Determination of pKa values of nonsteroidal antiinflammatory drug-oxicams by RP-HPLC and their analysis in pharmaceutical dosage forms

Journal of Separation Science

Volumn 32, Issue 17, 2009, Pages 2928-2936

  Demiralay, Ebru Cubuk ^a   Alsancak, Guleren ^a   Ozkan, Sibel A ^b  

^a SULEYMAN DEMIREL UNIVERSITY   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

Author keywords

Determination; Method validation; Oxicams; Pharmaceutical dosage forms; pK a

Indexed keywords

CAPACITY FACTORS; CHROMATOGRAPHIC DETERMINATION; CHROMATOGRAPHIC SEPARATIONS; DRUG COMPOUNDS; IONIZATION CONSTANT; MELOXICAM; METHOD VALIDATIONS; MOBILE PHASE; MOBILE-PHASE COMPOSITION; NAPROXENS; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; OCTADECYLSILICA; PHARMACEUTICAL DOSAGE FORMS; PIROXICAM; RETENTION BEHAVIOR; RP-HPLC; SIMULTANEOUS DETERMINATIONS; TENOXICAM; UV DETECTION;

ACETONITRILE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIZATION OF LIQUIDS; PHOSPHORIC ACID;

DRUG DOSAGE;

ACETONITRILE; MELOXICAM; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHORIC ACID; PIROXICAM; TENOXICAM; WATER; DRUG; DRUG DERIVATIVE; THIAZINE DERIVATIVE; THIAZOLE DERIVATIVE;

ARTICLE; CHEMICAL PHENOMENA; CHEMICAL RETENTION; COLUMN CHROMATOGRAPHY; CONCENTRATION (PARAMETERS); DRUG DETERMINATION; DRUG DOSAGE FORM; DRUG STRUCTURE; ELUTION; IONIZATION; MOBILE PHASE; PH; PHASE SEPARATION; PKA; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; CHEMICAL STRUCTURE; CHEMISTRY; EVALUATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSTRUMENTATION; METHODOLOGY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MOLECULAR STRUCTURE; NAPROXEN; PHARMACEUTICAL PREPARATIONS; PIROXICAM; THIAZINES; THIAZOLES;

EID: 70450188437     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200900234     Document Type: Article

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