1; Inflammation; Schistosoma mansoni; Secretion

Indexed keywords

BINDING PROTEIN; BUTYRIC ACID; CALCINEURIN BINDING PROTEIN 1; HIGH MOBILITY GROUP A PROTEIN; HIGH MOBILITY GROUP B PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; HISTONE ACETYLTRANSFERASE GCN5; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ARTICLE; CELL ASSAY; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; ENZYME SPECIFICITY; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MAMMAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN SECRETION; PROTEIN TRANSPORT; SCHISTOSOMA MANSONI;

ACETYLATION; ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL NUCLEUS; CELLS, CULTURED; HISTONE ACETYLTRANSFERASES; HMGB1 PROTEIN; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI;

MAMMALIA; SCHISTOSOMA MANSONI;

EID: 70450277198     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.10.129     Document Type: Article

References (23)

1. Bustin M. Regulation of DNA-dependent activities by the functional motifs of the high-mobility-group chromosomal proteins. Mol. Cell. Biol. 19 (1999) 5237-5246
2. Scaffidi P., Misteli T., and Bianchi M.E. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418 (2002) 191-195
3. Travers A.A. Priming the nucleosome: a role for HMGB proteins?. EMBO Rep. 4 (2003) 131-136
4. Grasser K.D. Chromatin-associated HMGA and HMGB proteins: versatile co-regulators of DNA-dependent processes. Plant Mol. Biol. 53 (2003) 281-295
5. Stros M., Stokrova J., and Thomas J.O. DNA looping by the HMG-box domains of HMG1 and modulation of DNA binding by the acidic C-terminal domain. Nucleic Acids Res. 22 (1994) 1044-1051
6. van Zoelen M.A., Yang H., Florquin S., Meijers J.C., Akira S., Arnold B., Nawroth P.P., Bierhaus A., Tracey K.J., and van der Poll T. Role of toll-like receptors 2 and 4, and the receptor for advanced glycation end products in high-mobility group box 1-induced inflammation in vivo. Shock 31 (2009) 280-284
7. Yu M., Wang H., Ding A., Golenbock D.T., Latz E., Czura C.J., Fenton M.J., Tracey K.J., and Yang H. HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Shock 26 (2006) 174-179
8. Nagaki S., Yamamoto M., Yumoto Y., Shirakawa H., Yoshida M., and Teraoka H. Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks. Biochem. Biophys. Res. Commun. 246 (1998) 137-141
9. Ugrinova I., Pasheva E.A., Armengaud J., and Pashev I.G. In vivo acetylation of HMG1 protein enhances its binding affinity to distorted DNA structures. Biochemistry 40 (2001) 14655-14660
10. Assenberg R., Webb M., Connolly E., Stott K., Watson M., Hobbs J., and Thomas J.O. A critical role in structure-specific DNA binding for the acetylatable lysine residues in HMGB1. Biochem. J. 411 (2008) 553-561
11. Bonaldi T., Talamo F., Scaffidi P., Ferrera D., Porto A., Bachi A., Rubartelli A., Agresti A., and Bianchi M.E. Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J. 22 (2003) 5551-5560
12. El Gazzar M. HMGB1 modulates inflammatory responses in LPS-activated macrophages. Inflamm. Res. 56 (2007) 162-167
13. Gardella S., Andrei C., Ferrera D., Lotti L.V., Torrisi M.R., Bianchi M.E., and Rubartelli A. The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway. EMBO Rep. 3 (2002) 995-1001
14. Engers H.D., Bergquist R., and Modabber F. Progress on vaccines against parasites. Dev. Biol. Stand. 87 (1996) 73-84
15. de Oliveira F.M., de Abreu da Silva I.C., Rumjanek F.D., Dias-Neto E., Guimaraes P.E., Verjovski-Almeida S., Stros M., and Fantappie M.R. Cloning the genes and DNA binding properties of High Mobility Group B1 (HMGB1) proteins from the human blood flukes Schistosoma mansoni and Schistosoma japonicum. Gene 377 (2006) 33-45
16. Gnanasekar M., Velusamy R., He Y.X., and Ramaswamy K. Cloning and characterization of a high mobility group box 1 (HMGB1) homologue protein from Schistosoma mansoni. Mol. Biochem. Parasitol. 145 (2006) 137-146
17. de Moraes Maciel R., de Silva Dutra D.L., Rumjanek F.D., Juliano L., Juliano M.A., and Fantappie M.R. Schistosoma mansoni histone acetyltransferase GCN5: linking histone acetylation to gene activation. Mol. Biochem. Parasitol. 133 (2004) 131-135
18. Wang H., Yang H., and Tracey K.J. Extracellular role of HMGB1 in inflammation and sepsis. J. Intern. Med. 255 (2004) 320-331
19. Pisetsky D.S., Erlandsson-Harris H., and Andersson U. High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease. Arthritis Res. Ther. 10 (2008) 209
20. Wang H., Ward M.F., and Sama A.E. Novel HMGB1-inhibiting therapeutic agents for experimental sepsis. Shock 32 (2009) 348-357
21. Pasheva E., Sarov M., Bidjekov K., Ugrinova I., Sarg B., Lindner H., and Pashev I.G. In vitro acetylation of HMGB-1 and -2 proteins by CBP: the role of the acidic tail. Biochemistry 43 (2004) 2935-2940
22. Sterner R., Vidali G., and Allfrey V.G. Discrete proteolytic cleavage of high mobility group proteins. Biochem. Biophys. Res. Commun. 89 (1979) 129-133
23. Dyson M., and Walker J.M. Chromatin associated protease from calf thymus. Int. J. Pept. Protein Res. 24 (1984) 201-207