메뉴 건너뛰기




Volumn 14, Issue 6, 2007, Pages 985-994

A randomized, open-label, crossover study comparing the effects of oral versus transdermal estrogen therapy on serum androgens, thyroid hormones, and adrenal hormones in naturally menopausal women

Author keywords

Adrenal; Androgen; Estrogen; Menopause; Thyroid; Transdermal

Indexed keywords

ANDROGEN; CONJUGATED ESTROGEN; ESTRADIOL; HYDROCORTISONE; PROGESTERONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; THYROID HORMONE; THYROXINE; THYROXINE BINDING GLOBULIN;

EID: 36048982140     PISSN: 10723714     EISSN: None     Source Type: Journal    
DOI: 10.1097/gme.0b013e31803867a     Document Type: Article
Times cited : (79)

References (52)
  • 1
    • 1842590509 scopus 로고    scopus 로고
    • Commonly used types of postmenopausal estrogen for treatment of hot flashes: Scientific review
    • Nelson HD. Commonly used types of postmenopausal estrogen for treatment of hot flashes: scientific review. JAMA 2004;291:1610-1620.
    • (2004) JAMA , vol.291 , pp. 1610-1620
    • Nelson, H.D.1
  • 2
    • 0033102731 scopus 로고    scopus 로고
    • Comparison of Alora estradiol matrix transdermal delivery system with oral conjugated equine estrogen therapy in relieving menopausal symptoms. Alora Study Group
    • Good WR, John VA, Ramirez M, Higgins JE. Comparison of Alora estradiol matrix transdermal delivery system with oral conjugated equine estrogen therapy in relieving menopausal symptoms. Alora Study Group. Climacteric 1999;2:29-36.
    • (1999) Climacteric , vol.2 , pp. 29-36
    • Good, W.R.1    John, V.A.2    Ramirez, M.3    Higgins, J.E.4
  • 3
    • 0033809982 scopus 로고    scopus 로고
    • Prevention of postmenopausal osteoporosis with oestrogen replacement therapy and associated compounds: Update on clinical trials since 1995
    • Doren M, Samsioe G. Prevention of postmenopausal osteoporosis with oestrogen replacement therapy and associated compounds: update on clinical trials since 1995. Hum Reprod Update 2000;6:419-426.
    • (2000) Hum Reprod Update , vol.6 , pp. 419-426
    • Doren, M.1    Samsioe, G.2
  • 4
    • 0036729051 scopus 로고    scopus 로고
    • Effectiveness of Alora estradiol matrix transdermal delivery system in improving lumbar bone mineral density in healthy, postmenopausal women
    • Notelovitz M, John VA, Good WR. Effectiveness of Alora estradiol matrix transdermal delivery system in improving lumbar bone mineral density in healthy, postmenopausal women. Menopause 2002;9:343-353.
    • (2002) Menopause , vol.9 , pp. 343-353
    • Notelovitz, M.1    John, V.A.2    Good, W.R.3
  • 6
    • 0026014605 scopus 로고
    • Comparison of transdermal to oral estradiol administration on hormonal and hepatic parameters in women with premature ovarian failure
    • Steingold KA, Matt DW, DeZiegler D, Sealey JE, Fratkin M, Reznikov S. Comparison of transdermal to oral estradiol administration on hormonal and hepatic parameters in women with premature ovarian failure. J Clin Endocrinol Metab 1991;73:275-280.
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 275-280
    • Steingold, K.A.1    Matt, D.W.2    DeZiegler, D.3    Sealey, J.E.4    Fratkin, M.5    Reznikov, S.6
  • 7
    • 0018934989 scopus 로고
    • Biological effects of various doses of conjugated equine estrogens in postmenopausal women
    • Geola FL, Frumar AM, Tataryn IV, et al. Biological effects of various doses of conjugated equine estrogens in postmenopausal women. J Clin Endocrinol Metab 1980;51:620-625.
    • (1980) J Clin Endocrinol Metab , vol.51 , pp. 620-625
    • Geola, F.L.1    Frumar, A.M.2    Tataryn, I.V.3
  • 8
    • 2342539034 scopus 로고    scopus 로고
    • Interaction of estrogen therapy and thyroid hormone replacement in postmenopausal women
    • Mazer NA. Interaction of estrogen therapy and thyroid hormone replacement in postmenopausal women. Thyroid 2004;14(Suppl 1):S27-S34.
    • (2004) Thyroid , vol.14 , Issue.SUPPL. 1
    • Mazer, N.A.1
  • 9
    • 36049003154 scopus 로고    scopus 로고
    • Effect of estrogen replacement therapy on testosterone levels in women: Differences between oral and transdermal routes of administration
    • September:10-13
    • Mazer NA. Effect of estrogen replacement therapy on testosterone levels in women: differences between oral and transdermal routes of administration. Suppl OBG Manage 2001;September:10-13.
    • (2001) Suppl OBG Manage
    • Mazer, N.A.1
  • 10
    • 0024430817 scopus 로고
    • The free hormone hypothesis: A physiologically based mathematical model
    • Mendel CM. The free hormone hypothesis: a physiologically based mathematical model. Endocr Rev 1989;10:232-274.
    • (1989) Endocr Rev , vol.10 , pp. 232-274
    • Mendel, C.M.1
  • 11
    • 0034618866 scopus 로고    scopus 로고
    • Transdermal testosterone treatment in women with impaired sexual function after oophorectomy
    • Shifren JL, Braunstein GD, Simon JA, et al. Transdermal testosterone treatment in women with impaired sexual function after oophorectomy. N Engl J Med 2000;343:682-688.
    • (2000) N Engl J Med , vol.343 , pp. 682-688
    • Shifren, J.L.1    Braunstein, G.D.2    Simon, J.A.3
  • 13
    • 36049021064 scopus 로고    scopus 로고
    • 1) and cortisol (C) in men and women. In: The Endocrine Society: Program and Abstracts 88th Annual Meeting, June 24-27, Boston, MA. Chevy Chase, MD: Endocrine Society Press, 2004:536. Poster P2-551.
    • 1) and cortisol (C) in men and women. In: The Endocrine Society: Program and Abstracts 88th Annual Meeting, June 24-27, Boston, MA. Chevy Chase, MD: Endocrine Society Press, 2004:536. Poster P2-551.
  • 15
    • 0003139708 scopus 로고
    • Robust tests for equality of variances
    • Olkin I, Ghurye SG, Hoeffding W, Madow WG, Mann HB, eds, Stanford, CA: Stanford University Press
    • Levene H. Robust tests for equality of variances. In: Olkin I, Ghurye SG, Hoeffding W, Madow WG, Mann HB, eds. Contributions to Probability and Statistics. Stanford, CA: Stanford University Press, 1960:278-292.
    • (1960) Contributions to Probability and Statistics , pp. 278-292
    • Levene, H.1
  • 16
    • 0000898845 scopus 로고
    • An analysis of variance test for normality (complete samples)
    • Shapiro SS, Wilk MB. An analysis of variance test for normality (complete samples). Biometrika 1965;52:591-611.
    • (1965) Biometrika , vol.52 , pp. 591-611
    • Shapiro, S.S.1    Wilk, M.B.2
  • 17
    • 70449541670 scopus 로고
    • The two-period change-over design and its use in clinical trials
    • Grizzle JE. The two-period change-over design and its use in clinical trials. Biometrics 1965;21:467-480.
    • (1965) Biometrics , vol.21 , pp. 467-480
    • Grizzle, J.E.1
  • 18
    • 0024521543 scopus 로고
    • A concordance correlation coefficient to evaluate reproducibility
    • Lin LI. A concordance correlation coefficient to evaluate reproducibility. Biometrics 1989;45:255-268.
    • (1989) Biometrics , vol.45 , pp. 255-268
    • Lin, L.I.1
  • 19
    • 0033198821 scopus 로고    scopus 로고
    • Micronized progesterone: Clinical indications and comparison with current treatments
    • Fitzpatrick LA, Good A. Micronized progesterone: clinical indications and comparison with current treatments. Fertil Steril 1999;72:389-397.
    • (1999) Fertil Steril , vol.72 , pp. 389-397
    • Fitzpatrick, L.A.1    Good, A.2
  • 21
    • 0027730324 scopus 로고
    • Differential effects of oral conjugated estrogens and transdermal estradiol on insulin-like growth factor 1, growth hormone and sex hormone binding globulin serum levels
    • Campagnoli C, Biglia N, Altare F, et al. Differential effects of oral conjugated estrogens and transdermal estradiol on insulin-like growth factor 1, growth hormone and sex hormone binding globulin serum levels. Gynecol Endocrinol 1993;7:251-258.
    • (1993) Gynecol Endocrinol , vol.7 , pp. 251-258
    • Campagnoli, C.1    Biglia, N.2    Altare, F.3
  • 22
    • 0034727702 scopus 로고    scopus 로고
    • Differential effects of oral and transdermal estrogen replacement therapy on endothelial function in postmenopausal women
    • Vehkavaara S, Hakala-Ala-Pietila T, Virkamaki A, et al. Differential effects of oral and transdermal estrogen replacement therapy on endothelial function in postmenopausal women. Circulation 2000;102:2687-2693.
    • (2000) Circulation , vol.102 , pp. 2687-2693
    • Vehkavaara, S.1    Hakala-Ala-Pietila, T.2    Virkamaki, A.3
  • 23
    • 0035698572 scopus 로고    scopus 로고
    • Long-term effects of continuous oral and transdermal estrogen replacement therapy on sex hormone binding globulin and free testosterone levels
    • Serin IS, Ozcelik B, Basbug M, Aygen E, Kula M, Erez R. Long-term effects of continuous oral and transdermal estrogen replacement therapy on sex hormone binding globulin and free testosterone levels. Eur J Obstet Gynecol Reprod Biol 2001;99:222-225.
    • (2001) Eur J Obstet Gynecol Reprod Biol , vol.99 , pp. 222-225
    • Serin, I.S.1    Ozcelik, B.2    Basbug, M.3    Aygen, E.4    Kula, M.5    Erez, R.6
  • 25
    • 0029130862 scopus 로고
    • Circulating hormone levels in menopausal women receiving different hormone replacement therapy regimens. A comparison
    • Castelo-Branco C, Martinez de Osaba MJ, Fortuny A, Iglesias X, Gonzalez-Merlo J. Circulating hormone levels in menopausal women receiving different hormone replacement therapy regimens. A comparison. J Reprod Med 1995;40:556-560.
    • (1995) J Reprod Med , vol.40 , pp. 556-560
    • Castelo-Branco, C.1    Martinez de Osaba, M.J.2    Fortuny, A.3    Iglesias, X.4    Gonzalez-Merlo, J.5
  • 26
    • 0030065996 scopus 로고    scopus 로고
    • Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women
    • Raisz LG, Wiita B, Artis A, et al. Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women. J Clin Endocrinol Metab 1996;81:37-43.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 37-43
    • Raisz, L.G.1    Wiita, B.2    Artis, A.3
  • 27
    • 0029803081 scopus 로고    scopus 로고
    • Effects of hormonal replacement therapy on plasma sex hormone-binding globulin, androgen and insulin-like growth factor-1 levels in postmenopausal women
    • Stomati M, Hartmann B, Spinetti A, et al. Effects of hormonal replacement therapy on plasma sex hormone-binding globulin, androgen and insulin-like growth factor-1 levels in postmenopausal women. J Endocrinol Invest 1996;19:535-541.
    • (1996) J Endocrinol Invest , vol.19 , pp. 535-541
    • Stomati, M.1    Hartmann, B.2    Spinetti, A.3
  • 28
    • 0034488867 scopus 로고    scopus 로고
    • Associations among oral estrogen use, free testosterone concentration, and lean body mass among postmenopausal women
    • Gower BA, Nyman L. Associations among oral estrogen use, free testosterone concentration, and lean body mass among postmenopausal women. J Clin Endocrinol Metab 2000;85:4476-4480.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4476-4480
    • Gower, B.A.1    Nyman, L.2
  • 29
    • 0035821989 scopus 로고    scopus 로고
    • Increased need for thyroxine in women with hypothyroidism during estrogen therapy
    • Arafah BM. Increased need for thyroxine in women with hypothyroidism during estrogen therapy. N Engl J Med 2001;344:1743-1749.
    • (2001) N Engl J Med , vol.344 , pp. 1743-1749
    • Arafah, B.M.1
  • 31
    • 0031821952 scopus 로고    scopus 로고
    • Estrogen replacement therapy modulates spontaneous GH secretion but does not affect GH-RH-induced GH response and low T3 syndrome in women with hypothalamic amenorrhea associated to weight-loss
    • Genazzani AD, Gamba O, Petraglia F. Estrogen replacement therapy modulates spontaneous GH secretion but does not affect GH-RH-induced GH response and low T3 syndrome in women with hypothalamic amenorrhea associated to weight-loss. J Endocrinol Invest 1998;21:353-357.
    • (1998) J Endocrinol Invest , vol.21 , pp. 353-357
    • Genazzani, A.D.1    Gamba, O.2    Petraglia, F.3
  • 32
    • 18844396816 scopus 로고    scopus 로고
    • Tibolone, transdermal estradiol or oral estrogen-progestin therapies: Effects on circulating allopregnanolone, cortisol and dehydroepiandrosterone levels
    • Pluchino N, Genazzani AD, Bernardi F, et al. Tibolone, transdermal estradiol or oral estrogen-progestin therapies: effects on circulating allopregnanolone, cortisol and dehydroepiandrosterone levels. Gynecol Endocrinol 2005;20:144-149.
    • (2005) Gynecol Endocrinol , vol.20 , pp. 144-149
    • Pluchino, N.1    Genazzani, A.D.2    Bernardi, F.3
  • 33
    • 0031891893 scopus 로고    scopus 로고
    • Postmenopausal hormone replacement: Effects on autonomic, neuroendocrine, and immune reactivity to brief psychological stressors
    • Burleson MH, Malarkey WB, Cacioppo JT, et al. Postmenopausal hormone replacement: effects on autonomic, neuroendocrine, and immune reactivity to brief psychological stressors. Psychosom Med 1998;60:17-25.
    • (1998) Psychosom Med , vol.60 , pp. 17-25
    • Burleson, M.H.1    Malarkey, W.B.2    Cacioppo, J.T.3
  • 35
    • 0036280099 scopus 로고    scopus 로고
    • Effects of the route of estrogen administration and exercise on hormonal levels in postmenopausal women
    • Williams CD, Dobridge JD, Meyer WR, Hackney AC. Effects of the route of estrogen administration and exercise on hormonal levels in postmenopausal women. Fertil Steril 2002;77:1118-1124.
    • (2002) Fertil Steril , vol.77 , pp. 1118-1124
    • Williams, C.D.1    Dobridge, J.D.2    Meyer, W.R.3    Hackney, A.C.4
  • 36
    • 0342621700 scopus 로고    scopus 로고
    • Psychological and endocrine responses to psychosocial stress and dexamethasone/corticotropin-releasing hormone in healthy postmenopausal women and young controls: The impact of age and a two-week estradiol treatment
    • Kudielka BM, Schmidt-Reinwald AK, Hellhammer DH, Kirschbaum C. Psychological and endocrine responses to psychosocial stress and dexamethasone/corticotropin-releasing hormone in healthy postmenopausal women and young controls: the impact of age and a two-week estradiol treatment. Neuroendocrinology 1999;70:422-430.
    • (1999) Neuroendocrinology , vol.70 , pp. 422-430
    • Kudielka, B.M.1    Schmidt-Reinwald, A.K.2    Hellhammer, D.H.3    Kirschbaum, C.4
  • 37
    • 0034967169 scopus 로고    scopus 로고
    • Estrogen modulates the hypothalamic-pituitary-adrenal and inflammatory cytokine responses to endotoxin in women
    • Puder JJ, Freda PU, Goland RS, Wardlaw SL. Estrogen modulates the hypothalamic-pituitary-adrenal and inflammatory cytokine responses to endotoxin in women. J Clin Endocrinol Metab 2001;86:2403-2408.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2403-2408
    • Puder, J.J.1    Freda, P.U.2    Goland, R.S.3    Wardlaw, S.L.4
  • 38
    • 0036177222 scopus 로고    scopus 로고
    • Estrogen treatment and body fat distribution are involved in corticotropin and cortisol response to corticotropin-releasing hormone in postmenopausal women
    • Cucinelli F, Soranna L, Barini A, et al. Estrogen treatment and body fat distribution are involved in corticotropin and cortisol response to corticotropin-releasing hormone in postmenopausal women. Metabolism 2002;51:137-143.
    • (2002) Metabolism , vol.51 , pp. 137-143
    • Cucinelli, F.1    Soranna, L.2    Barini, A.3
  • 40
    • 0028136571 scopus 로고
    • Hormonal and metabolic effects of transdermal estradiol/progestagen administration in postmenopausal women
    • Perrone G, Falaschi P, Capri O, et al. Hormonal and metabolic effects of transdermal estradiol/progestagen administration in postmenopausal women. Int J Fertil Menopausal Stud 1994;39:202-207.
    • (1994) Int J Fertil Menopausal Stud , vol.39 , pp. 202-207
    • Perrone, G.1    Falaschi, P.2    Capri, O.3
  • 42
    • 0018534303 scopus 로고
    • Transport of protein-bound steroid hormones into liver in vivo
    • Pardridge WM, Mietus LJ. Transport of protein-bound steroid hormones into liver in vivo. Am J Physiol 1979;237:E367-E372.
    • (1979) Am J Physiol , vol.237
    • Pardridge, W.M.1    Mietus, L.J.2
  • 43
    • 0023112071 scopus 로고
    • Free estradiol, free testosterone, and sex hormone-binding globulin in perimenopausal women
    • Longcope C, Hui SL, Johnston CC Jr. Free estradiol, free testosterone, and sex hormone-binding globulin in perimenopausal women. J Clin Endocrinol Metab 1987;64:513-518.
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 513-518
    • Longcope, C.1    Hui, S.L.2    Johnston Jr., C.C.3
  • 44
    • 0023392224 scopus 로고
    • Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine-binding globulin
    • Bianchi R, Iervasi G, Pilo A, et al. Role of serum carrier proteins in the peripheral metabolism and tissue distribution of thyroid hormones in familial dysalbuminemic hyperthyroxinemia and congenital elevation of thyroxine-binding globulin. J Clin Invest 1987;80:522-534.
    • (1987) J Clin Invest , vol.80 , pp. 522-534
    • Bianchi, R.1    Iervasi, G.2    Pilo, A.3
  • 45
    • 0028941753 scopus 로고
    • Corticosteroid-binding globulin influences kinetic parameters of plasma cortisol transport and clearance
    • Bright GM. Corticosteroid-binding globulin influences kinetic parameters of plasma cortisol transport and clearance. J Clin Endocrinol Metab 1995;80:770-775.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 770-775
    • Bright, G.M.1
  • 46
    • 0036227440 scopus 로고    scopus 로고
    • Testosterone deficiency in women: Etiologies, diagnosis, and emerging treatments
    • Mazer NA. Testosterone deficiency in women: etiologies, diagnosis, and emerging treatments. Int J Fertil Womens Med 2002;47:77-86.
    • (2002) Int J Fertil Womens Med , vol.47 , pp. 77-86
    • Mazer, N.A.1
  • 47
    • 0018346591 scopus 로고
    • Metabolic clearance rate and interconversion of androgens and the influence of the free androgen fraction
    • Vermeulen A, Ando S. Metabolic clearance rate and interconversion of androgens and the influence of the free androgen fraction. J Clin Endocrinol Metab 1979;48:320-326.
    • (1979) J Clin Endocrinol Metab , vol.48 , pp. 320-326
    • Vermeulen, A.1    Ando, S.2
  • 48
    • 23744457446 scopus 로고    scopus 로고
    • Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: A randomized, placebo-controlled trial
    • Braunstein GD, Sundwall DA, Katz M, et al. Safety and efficacy of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Arch Intern Med 2005;165:1582-1589.
    • (2005) Arch Intern Med , vol.165 , pp. 1582-1589
    • Braunstein, G.D.1    Sundwall, D.A.2    Katz, M.3
  • 49
    • 33645963994 scopus 로고    scopus 로고
    • Effects of aromatase inhibition on sexual function and well-being in postmenopausal women treated with testosterone: A randomized, placebo-controlled trial
    • Davis SR, Goldstat R, Papalia MA, et al. Effects of aromatase inhibition on sexual function and well-being in postmenopausal women treated with testosterone: a randomized, placebo-controlled trial. Menopause 2006;13:37-45.
    • (2006) Menopause , vol.13 , pp. 37-45
    • Davis, S.R.1    Goldstat, R.2    Papalia, M.A.3
  • 50
    • 33745231170 scopus 로고    scopus 로고
    • Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: A randomized, placebo-controlled trial
    • Davis SR, van der Mooren MJ, van Lunsen RH, et al. Efficacy and safety of a testosterone patch for the treatment of hypoactive sexual desire disorder in surgically menopausal women: a randomized, placebo-controlled trial. Menopause 2006;13:387-396.
    • (2006) Menopause , vol.13 , pp. 387-396
    • Davis, S.R.1    van der Mooren, M.J.2    van Lunsen, R.H.3
  • 51
    • 33646011552 scopus 로고    scopus 로고
    • Is testosterone or estradiol the hormone of desire? A novel study of the effects of testosterone treatment and aromatase inhibition in postmenopausal women
    • Shifren JL. Is testosterone or estradiol the hormone of desire? A novel study of the effects of testosterone treatment and aromatase inhibition in postmenopausal women. Menopause 2006;13:8-9.
    • (2006) Menopause , vol.13 , pp. 8-9
    • Shifren, J.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.