Efficacy and tolerability of eperisone in patients with spastic palsy: A cross-over, placebo-controlled dose-ranging trial

European Review for Medical and Pharmacological Sciences

Volumn 13, Issue 5, 2009, Pages 365-370

  Bresolin, Nereo ^a   Zucca, C ^b   Pecori, A ^c  

^a UNIVERSITY OF MILAN   (Italy)

^b SCIENTIFIC INSTITUTE   (Italy)

^c Medical Department Eisai Srl   (Italy)

Author keywords

Central muscle relaxants; Eperisone; Spastic palsy

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; EPERISONE; PLACEBO;

ABDOMINAL PAIN; ACHILLES REFLEX; ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANALGESIA; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD PRESSURE; BRAIN DISEASE; BURN; CLIMBING; CLINICAL ARTICLE; CLINICAL TRIAL; CLONUS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG TOLERABILITY; EXERCISE; FEMALE; FOOT; FOOT SOLE; FORMICATION; GASTROESOPHAGEAL REFLUX; HEART RATE; HEMIPARESIS; HUMAN; HYPERTENSION; INSOMNIA; LIMB FORMICATION; MALE; MULTIPLE CYCLE TREATMENT; PAIN ASSESSMENT; PARAPLEGIA; PATELLA; QUADRIPLEGIA; RANDOMIZED CONTROLLED TRIAL; REFLEX; REST; RIGIDITY; SIDE EFFECT; SPASTIC PARESIS; SPASTICITY; SPINE DISEASE; URTICARIA; WALKING; WEAKNESS;

ADULT; AGED; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; EXERCISE TEST; FEMALE; HUMANS; MALE; MIDDLE AGED; MUSCLE RELAXANTS, CENTRAL; MUSCLE RIGIDITY; MUSCLE SPASTICITY; PARALYSIS; PATELLAR LIGAMENT; PROPIOPHENONES; REFLEX; WALKING; YOUNG ADULT;

EID: 70450169261     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. DONES I. Intrathecal baclofen for the treatment of spasticity. Acta Neurochir Suppl 2007; 97 (Pt 1): 185-188.
2. TARIQ M, AKHTAR N, ALI M, RAO S, BADSHAH M, IRSHAD M. Eperisone compared to physiotherapy on muscular tone of stroke patients: a prospective randomized open study. J Pak Med Assoc 2005; 55: 202-204.
3. BIERING-SØRENSEN F, NIELSEN JB, KLINGE K. Spasticity-assessment: a review. Spinal Cord 2006; 44: 708-722.
4. BOSE K. The efficacy and safety of eperisone in patients with cervical spondylosis: results of a randomized, double-blind, placebo-controlled trial. Methods Find Exp Clin Pharmacol 1999; 21: 209-213.
5. CABITZA P, RANDELLI P. Efficacy and safety of eperisone in patients with low back pain: a double blind randomized study. Eur Rev Med Pharmacol Sci 2008; 12: 229-235.
6. BELTRAME A, GRANGIÈ S, GUERRA L. Clinical experience with eperisone in the treatment of acute low back pain. Minerva Med 2008; 99: 347-352.
7. SARTINI S, GUERRA L. Open experience with a new myorelaxant agent for low back pain. Adv Ther 2008; 25: 1010-1018.
8. TANAKA K, KANEKO T, YAMATSU K. Effects of 4′-ethyl-2-methyl-3- piperidinopropiophenone on experimental contracture and spinal cord activities. Folia Pharmacol Jpn 1981; 77: 511-520.
9. MANO T, MIYAOKA T. Effects of muscle relaxant E.M.P.P. on afferent discharges of muscle spindle in man -a microneurographic analysis. No To Shinkei 1981; 33: 237-241.
10. GRASSI C, PASSATORE M. Spontaneous sympathetic command to skeletal muscles; functional implications. Funct Neurol 1990; 5: 227-232.
11. IWASE S, MANO T, SAITO M, ISHIDA G. Effect of a centrally-acting muscle relaxant, eperisone hydrochloride, on muscle sympathetic nerve activity in humans. Funct Neurol 1992; 7: 459-470.
12. ISHIZUKI M, YANAGISAWA M. Antinociceptive effects of tizanidine, diazepam and eperisone in isolated spinal cord-tail preparations of newborn rat. Pain 1992; 48: 101-106.
13. SHAH J, WESNES KA, KOVELESKY RA, HENNEY HR 3RD. Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers. Clin Ther 2006; 28: 1308-1317.
14. BELTRAME A, GRANGIÈ S, GUERRA L. Clinical experience with eperisone in the treatment of acute low back pain. Minerva Med 2008; 99: 347-352.
15. YOSHIGORO. Clinical studies with E-0646 (Eperisone Hydrochloride). In: Spastic paralysis. Jap J Clin Experiment Med 1980; 57: 4033-4038.
16. WISSEL J. Multidisciplinary therapy for focal spasticity treatment. Nervenarzt 2008; 79 (Suppl. 1): 24-28.