The presence and absence of lymphatic vessels in the adult human intervertebral disc: Relation to disc pathology

Skeletal Radiology

Volumn 38, Issue 12, 2009, Pages 1169-1173

  Kliskey, Karolina ^a   Williams, Kelly ^a   Yu, J ^a   Jackson, David ^b   Urban, Jill ^a   Athanasou, Nick ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Disc; Lymphatics; Pathology; Spine

Indexed keywords

CD31 ANTIGEN; CD34 ANTIGEN; CELL MARKER; LYMPHATIC VESSEL ENDOTHELIAL RECEPTOR 1; MEMBRANE RECEPTOR; PODOPLANIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL PROLIFERATION; CHORDOMA; CONTROLLED STUDY; ENDOTHELIUM CELL; FIBROBLAST; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK HERNIA; LYMPH VESSEL; LYMPH VESSEL ENDOTHELIUM; POSTERIOR LONGITUDINAL LIGAMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SOFT TISSUE; TISSUE DISTRIBUTION;

ADULT; AGED; FEMALE; HUMANS; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DISPLACEMENT; LUMBAR VERTEBRAE; LYMPHATIC VESSELS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; SACRUM; YOUNG ADULT;

EID: 70450265262     PISSN: 03642348     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00256-009-0770-2     Document Type: Article

References (33)

1. DePalma AF, Rothman RH. The intervertebral disc. Oxford:Saunders; 1970. pp 12-6.
2. S Roberts H Evans J Trivedi J Menage 2006 Histology and pathology of the human intervertebral disc J Bone Joint Surg 8A Suppl 2 10 14 10.2106/JBJS.F.00019
3. Schmorl G, Junghanns H. The human spine in health and disease. Philadelphia:Grune and Stratton; 1971. pp 12-30.
4. N Boos S Weissbach H Rohrbach C Weiler KF Spratt AG Nerlich 2002 Classification of age-related changes in lumbar intervertebral discs Spine 27 2631 2644 10.1097/00007632-200212010-00002 12461389 (Pubitemid 35425317)
5. MB Coventry RK Ghormley JW Kernohan 1945 The intervertebral disc: Its microscopic anatomy and pathology: part 1, anatomy, development, and physiology J Bone Joint Surg 27A 105 112
6. WR Ferguson 1950 Some observations on the circulation in fetal and infant spines J Bone Joint Surg 32 640 648 15428487
7. HE Gruber EN Hanley Jr 1998 Analysis of aging and degeneration of the human intervertebral disc: comparison of surgical specimens with normal controls Spine 23 751 757 10.1097/00007632-199804010-00001 1:STN:280: DyaK1c3isVajtw%3D%3D 9563104 (Pubitemid 28169196)
8. M Rudert B Tillman 1993 Detection of lymphatic and blood vessels in the human intervertebral disc by histochemical and immunohistochemical methods Acta Orthop Scand 175 237 242 1:STN:280:DyaK3szjt1agtA%3D%3D
9. M Rudert B Tillmann 1993 Lymph and blood supply of the human intervertebral disc: cadaver study of correlations to discitis Acta Orthop Scand 64 37 40 1:STN:280:DyaK3s7pvVGnug%3D%3D 8451943
10. JR Taylor JE Scott AM Cribb TR Bosworth 1992 Human intervertebral disc acid glycosaminoglycans J Anat 180 137 141 1452468
11. JL Whalen WW Parke JM Mazur ES Stauffer 1985 The intrinsic vasculature of developing vertebral end plates and its nutritive significance to the intervertebral disc Paediat Orthop 5 403 410 1:STN:280:DyaL2M3mtF2gsw%3D%3D
12. B Vernon-Roberts RJ Moor RD Fraser 1996 The natural history of age-related disc degeneration: the pathology of sequelae of tears Spine 32 2797 2804 10.1097/BRS.0b013e31815b64d2
13. RJ Moore B Vernon-Roberts RD Fraser OL Osti M Schembri 1996 The origin and fate of herniated lumbar intervertebral disc tissue Spine 21 2149 2155 10.1097/00007632-199609150-00018 1:STN:280:DyaK2s%2FkvVKisg%3D%3D 8893441 (Pubitemid 26330602)
14. G Oliver 2004 Lymphatic vasculature development Nat Rev Immunol 4 35 45 10.1038/nri1258 1:CAS:528:DC%2BD2cXkvVCisw%3D%3D 14704766
15. JR Edwards K Williams LG Kindblom J Meis-Kindblom D Hughes P Hoogendorn D Jackson R Forsyth NA Athanasou 2008 Lymphatics and bone Human Pathol 39 49 55 10.1016/j.humpath.2007.04.022 (Pubitemid 350216159)
16. Ryan TJ. The lymphatics In: J.O'D McGee, PG Isaacson, N Wright, editors. Oxford Textbook of Pathology. Oxford:OUP; 1992. pp. 923-31.
17. Vigorita VJ. Orthopaedic pathology. Philadelphia:LWW; 2008. pp. 451-5.
18. JP Sleeman J Krishnan V Kirkin P Baumann 2001 Markers for the lymphatic endothelium: in search of the holy grail? Microsc Res Tech 55 61 69 10.1002/jemt.1157 1:STN:280:DC%2BD3MrkvFamsw%3D%3D 11596151 (Pubitemid 32988907)
19. S Banerji V Ni SX Wang S Clasper J Su R Tammi M Jones DG Jackson 1999 LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan J Cell Biol 144 789 801 10.1083/jcb.144.4.789 1:CAS:528:DyaK1MXhvVWmsLc%3D 10037799 (Pubitemid 29234556)
20. S Breiteneder-Geleff A Soleiman H Kowalski R Horvat G Amann E Kriehuber K Diem W Weninger E Tschachler K Alitalo D Kerjaschki 1999 Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium Am J Pathol 154 385 394 1:STN:280:DyaK1M7kvFKnsQ%3D%3D 10027397
21. A Lymboussaki TA Partanen B Olofsson J Thomas-Crusells CD Fletcher RM de Waal A Kaipainen K Alitalo 1998 Expression of the vascular endothelial growth factor C receptor VEGFR-3 in lymphatic endothelium of the skin and in vascular tumours Am J Pathol 153 395 403 1:CAS:528:DyaK1cXls1ejtr8%3D 9708800 (Pubitemid 28373651)
22. JT Wigle G Oliver 1999 Prox1 function is required for the development of the murine lymphatic system Cell 98 769 778 10.1016/S0092-8674(00)81511-1 1:CAS:528:DyaK1MXmt1Grs70%3D 10499794 (Pubitemid 29446894)
23. JA Werner M Schunke B Tillmann 1987 Histochemical visualisation of lymphatic capillaries in the rat: a comparison of methods demonstrated at the posterior pharyngeal surface Arch Histol Jpn 50 505 514 10.1679/aohc.50.505 1:STN:280:DyaL1c7kvFajsg%3D%3D 2830854
24. K Fujita T Nakagawa K Hirabayashi Y Nagai 1993 Neutral proteinases in human intervertebral disc: role in degeneration and probable origin Spine 18 1766 1773 10.1097/00007632-199310000-00009 1:STN:280:DyaK2c%2FlsVSjtA%3D%3D 8235859
25. JD Kang HI Georgescu L McIntyre-Larkin M Stefanovic-Racic WF Donaldson 3rd CH Evans 1996 Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2 Spine 21 271 277 10.1097/00007632-199602010-00003 1:STN:280:DyaK28zks1WrsQ%3D%3D 8742201 (Pubitemid 26056478)
26. CL Le Maitre AJ Freemont JA Hoyland 2004 Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc J Pathol 204 47 54 10.1002/path.1608 15307137 (Pubitemid 39214481)
27. J Liu PJ Roughley JA Mort 1991 Identification of human intervertebral disc stromelysin and its involvement in matrix degradation J Orthop Res 9 568 575 10.1002/jor.1100090413 1:CAS:528:DyaK3MXltFWiu7k%3D 1646316
28. R Sztrolovics M Alini PJ Roughly JA Mort 1997 Aggrecan degradation in human intervertebral disc and articular cartilage Biochem J 326 235 241 1:CAS:528:DyaK2sXlvFCht74%3D 9337874
29. CL Le Maitre AJ Freemont JA Hoyland 2005 The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration Arthritis Res Ther 7 R732 R745 10.1186/ar1732 15987475
30. K Olmarker K Larsson 1998 Tumour necrosis factor alpha and nucleus-pulposus-induced nerve root injury Spine 23 2538 2544 10.1097/00007632-199812010-00008 1:STN:280:DyaK1M%2FntF2itA%3D%3D 9854752 (Pubitemid 29003527)
31. S Roberts RC Butler 2005 Inflammatory mediators as potential therapeutic targets in the spine Curr Drug Targets Inflamm Allergy 4 257 266 10.2174/1568010053586372 1:CAS:528:DC%2BD2MXlsFelsbc%3D 15853748 (Pubitemid 40873108)
32. H Takahashi T Suguro Y Okazima M Motegi Y Okada T Kakiuchi 1996 Inflammatory cytokines in the herniated disc of the lumbar spine Spine 21 218 224 10.1097/00007632-199601150-00011 1:STN:280:DyaK28zmtFGqtA%3D%3D 8720407 (Pubitemid 26041220)
33. JR Salisbury 1993 The pathology of the human notochord J Pathol 17 253 255 10.1002/path.1711710404 (Pubitemid 24022985)