Female Sexual Dysfunction

Obstetrics and Gynecology Clinics of North America

Volumn 36, Issue 4, 2009, Pages 861-876

  Clayton, Anita H ^a   Hamilton, David V ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Female sexual arousal disorder; Female sexual dysfunction; Hypoactive sexual desire disorder; Sexual disorders

Indexed keywords

AMFEBUTAMONE; ESTRADIOL PLUS NORETHISTERONE ACETATE; ESTROGEN; GESTAGEN; LUBRICATING AGENT; PLACEBO; PROGESTERONE; SILDENAFIL; TESTOSTERONE; TIBOLONE;

ACNE; CLINICAL TRIAL; COGNITIVE THERAPY; CULTURAL FACTOR; DOSE RESPONSE; DYSPAREUNIA; FEMALE; FEMALE SEXUAL DYSFUNCTION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC ASSOCIATION; HIRSUTISM; HUMAN; HYPOACTIVE SEXUAL DESIRE DISORDER; INCIDENCE; LOW DRUG DOSE; MENOPAUSAL SYNDROME; MENOPAUSE; ORGASM DISORDER; POSITRON EMISSION TOMOGRAPHY; PREVALENCE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SEXOLOGY; SEXUAL AROUSAL DISORDER; SEXUAL BEHAVIOR; SEXUAL DYSFUNCTION; VAGINA ATROPHY; VAGINISM;

FEMALE; HUMANS; SEXUAL DYSFUNCTION, PHYSIOLOGICAL; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL; SEXUALITY;

EID: 70450197627     PISSN: 08898545     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ogc.2009.10.002     Document Type: Review

References (76)

1. Kinsey A. Sexual behavior in the human female (1953), Saunders, Philadelphia
2. Sand M., and Fisher W.A. Women's endorsement of models of female sexual response: the nurses' sexuality study. J Sex Med 4 (2007) 708-719
3. Braunstein G.D. Androgen insufficiency in women: summary of critical issues. Fertil Steril 77 Suppl 4 (2002) S94-S99
4. Hull E.M., Eaton R.C., Moses J., et al. Copulation increases dopamine activity in the medial preoptic area of male rats. Life Sci 52 (1993) 935-940
5. Segraves R.T. Effects of psychotropic drugs on human erection and ejaculation. Arch Gen Psychiatry 46 (1989) 275-284
6. Lee A.W., and Pfaff D.W. Hormone effects on specific and global brain functions. J Physiol Sci 58 4 (2008) 213-220
7. Done C.J., and Sharp T. Evidence that 5-HT2 receptor activation decreases noradrenaline release in rat hippocampus in vivo. Br J Pharmacol 107 (1992) 240-245
8. Frolich P.F., and Meston C.M. Evidence that serotonin affects female sexual functioning via peripheral mechanisms. Physiol Behav 71 (2000) 383-393
9. Watson N.V., and Gorzalka B.B. Concurrent wet dog shaking and inhibition of male rat copulation after ventromedial brainstem injection of the 5-HT2 agonist DOI. Neurosci Lett 141 (1992) 25-29
10. D'Amati G., di Gioia C.R.T., Bologna M., et al. Type 5 phosphodiesterase expression in the human vagina. Urology 60 (2002) 191-195
11. Palle C., Bredkajer H.E., Ottesen B., et al. Vasoactive intestinal polypeptide in human vaginal blood flow: comparison between transvaginal and intravenous administration. Clin Exp Pharmacol Physiol 17 (1990) 61-68
12. Marin R., Escrig A., Abreu P., et al. Androgen-dependent nitric oxide release in rat penis correlates with levels of constitutive nitric oxide synthetase isoenzymes. Biol Reprod 61 (2002) 1012-1016
13. Giuliano F., Allard J., Compagnie S., et al. Vaginal physiological changes in a model of sexual arousal in anesthetized rats. Am J Physiol Regul Integr Comp Physiol 281 1 (2001) R140-R149
14. Kruger T.H., Hartmann U., and Schedlowski M. Prolactinergic and dopaminergic mechanisms underlying sexual arousal and orgasm in humans. World J Urol 23 2 (2005) 130-138
15. Stahl S.M. The psychopharmacology of sex, part 2, effects of drugs and disease on the 3 phases of human sexual response. J Clin Psychiatry 62 3 (2001) 147-148
16. Clayton A., and Ramamurthy S. The impact of physical illness on sexual dysfunction. Balon R, editor. Sexual Dysfunction: the brain body connection. Adv Psychosom Med. Basel: Karger; 2008 (2008) p. 70-88
17. Montejo A.L., Llorca G., Izquierdo J.A., et al. Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. J Clin Psychiatry 62 Suppl 3 (2001) 10-21
18. Clayton A.H., Pradko J.F., Croft H.A., et al. Prevalence of sexual dysfunction among newer antidepressants. J Clin Psychiatry 63 (2002) 357-366
19. Clayton A., Kornstein S., Prakash A., et al. Changes in sexual functioning associated with duloxetine, escitalopram and placebo in the treatment of patients with major depressive disorder. J Sex Med 4 (2007) 917-929
20. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th edition. Text revision (2000), American Psychiatric Association, Washington, DC
21. Nusbaum M.R.H., Helton M.R., and Ray N. The changing nature of women's sexual health concerns through the midlife years. Maturitas 49 (2004) 283-291
22. Bancroft J., Loftus J., and Long J.S. Distress about sex: a national survey of women in heterosexual relationships. Arch Sex Behav 32 (2003) 193-208
23. Derogatis L.R., and Burnett A.L. The epidemiology of sexual dysfunctions. J Sex Med 5 2 (2008) 289-300
24. Hayes R.D., Dennerstein L., Bennett C.M., et al. Relationship between hypoactive sexual desire disorder and aging. Fertil Steril 87 1 (2007) 107-112
25. Shifren J.L., Monz B.U., Russo P.A., et al. Sexual problems and distress in United States women. Obstet Gynecol 112 5 (2008) 970-978
26. Arnow B.A., Millheiser L., Garrett A., et al. Women with hypoactive sexual desire disorder compared to normal females: a functional magnetic resonance imaging study. Neuroscience 158 (2009) 484-502
27. Georgiadis J.R., Kortekaas R., Kuipers R., et al. Regional cerebral blood flow changes associated with clitorally induced orgasm in healthy women. Eur J Neurosci 24 (2006) 3305-3316
28. Komisaruk B.R., Whipple B., Crawford A., et al. Brain activity (fMRI and PET) during orgasm in women, in response to vaginocervical self-stimulation. Abstr Soc Neurosci 841 (2002) 17
29. Dunn K.M., Cherkas L.F., and Spector T.D. Genetic influences on variation in female orgasmic function: a twin study. Biol Lett 1 3 (2005) 260-263
30. Dawood K., Kirk K.M., Bailey J.M., et al. Genetic and environmental influences on the frequency of orgasm in women. Twin Res Hum Genet 9 4 (2006) 603-608
31. Wallen K., and Lloyd E.A. Clitoral variability compared with penile variability supports nonadaptation of female orgasm. Evol Dev 10 1 (2008) 1-2
32. Bishop J.R., Moline J., Ellingrod V.L., et al. Serotonin 2A-1438 G-A and G-protein beta3 subunit C825T polymorphisms in patients with depression and SSRI-associated sexual side effects. Neuropsychopharmacology 31 (2006) 2281-2288
33. Bishop J.R., Ellingrod V.L., Akroush M., et al. The association of serotonin transporter genotypes and selective serotonin reuptake inhibitor (SSRI)-associated sexual side effects: possible relationship to oral contraceptives. Hum Psychopharmacol 24 (2009) 207-215
34. Ben Zion I.Z., Tessler R., Cohen L., et al. Polymorphisms in the dopamine D4 receptor gene (DRD4) contribute to individual differences in human sexual behavior: desire arousal, and sexual function. Mol Psychiatry 11 8 (2006) 782-786
35. Leiblum S.R., Koochaki P.E., Rodenberg C.A., et al. Sexual desire disorder in postmenopausal women: US results from the Women's International Study of Health and Sexuality (WISHeS). Menopause 13 1 (2006) 46-56
36. Clayton A.H., Goldfischer E.R., Goldstein I., et al. Validation of the decreased sexual desire screener (DSDS): a brief diagnostic instrument for generalized acquired female hypoactive sexual desire disorder (HSDD). J Sex Med 6 (2009) 730-738
37. Goldfischer E.R., Clayton A.H., Goldstein I., et al. Decreased sexual desire screener (DSDS) for diagnosis of hypoactive sexual desire disorder in women. Obstet Gynecol 111 (2008) 109
38. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th edition, text revision. Washington, DC: American Psychiatric Association; 2000. p. 543, 549, 556, 558.
39. Quirk F., Haughie S., and Symonds T. The use of the sexual function questionnaire as a screening tool for women with sexual dysfunction. J Sex Med 2 (2005) 469-477
40. Sand M, Rosen R, Meston C, et al. The female sexual function index (FSFI): a potential "gold standard" measure for assessing sexual function in women, Poster 24, 3rd International Consultation on Sexual Medicine, Paris, July 10-13, 2009.
41. Levin R.J. Sexual desire and the deconstruction and reconstruction of the human female response model of Masters and Johnson. In: Everaerd W., Laan E., and Both S. (Eds). Sexual appetite, desire and motivation: energetics of the sexual system (2001), Royal Netherlands Academy of Arts and Sciences, Amsterdam (The Netherlands) 63-93
42. Gregersen N., Jensen P.T., and Giraldi A.G.E. Sexual dysfunction in the peri- and postmenopause. Status of incidence, pharmacological treatment and possible risks. A secondary publication. Dan Med Bull 53 3 (2006) 349-353
43. Avis N.E., Zhao X., Johannes C.B., et al. Correlates of sexual function among multi-ethnic middle-aged women: results from the Study of Women's Health Across the Nation (SWAN). Menopause 12 4 (2005) 385-398
44. Arroyo A., and Yeh J. Understanding the menopause transition and managing its clinical challenges. Sex Reprod Menopause 3 (2006) 12-7
45. Weismiller D. The perimenopause and menopause experience: an overview. Clin Geriatr Med 20 (2003) 565-570
46. Hall J. Neuroendocrine physiology of the early and late menopause. Endocrinol Metab Clin North Am 33 (2004) 637-659
47. Wilson M.M. Menopause. Clin Geriatr Med 19 3 (2003) 483-506
48. Laan E., and van Lunsen R.H. Hormones and sexuality in postmenopausal women: a psychophysiological study. J Psychosom Obstet Gynaecol 18 2 (1997) 126-133
49. Phillips N.A. Female sexual dysfunction: evaluation and treatment. Am Fam Physician 62 1 (2000) 127-136 141-2
50. Bachmann G., Bancroft J., Braunstein G., et al. Female androgen insufficiency: the Princeton consensus statement on definition, classification, and assessment. Fertil Steril 77 4 (2002) 660-665
51. Bachmann G.A., and Leiblum S.R. The impact of hormones on menopausal sexuality: a literature review. Menopause 11 (2004) 120-130
52. Dennerstein L., Alexander J.L., and Kotz K. The menopause and sexual functioning: a review of the population-based studies. Annu Rev Sex Res 14 (2003) 64-82
53. Dennerstein L., Lehert P., and Burger H. The relative effects of hormones and relationship factors on sexual function of women through the natural menopausal transition. Fertil Steril 84 1 (2005) 174-180
54. Heiman J.R. Orgasmic disorders in women. In: Leiblum S.R., and Rosen R.C. (Eds). Principles and practice of sex therapy. 3rd edition (2000), Guildford Press, New York p. 84-123
55. McMullen S., and Rosen R.C. Self-administered masturbation training in the treatment of primary orgasmic dysfunction. J Consult Clin Psychol 47 (1979) 912-918
56. McCabe M.P. Evaluation of a cognitive behavioral therapy program for people with sexual dysfunction. J Sex Marital Ther 27 (2001) 259-271
57. Shields K.M., and Hrometz S.L. Use of sildenafil for female sexual dysfunction. Ann Pharmacother 40 5 (2006) 931-934
58. Nurnberg H.G., Hensley P.L., Heiman J.R., et al. Sildenafil treatment of women with antidepressant-associated sexual dysfunction: a randomized controlled trial. JAMA 300 4 (2008) 395-404
59. Segraves R.T., Croft H., Kavoussi R., et al. Bupropion sustained release (SR) for the treatment of hypoactive sexual desire disorder (HSDD) in nondepressed women. J Sex Marital Ther 27 3 (2001) 303-316
60. Modell J.G., May R.S., and Katholi C.R. Effect of bupropion-SR on orgasmic dysfunction in nondepressed subjects: a pilot study. J Sex Marital Ther 26 3 (2000) 231-240
61. Seagraves RT, Clayton AH, Croft H, et al. A multicenter, double-blind, placebo-controlled study of bupropion XL in females with orgasm disorder. Abstracts of the 19th Annual U.S. Psychiatric & Mental Health Congress, November, 2006.
62. Clayton A.H., Warnock J.K., Kornstein S.G., et al. A placebo-controlled trial of bupropion SR as an antidote for selective serotonin reuptake inhibitor-induced sexual dysfunction. J Clin Psychiatry 65 (2004) 62-67
63. Nelson H., Haney H., Miller J., et al. Management of menopause-related symptoms: summary. (Evidence Rep Technology Assessment No. 120, AHQR Publ. No. 05-E016-1), Rockville (MD): agency for Healthcare Research and Quality. As cited by Petersen M. In: Tepper M.S., and Owens A.F. (Eds). Menopause and sexuality in sexual health (2007), Praeger Press, Westport (CT)
64. Rossouw J.E., Prentice R.L., Manson J.E., et al. Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause. JAMA 297 13 (2007) 1465-1477
65. Wassertheil-Smoller S., Hendrix S.L., Limacher M., et al. Effect of estrogen plus progestin on stroke in postmenopausal women: the Women's Health Initiative: a randomized trial. JAMA 289 20 (2003) 2673-2684
66. Rossouw J.E., Anderson G.L., Prentice R.L., et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288 3 (2002) 321-333
67. Dennerstein G. Re: hormones down under: hormone therapy use after the women's health initiative. Aust N Z J Obstet Gynaecol 47 1 (2006) 80
68. Modelska K., and Cummings S. Female sexual dysfunction in postmenopausal women: systematic review of placebo-controlled trials. Am J Obstet Gynecol 188 1 (2003) 286-293
69. Sherwin B.B. The impact of different doses of estrogen and progestin on mood and sexual behavior in postmenopausal women. J Clin Endocrinol Metab 72 (1991) 336-343
70. Vestergaard P., Hermann A.P., Stilgren L., et al. Effects of 5 years of hormonal replacement therapy on menopausal symptoms and blood pressure-a randomised controlled study. Maturitas 46 2 (2003) 123-132
71. North American Menopause Society. The role of local vaginal estrogen for treatment of vaginal atrophy in postmenopausal women: 2007 position statement of The North American Menopause Society. Menopause 14 3 Pt 1 (2007) 355-369
72. Shifren J.L., Desindes S., McIlwain M., et al. A randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women. Menopause 14 6 (2007) 985-994
73. Braunstein G.D., Sundwall D.A., Katz M., et al. Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Arch Intern Med 165 14 (2005) 1582-1589
74. Buster J.E., Kingsberg S.A., Aguirre O., et al. Testosterone patch for low sexual desire in surgically menopausal women: a randomized trial. Obstet Gynecol 105 (2005) 944-952
75. Wu M.H., Pan H.A., Wang S.T., et al. Quality of life and sexuality changes in postmenopausal women receiving tibolone therapy. Climacteric 4 4 (2001) 314-319
76. Nijland E.A., Weijmar Schultz W.C., Nathorst-Boos J., et al. Tibolone and transdermal E2/NETA for the treatment of female sexual dysfunction in naturally menopausal women: results of a randomized active-controlled trial. J Sex Med 5 3 (2008) 646-656